DegronMD

Uniprot ID: Q9HCL0

Source protein: Protocadherin-18

Source gene: PCDH18

Class: DEG_APCC_DBOX_1

Location: 858:866

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6463

ASA_SCORE: 66.3444

COIL: 0.5708

CONS_SCORE: 0.5153

DSS_SCORE: 0.3931

HELIX: 0.2618

FCONS_SCORE: 1.0107

RIG_SCORE: 0.799

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L862F	TCGA-33-AASB	LUSC	TCGA	YRYALQDMD	DEG_APCC_DBOX_1	0.6981
p.A861S	TCGA-62-A46O	LUAD	TCGA	YRYALQDMD	DEG_APCC_DBOX_1	0.6477
p.S857G	TCGA-AG-3906	READ	TCGA	YRYALQDMD	DEG_APCC_DBOX_1	0.3056
p.S848R	TCGA-AH-6903	READ	TCGA	YRYALQDMD	DEG_APCC_DBOX_1	0.0556
p.Q863R	TCGA-AX-A3FS	UCEC	TCGA	YRYALQDMD	DEG_APCC_DBOX_1	0.6218
p.S855F	TCGA-EE-A3AA	SKCM	TCGA	YRYALQDMD	DEG_APCC_DBOX_1	0.25
p.S848G	TCGA-HU-A4H6	STAD	TCGA	YRYALQDMD	DEG_APCC_DBOX_1	0.0556
p.R850Q	TCGA-W3-AA1O	SKCM	TCGA	YRYALQDMD	DEG_APCC_DBOX_1	0.1111
p.K870T	DO222762	COCA	ICGC	YRYALQDMD	DEG_APCC_DBOX_1	0.2222
p.Y853F	DO233271	GACA	ICGC	YRYALQDMD	DEG_APCC_DBOX_1	0.3056
p.D865E	DO228974	LICA	ICGC	YRYALQDMD	DEG_APCC_DBOX_1	0.6758
p.R849Q	DO45045	LINC	ICGC	YRYALQDMD	DEG_APCC_DBOX_1	0.0833
p.R849Q	DO51274	SKCM	ICGC	YRYALQDMD	DEG_APCC_DBOX_1	0.0833
p.A860S	DO26240	LUAD	ICGC	YRYALQDMD	DEG_APCC_DBOX_1	0.7588
p.L861F	DO219125	LUSC	ICGC	YRYALQDMD	DEG_APCC_DBOX_1	0.6981
p.S854F	DO222632	MELA	ICGC	YRYALQDMD	DEG_APCC_DBOX_1	0.2222
p.S854F	DO37571	SKCM	ICGC	YRYALQDMD	DEG_APCC_DBOX_1	0.2222
p.S856G	DO36491	READ	ICGC	YRYALQDMD	DEG_APCC_DBOX_1	0.2778
p.Q862R	DO40879	UCEC	ICGC	YRYALQDMD	DEG_APCC_DBOX_1	0.7329
p.S856P	ACH-000303	Gastric Cancer	CCLE	YRYALQDMD	DEG_APCC_DBOX_1	0.2778
p.S856P	NCI-SNU-5	stomach	COSMIC	YRYALQDMD	DEG_APCC_DBOX_1	0.2778
p.M868I	ACH-000955	Colon/Colorectal Cancer	CCLE	YRYALQDMD	DEG_APCC_DBOX_1	0.2778
p.M868I	SNU-407	large_intestine	COSMIC	YRYALQDMD	DEG_APCC_DBOX_1	0.2778
p.S856F	ACH-001973	Metastasis	CCLE	YRYALQDMD	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCL0	Protocadherin-18	DEG_APCC_DBOX_1	858:866	YRYALQDMD	APC,CDC20,FZR1	0.6463	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons