DegronMD

Uniprot ID: Q9H270

Source protein: Vacuolar protein sorting-associated protein 11 homolog

Source gene: VPS11

Class: DEG_APCC_DBOX_1

Location: 279:287

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7764

ASA_SCORE: 26.2222

COIL: 0.2593

CONS_SCORE: 0.4117

DSS_SCORE: 0.0811

HELIX: 0.0049

FCONS_SCORE: 1.3838

RIG_SCORE: 0.9221

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R289W	TCGA-A5-A0G2	UCEC	TCGA	FRGYLIIVS	DEG_APCC_DBOX_1	0.2778
p.R289W	DO41235	UCEC	ICGC	FRGYLIIVS	DEG_APCC_DBOX_1	0.2778
p.R289W	ACH-000508	Lung Cancer	CCLE	FRGYLIIVS	DEG_APCC_DBOX_1	0.2778
p.R287S	TCGA-CK-5916	COAD	TCGA	FRGYLIIVS	DEG_APCC_DBOX_1	0.7427
p.R287S	DO8786	COAD	ICGC	FRGYLIIVS	DEG_APCC_DBOX_1	0.7427
p.V285F	TCGA-D3-A2JC	SKCM	TCGA	FRGYLIIVS	DEG_APCC_DBOX_1	0.7068
p.V285F	DO47578	SKCM	ICGC	FRGYLIIVS	DEG_APCC_DBOX_1	0.7068
p.R287C	TCGA-EQ-A4SO	STAD	TCGA	FRGYLIIVS	DEG_APCC_DBOX_1	0.8301
p.R287C	DO47893	STAD	ICGC	FRGYLIIVS	DEG_APCC_DBOX_1	0.8301
p.R287H	DO233764	GACA	ICGC	FRGYLIIVS	DEG_APCC_DBOX_1	0.8244
p.I284V	SIDM00845	Burkitt's Lymphoma	GDSC	FRGYLIIVS	DEG_APCC_DBOX_1	0.5965
p.R290W	SIDM00506	Small Cell Lung Carcinoma	GDSC	FRGYLIIVS	DEG_APCC_DBOX_1	0.25
p.L274H	SIDM01259	B-Lymphoblastic Leukemia	GDSC	FRGYLIIVS	DEG_APCC_DBOX_1	0.1944
p.R288C	SIDM00168	Head and Neck Carcinoma	GDSC	FRGYLIIVS	DEG_APCC_DBOX_1	0.3056
p.G280D	ACH-000028	Breast Cancer	CCLE	FRGYLIIVS	DEG_APCC_DBOX_1	0.7198

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H270	Vacuolar protein sorting-associated protein 11 homolog	DEG_APCC_DBOX_1	279:287	FRGYLIIVS	APC,CDC20,FZR1	0.7764	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons