DegronMD - Q8N944(AMER3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A410T	TCGA-06-5413	GBM	TCGA	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation altering degron motif	0.6028
p.A410T	DO11711	GBM	ICGC	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation altering degron motif	0.6028
p.A410T	DO232761	PBCA	ICGC	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation altering degron motif	0.6028
p.S246L	TCGA-3B-A9HX	SARC	TCGA	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.0556
p.S246L	TCGA-AP-A0LM	UCEC	TCGA	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.0556
p.S246L	DO219937	SARC	ICGC	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.0556
p.S246L	DO43306	UCEC	ICGC	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.0556
p.S246L	SIDM00781	Colorectal Carcinoma	GDSC	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.0556
p.S246L	SIDM00780	Colorectal Carcinoma	GDSC	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.0556
p.S246L	ACH-000967	Colon/Colorectal Cancer	CCLE	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.0556
p.S246L	ACH-001199	Colon/Colorectal Cancer	CCLE	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.0556
p.S246L	SNU-C2B	large intestine	COSMIC	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.0556
p.P272S	TCGA-55-A4DG	LUAD	TCGA	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.0833
p.P272S	DO26337	LUAD	ICGC	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.0833
p.P272S	SIDM00673	Breast Carcinoma	GDSC	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.0833
p.P272S	ACH-000668	Breast Cancer	CCLE	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.0833
p.P272S	HCC70	breast	COSMIC	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.0833
p.D420Y	TCGA-64-1676	LUAD	TCGA	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation rewiring degron network	0.0833
p.D420Y	DO23629	LUAD	ICGC	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation rewiring degron network	0.0833
p.T407I	TCGA-95-7043	LUAD	TCGA	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation altering degron motif	0.7078
p.T407I	DO24739	LUAD	ICGC	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation altering degron motif	0.7078
p.P269L	TCGA-A6-2671	COAD	TCGA	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.1667
p.P269L	DO8087	COAD	ICGC	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.1667
p.S259L	TCGA-AA-3984	COAD	TCGA	DESSVPSL	DEG_COP1_1	256:263	Mutation altering degron motif	0.6556
p.S259L	TCGA-D3-A8GM	SKCM	TCGA	DESSVPSL	DEG_COP1_1	256:263	Mutation altering degron motif	0.6556
p.S259L	DO9002	COAD	ICGC	DESSVPSL	DEG_COP1_1	256:263	Mutation altering degron motif	0.6556
p.S259L	DO50288	SKCM	ICGC	DESSVPSL	DEG_COP1_1	256:263	Mutation altering degron motif	0.6556
p.S259L	SIDM00118	Colorectal Carcinoma	GDSC	DESSVPSL	DEG_COP1_1	256:263	Mutation altering degron motif	0.6556
p.S259L	ACH-001081	Colon/Colorectal Cancer	CCLE	DESSVPSL	DEG_COP1_1	256:263	Mutation altering degron motif	0.6556
p.S259L	HCC2998	large intestine	COSMIC	DESSVPSL	DEG_COP1_1	256:263	Mutation altering degron motif	0.6556
p.V253G	TCGA-AM-5821	COAD	TCGA	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.25
p.V253G	DO8240	COAD	ICGC	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.25
p.P134S	TCGA-AZ-6601	COAD	TCGA	DYR	CBL_MET	128:130	Mutation rewiring degron network	0.2222
p.P134S	DO8119	COAD	ICGC	DYR	CBL_MET	128:130	Mutation rewiring degron network	0.2222
p.P134S	SIDM00145	T-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	128:130	Mutation rewiring degron network	0.2222
p.P134S	ACH-001127	Leukemia	CCLE	DYR	CBL_MET	128:130	Mutation rewiring degron network	0.2222
p.P134S	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	128:130	Mutation rewiring degron network	0.2222
p.G406S	TCGA-B5-A11E	UCEC	TCGA	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation altering degron motif	0.5882
p.G406S	DO41644	UCEC	ICGC	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation altering degron motif	0.5882
p.E397D	TCGA-BR-7196	STAD	TCGA	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation rewiring degron network	0.1111
