DegronMD

Uniprot ID: Q9H6Y2

Source protein: WD repeat-containing protein 55

Source gene: WDR55

Class: CBL_MET

Location: 334:336

E3 ligase: CBL

DEGRON score: 0.7633

ASA_SCORE: 106.5

COIL: 0.6987

CONS_SCORE: 0.443

DSS_SCORE: 0.3245

HELIX: 0.1877

FCONS_SCORE: 1.0701

RIG_SCORE: 0.8917

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R336C	DO228584	MALY	ICGC	DYR	CBL_MET	0.8301
p.D333A	TCGA-CW-6093	KIRC	TCGA	DYR	CBL_MET	0.3056
p.D333A	DO16248	KIRC	ICGC	DYR	CBL_MET	0.3056
p.R337W	TCGA-DC-6160	READ	TCGA	DYR	CBL_MET	0.3056
p.R337W	TCGA-DF-A2KU	UCEC	TCGA	DYR	CBL_MET	0.3056
p.R337W	DO36391	READ	ICGC	DYR	CBL_MET	0.3056
p.R337W	DO223286	UCEC	ICGC	DYR	CBL_MET	0.3056
p.K341R	DO234230	ESAD	ICGC	DYR	CBL_MET	0.3056
p.K341R	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	DYR	CBL_MET	0.3056
p.K341R	ACH-002046	Endometrial/Uterine Cancer	CCLE	DYR	CBL_MET	0.3056
p.R338H	TCGA-DI-A0WH	UCEC	TCGA	DYR	CBL_MET	0.2778
p.R338H	TCGA-DU-6392	LGG	TCGA	DYR	CBL_MET	0.2778
p.R338H	TCGA-WQ-A9G7	LIHC	TCGA	DYR	CBL_MET	0.2778
p.R338H	DO22237	LGG	ICGC	DYR	CBL_MET	0.2778
p.R338H	DO52326	LIHC	ICGC	DYR	CBL_MET	0.2778
p.R338H	DO43843	UCEC	ICGC	DYR	CBL_MET	0.2778
p.A325T	TCGA-CK-5916	COAD	TCGA	DYR	CBL_MET	0.0833
p.A325T	DO8786	COAD	ICGC	DYR	CBL_MET	0.0833
p.M324I	DO218874	SKCA	ICGC	DYR	CBL_MET	0.0556
p.R346Q	SIDM01770	Gastric Carcinoma	GDSC	DYR	CBL_MET	0.0556
p.R346Q	ACH-000908	Gastric Cancer	CCLE	DYR	CBL_MET	0.0556

Showing 1 to 21 of 21 entries

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Drug responses associated with WDR55 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of DYR

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2I7	1-phosphatidylinositol 3-phosphate 5-kinase	CBL_MET	1154:1156	DYR	CBL	0.9899	More...
P62333	26S proteasome regulatory subunit 10B	CBL_MET	11:13	DYR	CBL	0.5589	More...
Q96A35	39S ribosomal protein L24, mitochondrial	CBL_MET	103:105	DYR	CBL	0.8186	More...
Q9P2N4	A disintegrin and metalloproteinase with thrombospondin motifs 9	CBL_MET	1313:1315	DYR	CBL	0.9337	More...
Q12802	A-kinase anchor protein 13	CBL_MET	823:825	DYR	CBL	0.8159	More...
Q96K21	Abscission/NoCut checkpoint regulator	CBL_MET	348:350	DYR	CBL	0.5257	More...
P40145	Adenylate cyclase type 8	CBL_MET	1148:1150	DYR	CBL	0.7268	More...
P51825	AF4/FMR2 family member 1	CBL_MET	316:318	DYR	CBL	0.9069	More...
Q9P0K7	Ankycorbin	CBL_MET	661:663	DYR	CBL	0.6245	More...
Q6UB99	Ankyrin repeat domain-containing protein 11	CBL_MET	864:866	DYR	CBL	0.5334	More...
Q6UB99	Ankyrin repeat domain-containing protein 11	CBL_MET	899:901	DYR	CBL	0.7809	More...
Q96NW4	Ankyrin repeat domain-containing protein 27	CBL_MET	666:668	DYR	CBL	0.9069	More...
Q8N944	APC membrane recruitment protein 3	CBL_MET	128:130	DYR	CBL	0.9544	More...
Q9BZC7	ATP-binding cassette sub-family A member 2	CBL_MET	1395:1397	DYR	CBL	0.9909	More...
Q08211	ATP-dependent RNA helicase A	CBL_MET	1233:1235	DYR	CBL	0.9757	More...
O00571	ATP-dependent RNA helicase DDX3X	CBL_MET	601:603	DYR	CBL	0.9982	More...
O15523	ATP-dependent RNA helicase DDX3Y	CBL_MET	599:601	DYR	CBL	0.9998	More...
Q9NYF8	Bcl-2-associated transcription factor 1	CBL_MET	56:58	DYR	CBL	0.7315	More...
Q9NYF8	Bcl-2-associated transcription factor 1	CBL_MET	60:62	DYR	CBL	0.9219	More...
Q9NYF8	Bcl-2-associated transcription factor 1	CBL_MET	407:409	DYR	CBL	0.8675	More...
A2AJT9	BCLAF1 and THRAP3 family member 3	CBL_MET	280:282	DYR	CBL	0.8797	More...
Q9NWK9	Box C/D snoRNA protein 1	CBL_MET	277:279	DYR	CBL	0.8233	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	CBL_MET	563:565	DYR	CBL	0.9622	More...
P25440	Bromodomain-containing protein 2	CBL_MET	407:409	DYR	CBL	0.9586	More...
Q2TAL6	Brorin	CBL_MET	149:151	DYR	CBL	0.987	More...

Showing 1 to 25 of 231 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DYR

Degron related mutations and impact score

Drug responses associated with WDR55 mutations

All proteins holding degron of DYR