DegronMD

Uniprot ID: Q8N944

Source protein: APC membrane recruitment protein 3

Source gene: AMER3

Class: DEG_COP1_1

Location: 256:263

E3 ligase: COP1

DEGRON score: 0.8531

ASA_SCORE: 70.875

COIL: 0.7804

CONS_SCORE: 0.8046

DSS_SCORE: 0.4978

HELIX: 0.1514

FCONS_SCORE: 0.973

RIG_SCORE: 0.7107

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S246L	TCGA-3B-A9HX	SARC	TCGA	DESSVPSL	DEG_COP1_1	0.0556
p.S246L	TCGA-AP-A0LM	UCEC	TCGA	DESSVPSL	DEG_COP1_1	0.0556
p.S246L	DO219937	SARC	ICGC	DESSVPSL	DEG_COP1_1	0.0556
p.S246L	DO43306	UCEC	ICGC	DESSVPSL	DEG_COP1_1	0.0556
p.S246L	SIDM00781	Colorectal Carcinoma	GDSC	DESSVPSL	DEG_COP1_1	0.0556
p.S246L	SIDM00780	Colorectal Carcinoma	GDSC	DESSVPSL	DEG_COP1_1	0.0556
p.S246L	ACH-000967	Colon/Colorectal Cancer	CCLE	DESSVPSL	DEG_COP1_1	0.0556
p.S246L	ACH-001199	Colon/Colorectal Cancer	CCLE	DESSVPSL	DEG_COP1_1	0.0556
p.S246L	SNU-C2B	large_intestine	COSMIC	DESSVPSL	DEG_COP1_1	0.0556
p.P272S	TCGA-55-A4DG	LUAD	TCGA	DESSVPSL	DEG_COP1_1	0.0833
p.P272S	DO26337	LUAD	ICGC	DESSVPSL	DEG_COP1_1	0.0833
p.P272S	SIDM00673	Breast Carcinoma	GDSC	DESSVPSL	DEG_COP1_1	0.0833
p.P272S	ACH-000668	Breast Cancer	CCLE	DESSVPSL	DEG_COP1_1	0.0833
p.P272S	HCC70	breast	COSMIC	DESSVPSL	DEG_COP1_1	0.0833
p.P269L	TCGA-A6-2671	COAD	TCGA	DESSVPSL	DEG_COP1_1	0.1667
p.P269L	DO8087	COAD	ICGC	DESSVPSL	DEG_COP1_1	0.1667
p.S259L	TCGA-AA-3984	COAD	TCGA	DESSVPSL	DEG_COP1_1	0.6556
p.S259L	TCGA-D3-A8GM	SKCM	TCGA	DESSVPSL	DEG_COP1_1	0.6556
p.S259L	DO9002	COAD	ICGC	DESSVPSL	DEG_COP1_1	0.6556
p.S259L	DO50288	SKCM	ICGC	DESSVPSL	DEG_COP1_1	0.6556
p.S259L	SIDM00118	Colorectal Carcinoma	GDSC	DESSVPSL	DEG_COP1_1	0.6556
p.S259L	ACH-001081	Colon/Colorectal Cancer	CCLE	DESSVPSL	DEG_COP1_1	0.6556
p.S259L	HCC2998	large_intestine	COSMIC	DESSVPSL	DEG_COP1_1	0.6556
p.V253G	TCGA-AM-5821	COAD	TCGA	DESSVPSL	DEG_COP1_1	0.25
p.V253G	DO8240	COAD	ICGC	DESSVPSL	DEG_COP1_1	0.25
p.T273I	TCGA-GM-A2DH	BRCA	TCGA	DESSVPSL	DEG_COP1_1	0.0556
p.T273I	DO3317	BRCA	ICGC	DESSVPSL	DEG_COP1_1	0.0556
p.D256N	TCGA-GV-A3JZ	BLCA	TCGA	DESSVPSL	DEG_COP1_1	0.6932
p.D256N	DO773	BLCA	ICGC	DESSVPSL	DEG_COP1_1	0.6932
p.P261S	TCGA-XK-AAIW	PRAD	TCGA	DESSVPSL	DEG_COP1_1	0.6752
p.P261S	DO51407	PRAD	ICGC	DESSVPSL	DEG_COP1_1	0.6752
p.T273P	DO50411	ESAD	ICGC	DESSVPSL	DEG_COP1_1	0.0556
p.E264D	DO228976	LICA	ICGC	DESSVPSL	DEG_COP1_1	0.3056
p.G251W	DO229037	LICA	ICGC	DESSVPSL	DEG_COP1_1	0.1944
p.E257K	DO222402	MELA	ICGC	DESSVPSL	DEG_COP1_1	0.7022
p.G251R	DO222837	MELA	ICGC	DESSVPSL	DEG_COP1_1	0.1944
p.T273S	SIDM01312	Esophageal Carcinoma	GDSC	DESSVPSL	DEG_COP1_1	0.0556
p.G268S	SIDM01175	Other Sarcomas	GDSC	DESSVPSL	DEG_COP1_1	0.1944
p.G268S	ACH-002309	Sarcoma	CCLE	DESSVPSL	DEG_COP1_1	0.1944
p.G268S	SW684	soft_tissue	COSMIC	DESSVPSL	DEG_COP1_1	0.1944
p.E267K	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	DESSVPSL	DEG_COP1_1	0.2222
p.E267K	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	DESSVPSL	DEG_COP1_1	0.2222
p.E267K	ACH-000912	Lung Cancer	CCLE	DESSVPSL	DEG_COP1_1	0.2222
p.E267K	H513	pleura	COSMIC	DESSVPSL	DEG_COP1_1	0.2222
p.S271T	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	DESSVPSL	DEG_COP1_1	0.1111
p.S271T	ACH-000717	Esophageal Cancer	CCLE	DESSVPSL	DEG_COP1_1	0.1111
p.S271T	COLO-680N	oesophagus	COSMIC	DESSVPSL	DEG_COP1_1	0.1111
p.E252D	SIDM01659	Kidney Carcinoma	GDSC	DESSVPSL	DEG_COP1_1	0.2222
p.E252D	ACH-000313	Kidney Cancer	CCLE	DESSVPSL	DEG_COP1_1	0.2222
p.L247F	ACH-001765	Sarcoma	CCLE	DESSVPSL	DEG_COP1_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DESSVPSL

Degron related mutations and impact score

Drug responses associated with AMER3 mutations

All proteins holding degron of DESSVPSL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N944	APC membrane recruitment protein 3	DEG_COP1_1	256:263	DESSVPSL	COP1	0.8531	More...