DegronMD - Q96JE7(SEC16B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L967V	TCGA-04-1357	OV	TCGA	LSLTPSPE	DEG_SCF_FBW7_2	956:963	Mutation rewiring degron network	0.2222
p.L967V	DO27980	OV	ICGC	LSLTPSPE	DEG_SCF_FBW7_2	956:963	Mutation rewiring degron network	0.2222
p.R152L	TCGA-05-4396	LUAD	TCGA	DYR	CBL_MET	150:152	Mutation altering degron motif	0.8428
p.R152L	DO23838	LUAD	ICGC	DYR	CBL_MET	150:152	Mutation altering degron motif	0.8428
p.P968L	TCGA-09-1674	OV	TCGA	LSLTPSPE	DEG_SCF_FBW7_2	956:963	Mutation rewiring degron network	0.1944
p.P968L	DO31050	OV	ICGC	LSLTPSPE	DEG_SCF_FBW7_2	956:963	Mutation rewiring degron network	0.1944
p.R152Q	TCGA-AP-A056	UCEC	TCGA	DYR	CBL_MET	150:152	Mutation altering degron motif	0.7329
p.R152Q	DO43971	UCEC	ICGC	DYR	CBL_MET	150:152	Mutation altering degron motif	0.7329
p.E149K	TCGA-AX-A05Z	UCEC	TCGA	DYR	CBL_MET	150:152	Mutation rewiring degron network	0.3056
p.E149K	TCGA-CV-7250	HNSC	TCGA	DYR	CBL_MET	150:152	Mutation rewiring degron network	0.3056
p.E149K	DO15070	HNSC	ICGC	DYR	CBL_MET	150:152	Mutation rewiring degron network	0.3056
p.E149K	DO40884	UCEC	ICGC	DYR	CBL_MET	150:152	Mutation rewiring degron network	0.3056
p.S143I	TCGA-B5-A3FC	UCEC	TCGA	DYR	CBL_MET	150:152	Mutation blocking phosphorylation signal	0.5833
p.S143I	DO41871	UCEC	ICGC	DYR	CBL_MET	150:152	Mutation blocking phosphorylation signal	0.5833
p.R142Q	TCGA-B5-A3FC	UCEC	TCGA	DYR	CBL_MET	150:152	Mutation rewiring degron network	0.1111
p.R142Q	DO41871	UCEC	ICGC	DYR	CBL_MET	150:152	Mutation rewiring degron network	0.1111
p.R142Q	SIDM00449	B-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	150:152	Mutation rewiring degron network	0.1111
p.R142Q	ACH-000922	Leukemia	CCLE	DYR	CBL_MET	150:152	Mutation rewiring degron network	0.1111
p.R142Q	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	150:152	Mutation rewiring degron network	0.1111
p.H950R	TCGA-B8-5549	KIRC	TCGA	LSLTPSPE	DEG_SCF_FBW7_2	956:963	Mutation rewiring degron network	0.1667
p.H950R	DO20446	KIRC	ICGC	LSLTPSPE	DEG_SCF_FBW7_2	956:963	Mutation rewiring degron network	0.1667
p.L954M	DO230342	COCA	ICGC	LSLTPSPE	DEG_SCF_FBW7_2	956:963	Mutation rewiring degron network	0.2778
p.D969G	DO222846	COCA	ICGC	LSLTPSPE	DEG_SCF_FBW7_2	956:963	Mutation rewiring degron network	0.1667
p.G955V	DO233267	GACA	ICGC	LSLTPSPE	DEG_SCF_FBW7_2	956:963	Mutation rewiring degron network	0.3056
p.H160N	DO229027	LICA	ICGC	DYR	CBL_MET	150:152	Mutation rewiring degron network	0.1111
p.S964Y	DO229036	LICA	ICGC	LSLTPSPE	DEG_SCF_FBW7_2	956:963	Mutation rewiring degron network	0.3056
p.G955C	DO25104	LUAD	ICGC	LSLTPSPE	DEG_SCF_FBW7_2	956:963	Mutation rewiring degron network	0.3056
p.S957L	DO50657	ORCA	ICGC	LSLTPSPE	DEG_SCF_FBW7_2	956:963	Mutation altering degron motif	0.7667
p.P949S	DO218900	SKCA	ICGC	LSLTPSPE	DEG_SCF_FBW7_2	956:963	Mutation rewiring degron network	0.1389
p.G955D	SIDM01293	Colorectal Carcinoma	GDSC	LSLTPSPE	DEG_SCF_FBW7_2	956:963	Mutation rewiring degron network	0.3056
p.S947C	SIDM02034	Colorectal Carcinoma	GDSC	LSLTPSPE	DEG_SCF_FBW7_2	956:963	Mutation rewiring degron network	0.0833
p.S143N	SIDM00216	Colorectal Carcinoma	GDSC	DYR	CBL_MET	150:152	Mutation blocking phosphorylation signal	0.5833
p.S143N	ACH-000989	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	150:152	Mutation blocking phosphorylation signal	0.5833
p.S143N	SNU-175	large intestine	COSMIC	DYR	CBL_MET	150:152	Mutation blocking phosphorylation signal	0.5833
p.S947T	SIDM00080	Melanoma	GDSC	LSLTPSPE	DEG_SCF_FBW7_2	956:963	Mutation rewiring degron network	0.0833
p.S947T	ACH-000730	Skin Cancer	CCLE	LSLTPSPE	DEG_SCF_FBW7_2	956:963	Mutation rewiring degron network	0.0833
p.S947T	SK-MEL-5	skin	COSMIC	LSLTPSPE	DEG_SCF_FBW7_2	956:963	Mutation rewiring degron network	0.0833
p.H161Y	SIDM00184	Melanoma	GDSC	DYR	CBL_MET	150:152	Mutation rewiring degron network	0.0833
p.H161Y	ACH-002153	Skin Cancer	CCLE	DYR	CBL_MET	150:152	Mutation rewiring degron network	0.0833
p.H161Y	LB373-MEL-D	skin	COSMIC	DYR	CBL_MET	150:152	Mutation rewiring degron network	0.0833

Kaplan plot for SEC16B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SEC16B

UniProt ID: Q96JE7

Entrez ID: 89866

Protein name: Protein transport protein Sec16B (Leucine zipper transcription regulator 2) (Regucalcin gene promoter region-related protein p117) (RGPR-p117) (SEC16 homolog B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SEC16B in