DegronMD

Uniprot ID: Q96JE9

Source protein: Microtubule-associated protein 6

Source gene: MAP6

Class: DEG_COP1_1

Location: 506:514

E3 ligase: COP1

DEGRON score: 0.9805

ASA_SCORE: 102.5556

COIL: 0.963

CONS_SCORE: 0.368

DSS_SCORE: 0.6652

HELIX: 0.0182

FCONS_SCORE: 0.9474

RIG_SCORE: 0.6843

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H509R	TCGA-EY-A2OP	UCEC	TCGA	DQDHTVPEP	DEG_COP1_1	0.7133
p.H509R	DO42560	UCEC	ICGC	DQDHTVPEP	DEG_COP1_1	0.7133
p.H509N	TCGA-AP-A1DV	UCEC	TCGA	DQDHTVPEP	DEG_COP1_1	0.6312
p.H509N	TCGA-QF-A5YS	UCEC	TCGA	DQDHTVPEP	DEG_COP1_1	0.6312
p.H509N	DO43186	UCEC	ICGC	DQDHTVPEP	DEG_COP1_1	0.6312
p.H509N	DO52426	UCEC	ICGC	DQDHTVPEP	DEG_COP1_1	0.6312
p.D508E	TCGA-AX-A2HC	UCEC	TCGA	DQDHTVPEP	DEG_COP1_1	0.5647
p.D508E	DO41572	UCEC	ICGC	DQDHTVPEP	DEG_COP1_1	0.5647
p.V504L	SIDM00220	Ovarian Carcinoma	GDSC	DQDHTVPEP	DEG_COP1_1	0.2778
p.V504L	OC-314	ovary	COSMIC	DQDHTVPEP	DEG_COP1_1	0.2778
p.G497S	TCGA-EY-A2OP	UCEC	TCGA	DQDHTVPEP	DEG_COP1_1	0.0833
p.G497S	DO42560	UCEC	ICGC	DQDHTVPEP	DEG_COP1_1	0.0833
p.A524E	DO229022	LICA	ICGC	DQDHTVPEP	DEG_COP1_1	0.0556

Showing 1 to 13 of 13 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JE9	Microtubule-associated protein 6	DEG_COP1_1	506:514	DQDHTVPEP	COP1	0.9805	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons