DegronMD

Uniprot ID: Q2MJR0

Source protein: Sprouty-related, EVH1 domain-containing protein 3

Source gene: SPRED3

Class: DEG_SCF_FBW7_1

Location: 118:123

E3 ligase: FBXW7

DEGRON score: 0.9855

ASA_SCORE: 68.1833

COIL: 0.8712

CONS_SCORE: 0.5777

DSS_SCORE: 0.5694

HELIX: 0.0818

FCONS_SCORE: 1.0393

RIG_SCORE: 0.5241

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D132Y	TCGA-34-5231	LUSC	TCGA	LTPSSS	DEG_SCF_FBW7_1	0.0833
p.D132Y	DO26772	LUSC	ICGC	LTPSSS	DEG_SCF_FBW7_1	0.0833
p.A112T	TCGA-AA-3864	COAD	TCGA	LTPSSS	DEG_SCF_FBW7_1	0.1667
p.A112T	TCGA-F4-6856	COAD	TCGA	LTPSSS	DEG_SCF_FBW7_1	0.1667
p.A112T	DO9114	COAD	ICGC	LTPSSS	DEG_SCF_FBW7_1	0.1667
p.A112T	DO8490	COAD	ICGC	LTPSSS	DEG_SCF_FBW7_1	0.1667
p.P120S	TCGA-CD-A4MG	STAD	TCGA	LTPSSS	DEG_SCF_FBW7_1	0.6752
p.P120S	DO48009	STAD	ICGC	LTPSSS	DEG_SCF_FBW7_1	0.6752
p.A111D	TCGA-CN-5367	HNSC	TCGA	LTPSSS	DEG_SCF_FBW7_1	0.1389
p.A111D	DO15894	HNSC	ICGC	LTPSSS	DEG_SCF_FBW7_1	0.1389
p.A108V	TCGA-E5-A4TZ	BLCA	TCGA	LTPSSS	DEG_SCF_FBW7_1	0.0556
p.A108V	DO44055	BLCA	ICGC	LTPSSS	DEG_SCF_FBW7_1	0.0556
p.S121F	TCGA-G2-A2EO	BLCA	TCGA	LTPSSS	DEG_SCF_FBW7_1	0.6871
p.S121F	DO456	BLCA	ICGC	LTPSSS	DEG_SCF_FBW7_1	0.6871
p.A109V	DO230312	COCA	ICGC	LTPSSS	DEG_SCF_FBW7_1	0.0833
p.R115Q	DO220899	MELA	ICGC	LTPSSS	DEG_SCF_FBW7_1	0.25
p.D132G	DO47911	STAD	ICGC	LTPSSS	DEG_SCF_FBW7_1	0.0833
p.Q131K	DO229221	THCA	ICGC	LTPSSS	DEG_SCF_FBW7_1	0.1111
p.D132N	SIDM00534	Colorectal Carcinoma	GDSC	LTPSSS	DEG_SCF_FBW7_1	0.0833
p.D132N	ACH-000986	Colon/Colorectal Cancer	CCLE	LTPSSS	DEG_SCF_FBW7_1	0.0833
p.D132N	HT-115	large_intestine	COSMIC	LTPSSS	DEG_SCF_FBW7_1	0.0833
p.V119M	CW-2	large_intestine	COSMIC	LTPSSS	DEG_SCF_FBW7_1	0.7208
p.V115I	MZ7-mel	skin	COSMIC	LTPSSS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2MJR0	Sprouty-related, EVH1 domain-containing protein 3	DEG_SCF_FBW7_1	118:123	LTPSSS	FBXW7	0.9855	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons