DegronMD - Q9HCL0(PCDH18)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G951R	TCGA-06-0184	GBM	TCGA	DYR	CBL_MET	942:944	Mutation rewiring degron network	0.1389
p.D884E	TCGA-2H-A9GF	ESCA	TCGA	DSGRGDS	DEG_SCF_TRCP1_1	872:878	Mutation rewiring degron network	0.1667
p.L862F	TCGA-33-AASB	LUSC	TCGA	YRYALQDMD	DEG_APCC_DBOX_1	858:866	Mutation altering degron motif	0.6981
p.W932R	TCGA-55-1595	LUAD	TCGA	DYR	CBL_MET	942:944	Mutation rewiring degron network	0.0556
p.A861S	TCGA-62-A46O	LUAD	TCGA	YRYALQDMD	DEG_APCC_DBOX_1	858:866	Mutation altering degron motif	0.6477
p.S857G	TCGA-AG-3906	READ	TCGA	YRYALQDMD	DEG_APCC_DBOX_1	858:866	Mutation rewiring degron network	0.3056
p.P939L	TCGA-AG-4009	READ	TCGA	DYR	CBL_MET	942:944	Mutation rewiring degron network	0.25
p.S848R	TCGA-AH-6903	READ	TCGA	YRYALQDMD	DEG_APCC_DBOX_1	858:866	Mutation rewiring degron network	0.0556
p.Q863R	TCGA-AX-A3FS	UCEC	TCGA	YRYALQDMD	DEG_APCC_DBOX_1	858:866	Mutation altering degron motif	0.6218
p.D882Y	TCGA-B5-A1MR	UCEC	TCGA	DSGRGDS	DEG_SCF_TRCP1_1	872:878	Mutation rewiring degron network	0.2222
p.S945N	TCGA-B5-A3FC	UCEC	TCGA	DYR	CBL_MET	942:944	Mutation rewiring degron network	0.3056
p.E879K	TCGA-D3-A8GI	SKCM	TCGA	DSGRGDS	DEG_SCF_TRCP1_1	872:878	Mutation rewiring degron network	0.3056
p.P950S	TCGA-EE-A2A1	SKCM	TCGA	DYR	CBL_MET	942:944	Mutation rewiring degron network	0.1667
p.S855F	TCGA-EE-A3AA	SKCM	TCGA	YRYALQDMD	DEG_APCC_DBOX_1	858:866	Mutation rewiring degron network	0.25
p.D886N	TCGA-EE-A3JB	SKCM	TCGA	DSGRGDS	DEG_SCF_TRCP1_1	872:878	Mutation rewiring degron network	0.1111
p.D886N	TCGA-EE-A3JD	SKCM	TCGA	DSGRGDS	DEG_SCF_TRCP1_1	872:878	Mutation rewiring degron network	0.1111
p.E952K	TCGA-FS-A1ZK	SKCM	TCGA	DYR	CBL_MET	942:944	Mutation rewiring degron network	0.1111
p.D877V	TCGA-HC-7233	PRAD	TCGA	DSGRGDS	DEG_SCF_TRCP1_1	872:878	Mutation altering degron motif	0.6674
p.S848G	TCGA-HU-A4H6	STAD	TCGA	YRYALQDMD	DEG_APCC_DBOX_1	858:866	Mutation rewiring degron network	0.0556
p.L887F	TCGA-W3-A824	SKCM	TCGA	DSGRGDS	DEG_SCF_TRCP1_1	872:878	Mutation rewiring degron network	0.0833
p.R850Q	TCGA-W3-AA1O	SKCM	TCGA	YRYALQDMD	DEG_APCC_DBOX_1	858:866	Mutation rewiring degron network	0.1111
p.R943S	DO48418	BLCA	ICGC	DYR	CBL_MET	942:944	Mutation altering degron motif	0.7427
p.G875A	DO51975	CLLE	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	872:878	Mutation altering degron motif	0.754
p.R888Q	DO7810	COAD	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	872:878	Mutation rewiring degron network	0.0556
p.R888Q	DO37839	SKCM	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	872:878	Mutation rewiring degron network	0.0556
p.R888Q	DO50287	SKCM	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	872:878	Mutation rewiring degron network	0.0556
p.R888Q	DO48665	SKCM	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	872:878	Mutation rewiring degron network	0.0556
p.K870T	DO222762	COCA	ICGC	YRYALQDMD	DEG_APCC_DBOX_1	858:866	Mutation rewiring degron network	0.2222
p.K870T	DO222762	COCA	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	872:878	Mutation rewiring degron network	0.2778
p.L886F	DO234270	ESAD	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	872:878	Mutation rewiring degron network	0.1111
p.L886F	DO51271	SKCM	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	872:878	Mutation rewiring degron network	0.1111
p.Y853F	DO233271	GACA	ICGC	YRYALQDMD	DEG_APCC_DBOX_1	858:866	Mutation substituting flanking lysine	0.3056
p.P938L	DO233772	GACA	ICGC	DYR	CBL_MET	942:944	Mutation blocking phosphorylation signal	0.6667
p.P938L	DO36961	READ	ICGC	DYR	CBL_MET	942:944	Mutation blocking phosphorylation signal	0.6667
p.P949R	DO233905	GACA	ICGC	DYR	CBL_MET	942:944	Mutation rewiring degron network	0.1944
p.G950R	DO12496	GBM	ICGC	DYR	CBL_MET	942:944	Mutation rewiring degron network	0.1667
p.D865E	DO228974	LICA	ICGC	YRYALQDMD	DEG_APCC_DBOX_1	858:866	Mutation altering degron motif	0.6758
p.A879E	DO229027	LICA	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	872:878	Mutation rewiring degron network	0.3056
p.D883Y	DO231646	LINC	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	872:878	Mutation rewiring degron network	0.1944
