DegronMD - Q96JE9(MAP6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H509N	TCGA-AP-A1DV	UCEC	TCGA	DQDHTVPEP	DEG_COP1_1	506:514	Mutation altering degron motif	0.6312
p.H509N	TCGA-QF-A5YS	UCEC	TCGA	DQDHTVPEP	DEG_COP1_1	506:514	Mutation altering degron motif	0.6312
p.H509N	DO43186	UCEC	ICGC	DQDHTVPEP	DEG_COP1_1	506:514	Mutation altering degron motif	0.6312
p.H509N	DO52426	UCEC	ICGC	DQDHTVPEP	DEG_COP1_1	506:514	Mutation altering degron motif	0.6312
p.D508E	TCGA-AX-A2HC	UCEC	TCGA	DQDHTVPEP	DEG_COP1_1	506:514	Mutation altering degron motif	0.5647
p.D508E	DO41572	UCEC	ICGC	DQDHTVPEP	DEG_COP1_1	506:514	Mutation altering degron motif	0.5647
p.A307T	TCGA-EE-A2GJ	SKCM	TCGA	AVSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.1389
p.A307T	DO37746	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.1389
p.E304K	TCGA-EY-A215	UCEC	TCGA	AVSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.2222
p.E304K	DO42665	UCEC	ICGC	AVSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.2222
p.E304K	SIDM00007	Other Solid Cancers	GDSC	AVSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.2222
p.E304K	ACH-001550	Skin Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.2222
p.E304K	MCC13	skin	COSMIC	AVSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.2222
p.H509R	TCGA-EY-A2OP	UCEC	TCGA	DQDHTVPEP	DEG_COP1_1	506:514	Mutation altering degron motif	0.7133
p.H509R	DO42560	UCEC	ICGC	DQDHTVPEP	DEG_COP1_1	506:514	Mutation altering degron motif	0.7133
p.G497S	TCGA-EY-A2OP	UCEC	TCGA	DQDHTVPEP	DEG_COP1_1	506:514	Mutation rewiring degron network	0.0833
p.G497S	DO42560	UCEC	ICGC	DQDHTVPEP	DEG_COP1_1	506:514	Mutation rewiring degron network	0.0833
p.S119L	DO233088	GACA	ICGC	DYR	CBL_MET	124:126	Mutation rewiring degron network	0.1944
p.A524E	DO229022	LICA	ICGC	DQDHTVPEP	DEG_COP1_1	506:514	Mutation rewiring degron network	0.0556
p.R132L	DO38404	STAD	ICGC	DYR	CBL_MET	124:126	Mutation rewiring degron network	0.1667
p.M121I	DO230449	UTCA	ICGC	DYR	CBL_MET	124:126	Mutation rewiring degron network	0.25
p.V297M	SIDM01962	Colorectal Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	296:300	Mutation altering degron motif	0.6097
p.R290H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	AVSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.1667
p.E291D	SIDM00465	Ovarian Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.1944
p.V504L	SIDM00220	Ovarian Carcinoma	GDSC	DQDHTVPEP	DEG_COP1_1	506:514	Mutation rewiring degron network	0.2778
p.V504L	OC-314	ovary	COSMIC	DQDHTVPEP	DEG_COP1_1	506:514	Mutation rewiring degron network	0.2778
p.A294S	ACH-000884	Skin Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.2778
p.G287D	SK-GT-4	oesophagus	COSMIC	AVSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.0833
p.E288Q	SK-GT-4	oesophagus	COSMIC	AVSSS	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.1111

Kaplan plot for MAP6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAP6

UniProt ID: Q96JE9

Entrez ID: 4135

Protein name: Microtubule-associated protein 6 (MAP-6) (Stable tubule-only polypeptide) (STOP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAP6 in