DegronMD - Q2MJR0(SPRED3)

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D132Y	TCGA-34-5231	LUSC	TCGA	LTPSSS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.0833
p.D132Y	TCGA-34-5231	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1111
p.D132Y	DO26772	LUSC	ICGC	LTPSSS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.0833
p.D132Y	DO26772	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1111
p.A112T	TCGA-AA-3864	COAD	TCGA	LTPSSS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1667
p.A112T	TCGA-AA-3864	COAD	TCGA	PSSSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1111
p.A112T	TCGA-F4-6856	COAD	TCGA	LTPSSS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1667
p.A112T	TCGA-F4-6856	COAD	TCGA	PSSSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1111
p.A112T	DO9114	COAD	ICGC	LTPSSS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1667
p.A112T	DO9114	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1111
p.A112T	DO8490	COAD	ICGC	LTPSSS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1667
p.A112T	DO8490	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1111
p.P120S	TCGA-CD-A4MG	STAD	TCGA	LTPSSS	DEG_SCF_FBW7_1	118:123	Mutation altering degron motif	0.6752
p.P120S	TCGA-CD-A4MG	STAD	TCGA	PSSSS	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.6752
p.P120S	DO48009	STAD	ICGC	LTPSSS	DEG_SCF_FBW7_1	118:123	Mutation altering degron motif	0.6752
p.P120S	DO48009	STAD	ICGC	PSSSS	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.6752
p.A111D	TCGA-CN-5367	HNSC	TCGA	LTPSSS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1389
p.A111D	TCGA-CN-5367	HNSC	TCGA	PSSSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.0833
p.A111D	DO15894	HNSC	ICGC	LTPSSS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1389
p.A111D	DO15894	HNSC	ICGC	PSSSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.0833
p.A108V	TCGA-E5-A4TZ	BLCA	TCGA	LTPSSS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.0556
p.A108V	DO44055	BLCA	ICGC	LTPSSS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.0556
p.R218H	TCGA-FD-A5BZ	BLCA	TCGA	DYR	CBL_MET	222:224	Mutation rewiring degron network	0.2222
p.R218H	DO44052	BLCA	ICGC	DYR	CBL_MET	222:224	Mutation rewiring degron network	0.2222
p.R218H	DO50401	ESAD	ICGC	DYR	CBL_MET	222:224	Mutation rewiring degron network	0.2222
p.S121F	TCGA-G2-A2EO	BLCA	TCGA	LTPSSS	DEG_SCF_FBW7_1	118:123	Mutation altering degron motif	0.6871
p.S121F	TCGA-G2-A2EO	BLCA	TCGA	PSSSS	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.6871
p.S121F	DO456	BLCA	ICGC	LTPSSS	DEG_SCF_FBW7_1	118:123	Mutation altering degron motif	0.6871
p.S121F	DO456	BLCA	ICGC	PSSSS	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.6871
p.A233T	TCGA-HU-A4GQ	STAD	TCGA	DYR	CBL_MET	222:224	Mutation rewiring degron network	0.0833
p.A233T	DO47767	STAD	ICGC	DYR	CBL_MET	222:224	Mutation rewiring degron network	0.0833
p.A233T	ACH-000856	Breast Cancer	CCLE	DYR	CBL_MET	222:224	Mutation rewiring degron network	0.0833
p.G214W	TCGA-NJ-A4YI	LUAD	TCGA	DYR	CBL_MET	222:224	Mutation rewiring degron network	0.1111
p.G214W	DO218942	LUAD	ICGC	DYR	CBL_MET	222:224	Mutation rewiring degron network	0.1111
p.A109V	DO230312	COCA	ICGC	LTPSSS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.0833
p.R225H	DO233624	GACA	ICGC	DYR	CBL_MET	222:224	Mutation rewiring degron network	0.3056
p.R115Q	DO220899	MELA	ICGC	LTPSSS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.25
p.R115Q	DO220899	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1944
p.D132G	DO47911	STAD	ICGC	LTPSSS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.0833
p.D132G	DO47911	STAD	ICGC	PSSSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1111
p.Q131K	DO229221	THCA	ICGC	LTPSSS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.1111
p.Q131K	DO229221	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1389
p.L232P	SIDM02072	Colorectal Carcinoma	GDSC	DYR	CBL_MET	222:224	Mutation rewiring degron network	0.1111
p.G214A	SIDM02021	Esophageal Carcinoma	GDSC	DYR	CBL_MET	222:224	Mutation rewiring degron network	0.1111
p.L234V	SIDM00007	Other Solid Cancers	GDSC	DYR	CBL_MET	222:224	Mutation rewiring degron network	0.0556
p.L234V	SIDM00854	Burkitt's Lymphoma	GDSC	DYR	CBL_MET	222:224	Mutation rewiring degron network	0.0556
p.G212D	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	222:224	Mutation rewiring degron network	0.0556
p.Y223H	SIDM00364	B-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	222:224	Mutation altering degron motif	0.834
p.Y223H	ACH-002059	Leukemia	CCLE	DYR	CBL_MET	222:224	Mutation altering degron motif	0.834
p.D132N	SIDM00534	Colorectal Carcinoma	GDSC	LTPSSS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.0833
p.D132N	SIDM00534	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1111
p.D132N	ACH-000986	Colon/Colorectal Cancer	CCLE	LTPSSS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.0833
p.D132N	ACH-000986	Colon/Colorectal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1111
p.D132N	HT-115	large intestine	COSMIC	LTPSSS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.0833
p.D132N	HT-115	large intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1111
p.G227A	ACH-001131	Skin Cancer	CCLE	DYR	CBL_MET	222:224	Mutation rewiring degron network	0.25
p.V119M	CW-2	large intestine	COSMIC	LTPSSS	DEG_SCF_FBW7_1	118:123	Mutation altering degron motif	0.7208
p.V115I	MZ7-mel	skin	COSMIC	LTPSSS	DEG_SCF_FBW7_1	118:123	Mutation rewiring degron network	0.25
p.V115I	MZ7-mel	skin	COSMIC	PSSSS	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPRED3

UniProt ID: Q2MJR0

Entrez ID: 399473

Protein name: Sprouty-related, EVH1 domain-containing protein 3 (Spred-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPRED3 in