p.E397D	DO38235	STAD	ICGC	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation rewiring degron network	0.1111
p.S404G	TCGA-CG-5721	STAD	TCGA	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation rewiring degron network	0.3056
p.S404G	DO38192	STAD	ICGC	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation rewiring degron network	0.3056
p.Y129C	TCGA-D1-A15X	UCEC	TCGA	DYR	CBL_MET	128:130	Mutation altering degron motif	0.8198
p.Y129C	DO43274	UCEC	ICGC	DYR	CBL_MET	128:130	Mutation altering degron motif	0.8198
p.D415N	TCGA-D3-A8GQ	SKCM	TCGA	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation rewiring degron network	0.2222
p.D415N	DO51246	SKCM	ICGC	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation rewiring degron network	0.2222
p.S416I	TCGA-DX-A6YV	SARC	TCGA	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation rewiring degron network	0.1944
p.S416I	DO220011	SARC	ICGC	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation rewiring degron network	0.1944
p.R414Q	TCGA-E7-A6ME	BLCA	TCGA	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation rewiring degron network	0.25
p.R414Q	DO51874	BLCA	ICGC	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation rewiring degron network	0.25
p.P413T	TCGA-EE-A2GT	SKCM	TCGA	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation rewiring degron network	0.2778
p.P413T	DO37946	SKCM	ICGC	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation rewiring degron network	0.2778
p.D398N	TCGA-EE-A2MJ	SKCM	TCGA	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation rewiring degron network	0.1389
p.D398N	DO38099	SKCM	ICGC	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation rewiring degron network	0.1389
p.K399N	TCGA-EK-A3GJ	CESC	TCGA	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation substituting flanking lysine	0.2778
p.K399N	DO49962	CESC	ICGC	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation substituting flanking lysine	0.2778
p.S120F	TCGA-FW-A3R5	SKCM	TCGA	DYR	CBL_MET	128:130	Mutation blocking phosphorylation signal	0.5556
p.S120F	TCGA-XF-A9SJ	BLCA	TCGA	DYR	CBL_MET	128:130	Mutation blocking phosphorylation signal	0.5556
p.S120F	DO219045	BLCA	ICGC	DYR	CBL_MET	128:130	Mutation blocking phosphorylation signal	0.5556
p.S120F	DO37406	SKCM	ICGC	DYR	CBL_MET	128:130	Mutation blocking phosphorylation signal	0.5556
p.P405S	TCGA-G9-6384	PRAD	TCGA	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation altering degron motif	0.6752
p.P405S	DO36316	PRAD	ICGC	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation altering degron motif	0.6752
p.T273I	TCGA-GM-A2DH	BRCA	TCGA	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.0556
p.T273I	DO3317	BRCA	ICGC	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.0556
p.D256N	TCGA-GV-A3JZ	BLCA	TCGA	DESSVPSL	DEG_COP1_1	256:263	Mutation altering degron motif	0.6932
p.D256N	DO773	BLCA	ICGC	DESSVPSL	DEG_COP1_1	256:263	Mutation altering degron motif	0.6932
p.P413Q	TCGA-L4-A4E5	LUAD	TCGA	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation rewiring degron network	0.2778
p.P413Q	DO24320	LUAD	ICGC	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation rewiring degron network	0.2778
p.P261S	TCGA-XK-AAIW	PRAD	TCGA	DESSVPSL	DEG_COP1_1	256:263	Mutation altering degron motif	0.6752
p.P261S	DO51407	PRAD	ICGC	DESSVPSL	DEG_COP1_1	256:263	Mutation altering degron motif	0.6752
p.I127F	TCGA-Z2-A8RT	SKCM	TCGA	DYR	CBL_MET	128:130	Mutation rewiring degron network	0.3056
p.I127F	DO51301	SKCM	ICGC	DYR	CBL_MET	128:130	Mutation rewiring degron network	0.3056
p.D128G	DO227979	COCA	ICGC	DYR	CBL_MET	128:130	Mutation altering degron motif	0.7198
p.T273P	DO50411	ESAD	ICGC	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.0556
p.E401D	DO50339	ESAD	ICGC	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation rewiring degron network	0.2222
p.R130H	DO234390	ESAD	ICGC	DYR	CBL_MET	128:130	Mutation altering degron motif	0.8244
p.R130H	DO52684	MALY	ICGC	DYR	CBL_MET	128:130	Mutation altering degron motif	0.8244
p.R130H	SIDM01018	Hodgkin's Lymphoma	GDSC	DYR	CBL_MET	128:130	Mutation altering degron motif	0.8244