p.R849Q	DO45045	LINC	ICGC	YRYALQDMD	DEG_APCC_DBOX_1	858:866	Mutation rewiring degron network	0.0833
p.R849Q	DO51274	SKCM	ICGC	YRYALQDMD	DEG_APCC_DBOX_1	858:866	Mutation rewiring degron network	0.0833
p.P954T	DO26220	LUAD	ICGC	DYR	CBL_MET	942:944	Mutation rewiring degron network	0.0556
p.A860S	DO26240	LUAD	ICGC	YRYALQDMD	DEG_APCC_DBOX_1	858:866	Mutation altering degron motif	0.7588
p.L861F	DO219125	LUSC	ICGC	YRYALQDMD	DEG_APCC_DBOX_1	858:866	Mutation altering degron motif	0.6981
p.S854F	DO222632	MELA	ICGC	YRYALQDMD	DEG_APCC_DBOX_1	858:866	Mutation rewiring degron network	0.2222
p.S854F	DO37571	SKCM	ICGC	YRYALQDMD	DEG_APCC_DBOX_1	858:866	Mutation rewiring degron network	0.2222
p.D885N	DO222644	MELA	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	872:878	Mutation blocking phosphorylation signal	0.5833
p.D885N	DO218840	SKCA	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	872:878	Mutation blocking phosphorylation signal	0.5833
p.D885N	DO50299	SKCM	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	872:878	Mutation blocking phosphorylation signal	0.5833
p.D885N	DO51250	SKCM	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	872:878	Mutation blocking phosphorylation signal	0.5833
p.G950E	DO222875	MELA	ICGC	DYR	CBL_MET	942:944	Mutation rewiring degron network	0.1667
p.R874C	DO51498	PACA	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	872:878	Mutation altering degron motif	0.8301
p.N945T	DO232761	PBCA	ICGC	DYR	CBL_MET	942:944	Mutation rewiring degron network	0.3056
p.D876V	DO46813	PRAD	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	872:878	Mutation altering degron motif	0.7785
p.S856G	DO36491	READ	ICGC	YRYALQDMD	DEG_APCC_DBOX_1	858:866	Mutation rewiring degron network	0.2778
p.R943K	DO218855	SKCA	ICGC	DYR	CBL_MET	942:944	Mutation altering degron motif	0.7237
p.E951K	DO37474	SKCM	ICGC	DYR	CBL_MET	942:944	Mutation rewiring degron network	0.1389
p.E878K	DO50284	SKCM	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	872:878	Mutation altering degron motif	0.7022
p.P949S	DO38045	SKCM	ICGC	DYR	CBL_MET	942:944	Mutation rewiring degron network	0.1944
p.Q862R	DO40879	UCEC	ICGC	YRYALQDMD	DEG_APCC_DBOX_1	858:866	Mutation altering degron motif	0.7329
p.D881Y	DO41758	UCEC	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	872:878	Mutation rewiring degron network	0.25
p.S944N	DO41871	UCEC	ICGC	DYR	CBL_MET	942:944	Mutation altering degron motif	0.7069
p.R875H	SIDM01278	Colorectal Carcinoma	GDSC	DSGRGDS	DEG_SCF_TRCP1_1	872:878	Mutation altering degron motif	0.7133
p.G951W	SIDM00120	Prostate Carcinoma	GDSC	DYR	CBL_MET	942:944	Mutation rewiring degron network	0.1389
p.G951W	DU-145	prostate	COSMIC	DYR	CBL_MET	942:944	Mutation rewiring degron network	0.1389
p.S856P	ACH-000303	Gastric Cancer	CCLE	YRYALQDMD	DEG_APCC_DBOX_1	858:866	Mutation rewiring degron network	0.2778
p.S856P	NCI-SNU-5	stomach	COSMIC	YRYALQDMD	DEG_APCC_DBOX_1	858:866	Mutation rewiring degron network	0.2778
p.E876K	ACH-000548	Head and Neck Cancer	CCLE	DSGRGDS	DEG_SCF_TRCP1_1	872:878	Mutation altering degron motif	0.7022
p.E876K	BHY	upper aerodigestive tract	COSMIC	DSGRGDS	DEG_SCF_TRCP1_1	872:878	Mutation altering degron motif	0.7022
p.M868I	ACH-000955	Colon/Colorectal Cancer	CCLE	YRYALQDMD	DEG_APCC_DBOX_1	858:866	Mutation rewiring degron network	0.2778
p.M868I	ACH-000955	Colon/Colorectal Cancer	CCLE	DSGRGDS	DEG_SCF_TRCP1_1	872:878	Mutation rewiring degron network	0.2222
p.M868I	SNU-407	large intestine	COSMIC	YRYALQDMD	DEG_APCC_DBOX_1	858:866	Mutation rewiring degron network	0.2778
p.M868I	SNU-407	large intestine	COSMIC	DSGRGDS	DEG_SCF_TRCP1_1	872:878	Mutation rewiring degron network	0.2222
p.V883L	ACH-001233	Lung Cancer	CCLE	DSGRGDS	DEG_SCF_TRCP1_1	872:878	Mutation rewiring degron network	0.1944
p.V883L	VMRC-LCD	lung	COSMIC	DSGRGDS	DEG_SCF_TRCP1_1	872:878	Mutation rewiring degron network	0.1944
p.S856F	ACH-001973	Metastasis	CCLE	YRYALQDMD	DEG_APCC_DBOX_1	858:866	Mutation rewiring degron network	0.2778
p.G950W	DU-145	prostate	COSMIC	DYR	CBL_MET	942:944	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCDH18

UniProt ID: Q9HCL0

Entrez ID: 54510

Protein name: Protocadherin-18

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PCDH18 in