DegronMD

Uniprot ID: Q9H270

Source protein: Vacuolar protein sorting-associated protein 11 homolog

Source gene: VPS11

Class: LIG_APCC_ABBAyCdc20_2

Location: 8:14

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9134

ASA_SCORE: 71.7429

COIL: 0.5901

CONS_SCORE: 0.4846

DSS_SCORE: 0.0762

HELIX: 0.0213

FCONS_SCORE: 1.6695

RIG_SCORE: 0.9596

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P21S	DO233129	GACA	ICGC	RRFVFFD	LIG_APCC_ABBAyCdc20_2	0.1389
p.D14E	SIDM00845	Burkitt's Lymphoma	GDSC	RRFVFFD	LIG_APCC_ABBAyCdc20_2	0.5647
p.A12P	SIDM00845	Burkitt's Lymphoma	GDSC	RRFVFFD	LIG_APCC_ABBAyCdc20_2	0.7503
p.A12P	SIDM00721	Small Cell Lung Carcinoma	GDSC	RRFVFFD	LIG_APCC_ABBAyCdc20_2	0.7503
p.R6L	SIDM00526	Chronic Myelogenous Leukemia	GDSC	RRFVFFD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R6L	MEG-01	haematopoietic_and_lymphoid_tissue	COSMIC	RRFVFFD	LIG_APCC_ABBAyCdc20_2	0.2778
p.L23F	HCT-15	large_intestine	COSMIC	RRFVFFD	LIG_APCC_ABBAyCdc20_2	0.0833
p.G5V	HCT-15	large_intestine	COSMIC	RRFVFFD	LIG_APCC_ABBAyCdc20_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H270	Vacuolar protein sorting-associated protein 11 homolog	LIG_APCC_ABBAyCdc20_2	8:14	RRFVFFD	APC,CDC20,FZR1	0.9134	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons