DegronMD

Uniprot ID: Q9HCL0

Source protein: Protocadherin-18

Source gene: PCDH18

Class: DEG_SCF_TRCP1_1

Location: 872:878

E3 ligase: BTRC

DEGRON score: 0.995

ASA_SCORE: 63.9857

COIL: 0.7914

CONS_SCORE: 0.5818

DSS_SCORE: 0.5354

HELIX: 0.147

FCONS_SCORE: 1.1321

RIG_SCORE: 0.6052

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D884E	TCGA-2H-A9GF	ESCA	TCGA	DSGRGDS	DEG_SCF_TRCP1_1	0.1667
p.D882Y	TCGA-B5-A1MR	UCEC	TCGA	DSGRGDS	DEG_SCF_TRCP1_1	0.2222
p.E879K	TCGA-D3-A8GI	SKCM	TCGA	DSGRGDS	DEG_SCF_TRCP1_1	0.3056
p.D886N	TCGA-EE-A3JB	SKCM	TCGA	DSGRGDS	DEG_SCF_TRCP1_1	0.1111
p.D886N	TCGA-EE-A3JD	SKCM	TCGA	DSGRGDS	DEG_SCF_TRCP1_1	0.1111
p.D877V	TCGA-HC-7233	PRAD	TCGA	DSGRGDS	DEG_SCF_TRCP1_1	0.6674
p.L887F	TCGA-W3-A824	SKCM	TCGA	DSGRGDS	DEG_SCF_TRCP1_1	0.0833
p.G875A	DO51975	CLLE	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	0.754
p.R888Q	DO7810	COAD	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	0.0556
p.R888Q	DO37839	SKCM	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	0.0556
p.R888Q	DO50287	SKCM	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	0.0556
p.R888Q	DO48665	SKCM	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	0.0556
p.K870T	DO222762	COCA	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	0.2778
p.L886F	DO234270	ESAD	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	0.1111
p.L886F	DO51271	SKCM	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	0.1111
p.A879E	DO229027	LICA	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	0.3056
p.D883Y	DO231646	LINC	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	0.1944
p.D885N	DO222644	MELA	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	0.5833
p.D885N	DO218840	SKCA	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	0.5833
p.D885N	DO50299	SKCM	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	0.5833
p.D885N	DO51250	SKCM	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	0.5833
p.R874C	DO51498	PACA	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	0.8301
p.D876V	DO46813	PRAD	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	0.7785
p.E878K	DO50284	SKCM	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	0.7022
p.D881Y	DO41758	UCEC	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	0.25
p.R875H	SIDM01278	Colorectal Carcinoma	GDSC	DSGRGDS	DEG_SCF_TRCP1_1	0.7133
p.E876K	ACH-000548	Head and Neck Cancer	CCLE	DSGRGDS	DEG_SCF_TRCP1_1	0.7022
p.E876K	BHY	upper_aerodigestive_tract	COSMIC	DSGRGDS	DEG_SCF_TRCP1_1	0.7022
p.M868I	ACH-000955	Colon/Colorectal Cancer	CCLE	DSGRGDS	DEG_SCF_TRCP1_1	0.2222
p.M868I	SNU-407	large_intestine	COSMIC	DSGRGDS	DEG_SCF_TRCP1_1	0.2222
p.V883L	ACH-001233	Lung Cancer	CCLE	DSGRGDS	DEG_SCF_TRCP1_1	0.1944
p.V883L	VMRC-LCD	lung	COSMIC	DSGRGDS	DEG_SCF_TRCP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53EL6	Programmed cell death protein 4	DEG_SCF_TRCP1_1	70:76	DSGRGDS	BTRC	0.9941	More...
Q9HCL0	Protocadherin-18	DEG_SCF_TRCP1_1	872:878	DSGRGDS	BTRC	0.995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGRGDS

Degron related mutations and impact score

Drug responses associated with PCDH18 mutations

All proteins holding degron of DSGRGDS