DegronMD - Q9H270(VPS11)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G565E	TCGA-13-0885	OV	TCGA	DYR	CBL_MET	570:572	Mutation blocking ubiquitination signal	0.6389
p.G565E	DO30490	OV	ICGC	DYR	CBL_MET	570:572	Mutation blocking ubiquitination signal	0.6389
p.R289W	TCGA-A5-A0G2	UCEC	TCGA	FRGYLIIVS	DEG_APCC_DBOX_1	279:287	Mutation rewiring degron network	0.2778
p.R289W	DO41235	UCEC	ICGC	FRGYLIIVS	DEG_APCC_DBOX_1	279:287	Mutation rewiring degron network	0.2778
p.R289W	ACH-000508	Lung Cancer	CCLE	FRGYLIIVS	DEG_APCC_DBOX_1	279:287	Mutation rewiring degron network	0.2778
p.D579N	TCGA-AA-3821	COAD	TCGA	DYR	CBL_MET	570:572	Mutation rewiring degron network	0.1389
p.D579N	DO9314	COAD	ICGC	DYR	CBL_MET	570:572	Mutation rewiring degron network	0.1389
p.D579N	DO227549	COCA	ICGC	DYR	CBL_MET	570:572	Mutation rewiring degron network	0.1389
p.R287S	TCGA-CK-5916	COAD	TCGA	FRGYLIIVS	DEG_APCC_DBOX_1	279:287	Mutation altering degron motif	0.7427
p.R287S	DO8786	COAD	ICGC	FRGYLIIVS	DEG_APCC_DBOX_1	279:287	Mutation altering degron motif	0.7427
p.V285F	TCGA-D3-A2JC	SKCM	TCGA	FRGYLIIVS	DEG_APCC_DBOX_1	279:287	Mutation altering degron motif	0.7068
p.V285F	DO47578	SKCM	ICGC	FRGYLIIVS	DEG_APCC_DBOX_1	279:287	Mutation altering degron motif	0.7068
p.R287C	TCGA-EQ-A4SO	STAD	TCGA	FRGYLIIVS	DEG_APCC_DBOX_1	279:287	Mutation altering degron motif	0.8301
p.R287C	DO47893	STAD	ICGC	FRGYLIIVS	DEG_APCC_DBOX_1	279:287	Mutation altering degron motif	0.8301
p.P21S	DO233129	GACA	ICGC	RRFVFFD	LIG_APCC_ABBAyCdc20_2	8:14	Mutation rewiring degron network	0.1389
p.R287H	DO233764	GACA	ICGC	FRGYLIIVS	DEG_APCC_DBOX_1	279:287	Mutation altering degron motif	0.8244
p.D14E	SIDM00845	Burkitt's Lymphoma	GDSC	RRFVFFD	LIG_APCC_ABBAyCdc20_2	8:14	Mutation altering degron motif	0.5647
p.A12P	SIDM00845	Burkitt's Lymphoma	GDSC	RRFVFFD	LIG_APCC_ABBAyCdc20_2	8:14	Mutation altering degron motif	0.7503
p.A12P	SIDM00721	Small Cell Lung Carcinoma	GDSC	RRFVFFD	LIG_APCC_ABBAyCdc20_2	8:14	Mutation altering degron motif	0.7503
p.I284V	SIDM00845	Burkitt's Lymphoma	GDSC	FRGYLIIVS	DEG_APCC_DBOX_1	279:287	Mutation altering degron motif	0.5965
p.L567F	SIDM00789	Colorectal Carcinoma	GDSC	DYR	CBL_MET	570:572	Mutation rewiring degron network	0.25
p.L567F	HCT-15	large intestine	COSMIC	DYR	CBL_MET	570:572	Mutation rewiring degron network	0.25
p.R290W	SIDM00506	Small Cell Lung Carcinoma	GDSC	FRGYLIIVS	DEG_APCC_DBOX_1	279:287	Mutation rewiring degron network	0.25
p.L274H	SIDM01259	B-Lymphoblastic Leukemia	GDSC	FRGYLIIVS	DEG_APCC_DBOX_1	279:287	Mutation rewiring degron network	0.1944
p.R6L	SIDM00526	Chronic Myelogenous Leukemia	GDSC	RRFVFFD	LIG_APCC_ABBAyCdc20_2	8:14	Mutation rewiring degron network	0.2778
p.R6L	MEG-01	haematopoietic and lymphoid tissue	COSMIC	RRFVFFD	LIG_APCC_ABBAyCdc20_2	8:14	Mutation rewiring degron network	0.2778
p.R288C	SIDM00168	Head and Neck Carcinoma	GDSC	FRGYLIIVS	DEG_APCC_DBOX_1	279:287	Mutation rewiring degron network	0.3056
p.G280D	ACH-000028	Breast Cancer	CCLE	FRGYLIIVS	DEG_APCC_DBOX_1	279:287	Mutation altering degron motif	0.7198
p.L566F	ACH-000997	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	570:572	Mutation rewiring degron network	0.2222
p.L23F	HCT-15	large intestine	COSMIC	RRFVFFD	LIG_APCC_ABBAyCdc20_2	8:14	Mutation rewiring degron network	0.0833
p.G5V	HCT-15	large intestine	COSMIC	RRFVFFD	LIG_APCC_ABBAyCdc20_2	8:14	Mutation rewiring degron network	0.25

Kaplan plot for VPS11 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VPS11

UniProt ID: Q9H270

Entrez ID: 55823

Protein name: Vacuolar protein sorting-associated protein 11 homolog (hVPS11) (RING finger protein 108)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VPS11 in