p.G406D	DO48211	ESCA	ICGC	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation altering degron motif	0.6087
p.E264D	DO228976	LICA	ICGC	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.3056
p.A410S	DO229029	LICA	ICGC	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation altering degron motif	0.6477
p.D128Y	DO229029	LICA	ICGC	DYR	CBL_MET	128:130	Mutation altering degron motif	0.7325
p.G251W	DO229037	LICA	ICGC	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.1944
p.P140Q	DO230538	LUSC	ICGC	DYR	CBL_MET	128:130	Mutation rewiring degron network	0.0556
p.S123R	DO52365	LUSC	ICGC	DYR	CBL_MET	128:130	Mutation rewiring degron network	0.1944
p.E257K	DO222402	MELA	ICGC	DESSVPSL	DEG_COP1_1	256:263	Mutation altering degron motif	0.7022
p.G251R	DO222837	MELA	ICGC	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.1944
p.H131Q	DO232761	PBCA	ICGC	DYR	CBL_MET	128:130	Mutation rewiring degron network	0.3056
p.G406V	SIDM02041	Colorectal Carcinoma	GDSC	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation altering degron motif	0.6421
p.T273S	SIDM01312	Esophageal Carcinoma	GDSC	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.0556
p.G122C	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	128:130	Mutation rewiring degron network	0.1667
p.G122C	ACH-000924	Lung Cancer	CCLE	DYR	CBL_MET	128:130	Mutation rewiring degron network	0.1667
p.G122C	NCI-H2172	lung	COSMIC	DYR	CBL_MET	128:130	Mutation rewiring degron network	0.1667
p.L395F	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation rewiring degron network	0.0556
p.G268S	SIDM01175	Other Sarcomas	GDSC	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.1944
p.G268S	ACH-002309	Sarcoma	CCLE	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.1944
p.G268S	SW684	soft tissue	COSMIC	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.1944
p.P408S	SIDM00007	Other Solid Cancers	GDSC	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation altering degron motif	0.6752
p.P408S	ACH-001550	Skin Cancer	CCLE	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation altering degron motif	0.6752
p.P408S	MCC13	skin	COSMIC	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation altering degron motif	0.6752
p.E267K	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.2222
p.E267K	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.2222
p.E267K	ACH-000912	Lung Cancer	CCLE	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.2222
p.E267K	H513	pleura	COSMIC	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.2222
p.A421T	SIDM00217	Colorectal Carcinoma	GDSC	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation rewiring degron network	0.0556
p.A421T	ACH-000999	Colon/Colorectal Cancer	CCLE	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation rewiring degron network	0.0556
p.A421T	SNU-1040	large intestine	COSMIC	PGTPAAT	DEG_SCF_FBW7_1	405:411	Mutation rewiring degron network	0.0556
p.S271T	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.1111
p.S271T	ACH-000717	Esophageal Cancer	CCLE	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.1111
p.S271T	COLO-680N	oesophagus	COSMIC	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.1111
p.P121T	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	128:130	Mutation rewiring degron network	0.1389
p.P121T	ACH-000869	Lung Cancer	CCLE	DYR	CBL_MET	128:130	Mutation rewiring degron network	0.1389
p.P121T	NCI-H1568	lung	COSMIC	DYR	CBL_MET	128:130	Mutation rewiring degron network	0.1389
p.E252D	SIDM01659	Kidney Carcinoma	GDSC	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.2222
p.E252D	ACH-000313	Kidney Cancer	CCLE	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.2222
p.P134A	ACH-001067	Brain Cancer	CCLE	DYR	CBL_MET	128:130	Mutation rewiring degron network	0.2222
p.R124Q	ACH-001134	Lymphoma	CCLE	DYR	CBL_MET	128:130	Mutation rewiring degron network	0.2222
p.L247F	ACH-001765	Sarcoma	CCLE	DESSVPSL	DEG_COP1_1	256:263	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AMER3

UniProt ID: Q8N944

Entrez ID: 205147

Protein name: APC membrane recruitment protein 3 (Amer3) (Protein FAM123C)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AMER3 in