DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
FRGYLIIVS
Uniprot ID:
Q9H270
Source protein:
Vacuolar protein sorting-associated protein 11 homolog
Source gene:
VPS11
Class:
DEG_APCC_DBOX_1
Location:
279:287
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7764
ASA_SCORE:
26.2222
COIL:
0.2593
CONS_SCORE:
0.4117
DSS_SCORE:
0.0811
HELIX:
0.0049
FCONS_SCORE:
1.3838
RIG_SCORE:
0.9221
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R287C
TCGA-EQ-A4SO
STAD
TCGA
FRGYLIIVS
DEG_APCC_DBOX_1
0.8301
p.R287C
DO47893
STAD
ICGC
FRGYLIIVS
DEG_APCC_DBOX_1
0.8301
p.R287H
DO233764
GACA
ICGC
FRGYLIIVS
DEG_APCC_DBOX_1
0.8244
p.R287S
TCGA-CK-5916
COAD
TCGA
FRGYLIIVS
DEG_APCC_DBOX_1
0.7427
p.R287S
DO8786
COAD
ICGC
FRGYLIIVS
DEG_APCC_DBOX_1
0.7427
p.G280D
ACH-000028
Breast Cancer
CCLE
FRGYLIIVS
DEG_APCC_DBOX_1
0.7198
p.V285F
TCGA-D3-A2JC
SKCM
TCGA
FRGYLIIVS
DEG_APCC_DBOX_1
0.7068
p.V285F
DO47578
SKCM
ICGC
FRGYLIIVS
DEG_APCC_DBOX_1
0.7068
p.I284V
SIDM00845
Burkitt's Lymphoma
GDSC
FRGYLIIVS
DEG_APCC_DBOX_1
0.5965
p.R288C
SIDM00168
Head and Neck Carcinoma
GDSC
FRGYLIIVS
DEG_APCC_DBOX_1
0.3056
p.R289W
TCGA-A5-A0G2
UCEC
TCGA
FRGYLIIVS
DEG_APCC_DBOX_1
0.2778
p.R289W
DO41235
UCEC
ICGC
FRGYLIIVS
DEG_APCC_DBOX_1
0.2778
p.R289W
ACH-000508
Lung Cancer
CCLE
FRGYLIIVS
DEG_APCC_DBOX_1
0.2778
p.R290W
SIDM00506
Small Cell Lung Carcinoma
GDSC
FRGYLIIVS
DEG_APCC_DBOX_1
0.25
p.L274H
SIDM01259
B-Lymphoblastic Leukemia
GDSC
FRGYLIIVS
DEG_APCC_DBOX_1
0.1944
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Drug responses associated with VPS11 mutations
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Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of FRGYLIIVS
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H270
Vacuolar protein sorting-associated protein 11 homolog
DEG_APCC_DBOX_1
279:287
FRGYLIIVS
APC,CDC20,FZR1
0.7764
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