DegronMD

Uniprot ID: Q96JE7

Source protein: Protein transport protein Sec16B

Source gene: SEC16B

Class: DEG_SCF_FBW7_2

Location: 956:963

E3 ligase: FBXW7

DEGRON score: 0.9931

ASA_SCORE: 93.8125

COIL: 0.9571

CONS_SCORE: 0.4426

DSS_SCORE: 0.7808

HELIX: 0.019

FCONS_SCORE: 1.4358

RIG_SCORE: 0.5629

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L967V	TCGA-04-1357	OV	TCGA	LSLTPSPE	DEG_SCF_FBW7_2	0.2222
p.L967V	DO27980	OV	ICGC	LSLTPSPE	DEG_SCF_FBW7_2	0.2222
p.P968L	TCGA-09-1674	OV	TCGA	LSLTPSPE	DEG_SCF_FBW7_2	0.1944
p.P968L	DO31050	OV	ICGC	LSLTPSPE	DEG_SCF_FBW7_2	0.1944
p.H950R	TCGA-B8-5549	KIRC	TCGA	LSLTPSPE	DEG_SCF_FBW7_2	0.1667
p.H950R	DO20446	KIRC	ICGC	LSLTPSPE	DEG_SCF_FBW7_2	0.1667
p.L954M	DO230342	COCA	ICGC	LSLTPSPE	DEG_SCF_FBW7_2	0.2778
p.D969G	DO222846	COCA	ICGC	LSLTPSPE	DEG_SCF_FBW7_2	0.1667
p.G955V	DO233267	GACA	ICGC	LSLTPSPE	DEG_SCF_FBW7_2	0.3056
p.S964Y	DO229036	LICA	ICGC	LSLTPSPE	DEG_SCF_FBW7_2	0.3056
p.G955C	DO25104	LUAD	ICGC	LSLTPSPE	DEG_SCF_FBW7_2	0.3056
p.S957L	DO50657	ORCA	ICGC	LSLTPSPE	DEG_SCF_FBW7_2	0.7667
p.P949S	DO218900	SKCA	ICGC	LSLTPSPE	DEG_SCF_FBW7_2	0.1389
p.G955D	SIDM01293	Colorectal Carcinoma	GDSC	LSLTPSPE	DEG_SCF_FBW7_2	0.3056
p.S947C	SIDM02034	Colorectal Carcinoma	GDSC	LSLTPSPE	DEG_SCF_FBW7_2	0.0833
p.S947T	SIDM00080	Melanoma	GDSC	LSLTPSPE	DEG_SCF_FBW7_2	0.0833
p.S947T	ACH-000730	Skin Cancer	CCLE	LSLTPSPE	DEG_SCF_FBW7_2	0.0833
p.S947T	SK-MEL-5	skin	COSMIC	LSLTPSPE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JE7	Protein transport protein Sec16B	DEG_SCF_FBW7_2	956:963	LSLTPSPE	FBXW7	0.9931	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons