DegronMD

Uniprot ID: Q53EL6

Source protein: Programmed cell death protein 4

Source gene: PDCD4

Class: DEG_SCF_TRCP1_1

Location: 70:76

E3 ligase: BTRC

DEGRON score: 0.9941

ASA_SCORE: 87.7429

COIL: 0.9331

CONS_SCORE: 0.3645

DSS_SCORE: 0.636

HELIX: 0.0433

FCONS_SCORE: 1.1142

RIG_SCORE: 0.5282

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D79Y	TCGA-17-Z022	LUAD	TCGA	DSGRGDS	DEG_SCF_TRCP1_1	0.25
p.K65T	TCGA-A5-A2K5	UCEC	TCGA	DSGRGDS	DEG_SCF_TRCP1_1	0.3056
p.K65T	DO41379	UCEC	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	0.3056
p.R69Q	TCGA-AP-A059	UCEC	TCGA	DSGRGDS	DEG_SCF_TRCP1_1	0.3056
p.R69Q	DO41361	UCEC	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	0.3056
p.S67L	TCGA-FD-A5C1	BLCA	TCGA	DSGRGDS	DEG_SCF_TRCP1_1	0.6944
p.S67L	DO44043	BLCA	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	0.6944
p.A84T	TCGA-MA-AA42	CESC	TCGA	DSGRGDS	DEG_SCF_TRCP1_1	0.1111
p.A84T	TCGA-VS-A94Z	CESC	TCGA	DSGRGDS	DEG_SCF_TRCP1_1	0.1111
p.A84T	DO219724	CESC	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	0.1111
p.A84T	DO51634	CESC	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	0.1111
p.A84T	DO230343	COCA	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	0.1111
p.A84T	DO233709	GACA	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	0.1111
p.A84S	TCGA-ZS-A9CE	LIHC	TCGA	DSGRGDS	DEG_SCF_TRCP1_1	0.1111
p.A84S	DO49720	LIHC	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	0.1111
p.S82I	DO6351	CLLE	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	0.6111
p.S76L	DO233628	GACA	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	0.8778
p.R69L	DO228948	LICA	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	0.3056
p.G72V	DO228948	LICA	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	0.7532
p.G72V	DO229029	LICA	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	0.7532
p.S80I	SIDM00443	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGRGDS	DEG_SCF_TRCP1_1	0.6667
p.S80I	ACH-000287	Lymphoma	CCLE	DSGRGDS	DEG_SCF_TRCP1_1	0.6667
p.S80I	NU-DUL-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGRGDS	DEG_SCF_TRCP1_1	0.6667
p.R69W	SIDM00451	T-Lymphoblastic Leukemia	GDSC	DSGRGDS	DEG_SCF_TRCP1_1	0.3056
p.R69W	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	DSGRGDS	DEG_SCF_TRCP1_1	0.3056
p.S69I	NU-DUL-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGRGDS	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53EL6	Programmed cell death protein 4	DEG_SCF_TRCP1_1	70:76	DSGRGDS	BTRC	0.9941	More...
Q9HCL0	Protocadherin-18	DEG_SCF_TRCP1_1	872:878	DSGRGDS	BTRC	0.995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGRGDS

Degron related mutations and impact score

Drug responses associated with PDCD4 mutations

All proteins holding degron of DSGRGDS