DegronMD - Q53EL6(PDCD4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D79Y	TCGA-17-Z022	LUAD	TCGA	DSGRGDS	DEG_SCF_TRCP1_1	70:76	Mutation rewiring degron network	0.25
p.K65T	TCGA-A5-A2K5	UCEC	TCGA	DSGRGDS	DEG_SCF_TRCP1_1	70:76	Mutation substituting flanking lysine	0.3056
p.K65T	DO41379	UCEC	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	70:76	Mutation substituting flanking lysine	0.3056
p.R69Q	TCGA-AP-A059	UCEC	TCGA	DSGRGDS	DEG_SCF_TRCP1_1	70:76	Mutation rewiring degron network	0.3056
p.R69Q	DO41361	UCEC	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	70:76	Mutation rewiring degron network	0.3056
p.S67L	TCGA-FD-A5C1	BLCA	TCGA	DSGRGDS	DEG_SCF_TRCP1_1	70:76	Mutation blocking phosphorylation signal	0.6944
p.S67L	DO44043	BLCA	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	70:76	Mutation blocking phosphorylation signal	0.6944
p.A84T	TCGA-MA-AA42	CESC	TCGA	DSGRGDS	DEG_SCF_TRCP1_1	70:76	Mutation rewiring degron network	0.1111
p.A84T	TCGA-VS-A94Z	CESC	TCGA	DSGRGDS	DEG_SCF_TRCP1_1	70:76	Mutation rewiring degron network	0.1111
p.A84T	DO219724	CESC	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	70:76	Mutation rewiring degron network	0.1111
p.A84T	DO51634	CESC	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	70:76	Mutation rewiring degron network	0.1111
p.A84T	DO230343	COCA	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	70:76	Mutation rewiring degron network	0.1111
p.A84T	DO233709	GACA	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	70:76	Mutation rewiring degron network	0.1111
p.A84S	TCGA-ZS-A9CE	LIHC	TCGA	DSGRGDS	DEG_SCF_TRCP1_1	70:76	Mutation rewiring degron network	0.1111
p.A84S	DO49720	LIHC	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	70:76	Mutation rewiring degron network	0.1111
p.S82I	DO6351	CLLE	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	70:76	Mutation blocking phosphorylation signal	0.6111
p.S76L	DO233628	GACA	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	70:76	Mutation altering degron motif	0.8778
p.R69L	DO228948	LICA	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	70:76	Mutation rewiring degron network	0.3056
p.G72V	DO228948	LICA	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	70:76	Mutation altering degron motif	0.7532
p.G72V	DO229029	LICA	ICGC	DSGRGDS	DEG_SCF_TRCP1_1	70:76	Mutation altering degron motif	0.7532
p.S80I	SIDM00443	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGRGDS	DEG_SCF_TRCP1_1	70:76	Mutation blocking phosphorylation signal	0.6667
p.S80I	ACH-000287	Lymphoma	CCLE	DSGRGDS	DEG_SCF_TRCP1_1	70:76	Mutation blocking phosphorylation signal	0.6667
p.S80I	NU-DUL-1	haematopoietic and lymphoid tissue	COSMIC	DSGRGDS	DEG_SCF_TRCP1_1	70:76	Mutation blocking phosphorylation signal	0.6667
p.R69W	SIDM00451	T-Lymphoblastic Leukemia	GDSC	DSGRGDS	DEG_SCF_TRCP1_1	70:76	Mutation rewiring degron network	0.3056
p.R69W	PF-382	haematopoietic and lymphoid tissue	COSMIC	DSGRGDS	DEG_SCF_TRCP1_1	70:76	Mutation rewiring degron network	0.3056
p.S69I	NU-DUL-1	haematopoietic and lymphoid tissue	COSMIC	DSGRGDS	DEG_SCF_TRCP1_1	70:76	Mutation rewiring degron network	0.3056

Kaplan plot for PDCD4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PDCD4

UniProt ID: Q53EL6

Entrez ID: 27250

Protein name: Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PDCD4 in