DegronMD

Uniprot ID: Q8N944

Source protein: APC membrane recruitment protein 3

Source gene: AMER3

Class: DEG_SCF_FBW7_1

Location: 405:411

E3 ligase: FBXW7

DEGRON score: 0.9465

ASA_SCORE: 68.6

COIL: 0.9071

CONS_SCORE: 0.7165

DSS_SCORE: 0.6851

HELIX: 0.0403

FCONS_SCORE: 0.785

RIG_SCORE: 0.6276

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A410T	TCGA-06-5413	GBM	TCGA	PGTPAAT	DEG_SCF_FBW7_1	0.6028
p.A410T	DO11711	GBM	ICGC	PGTPAAT	DEG_SCF_FBW7_1	0.6028
p.A410T	DO232761	PBCA	ICGC	PGTPAAT	DEG_SCF_FBW7_1	0.6028
p.D420Y	TCGA-64-1676	LUAD	TCGA	PGTPAAT	DEG_SCF_FBW7_1	0.0833
p.D420Y	DO23629	LUAD	ICGC	PGTPAAT	DEG_SCF_FBW7_1	0.0833
p.T407I	TCGA-95-7043	LUAD	TCGA	PGTPAAT	DEG_SCF_FBW7_1	0.7078
p.T407I	DO24739	LUAD	ICGC	PGTPAAT	DEG_SCF_FBW7_1	0.7078
p.G406S	TCGA-B5-A11E	UCEC	TCGA	PGTPAAT	DEG_SCF_FBW7_1	0.5882
p.G406S	DO41644	UCEC	ICGC	PGTPAAT	DEG_SCF_FBW7_1	0.5882
p.E397D	TCGA-BR-7196	STAD	TCGA	PGTPAAT	DEG_SCF_FBW7_1	0.1111
p.E397D	DO38235	STAD	ICGC	PGTPAAT	DEG_SCF_FBW7_1	0.1111
p.S404G	TCGA-CG-5721	STAD	TCGA	PGTPAAT	DEG_SCF_FBW7_1	0.3056
p.S404G	DO38192	STAD	ICGC	PGTPAAT	DEG_SCF_FBW7_1	0.3056
p.D415N	TCGA-D3-A8GQ	SKCM	TCGA	PGTPAAT	DEG_SCF_FBW7_1	0.2222
p.D415N	DO51246	SKCM	ICGC	PGTPAAT	DEG_SCF_FBW7_1	0.2222
p.S416I	TCGA-DX-A6YV	SARC	TCGA	PGTPAAT	DEG_SCF_FBW7_1	0.1944
p.S416I	DO220011	SARC	ICGC	PGTPAAT	DEG_SCF_FBW7_1	0.1944
p.R414Q	TCGA-E7-A6ME	BLCA	TCGA	PGTPAAT	DEG_SCF_FBW7_1	0.25
p.R414Q	DO51874	BLCA	ICGC	PGTPAAT	DEG_SCF_FBW7_1	0.25
p.P413T	TCGA-EE-A2GT	SKCM	TCGA	PGTPAAT	DEG_SCF_FBW7_1	0.2778
p.P413T	DO37946	SKCM	ICGC	PGTPAAT	DEG_SCF_FBW7_1	0.2778
p.D398N	TCGA-EE-A2MJ	SKCM	TCGA	PGTPAAT	DEG_SCF_FBW7_1	0.1389
p.D398N	DO38099	SKCM	ICGC	PGTPAAT	DEG_SCF_FBW7_1	0.1389
p.K399N	TCGA-EK-A3GJ	CESC	TCGA	PGTPAAT	DEG_SCF_FBW7_1	0.2778
p.K399N	DO49962	CESC	ICGC	PGTPAAT	DEG_SCF_FBW7_1	0.2778
p.P405S	TCGA-G9-6384	PRAD	TCGA	PGTPAAT	DEG_SCF_FBW7_1	0.6752
p.P405S	DO36316	PRAD	ICGC	PGTPAAT	DEG_SCF_FBW7_1	0.6752
p.P413Q	TCGA-L4-A4E5	LUAD	TCGA	PGTPAAT	DEG_SCF_FBW7_1	0.2778
p.P413Q	DO24320	LUAD	ICGC	PGTPAAT	DEG_SCF_FBW7_1	0.2778
p.E401D	DO50339	ESAD	ICGC	PGTPAAT	DEG_SCF_FBW7_1	0.2222
p.G406D	DO48211	ESCA	ICGC	PGTPAAT	DEG_SCF_FBW7_1	0.6087
p.A410S	DO229029	LICA	ICGC	PGTPAAT	DEG_SCF_FBW7_1	0.6477
p.G406V	SIDM02041	Colorectal Carcinoma	GDSC	PGTPAAT	DEG_SCF_FBW7_1	0.6421
p.L395F	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	PGTPAAT	DEG_SCF_FBW7_1	0.0556
p.P408S	SIDM00007	Other Solid Cancers	GDSC	PGTPAAT	DEG_SCF_FBW7_1	0.6752
p.P408S	ACH-001550	Skin Cancer	CCLE	PGTPAAT	DEG_SCF_FBW7_1	0.6752
p.P408S	MCC13	skin	COSMIC	PGTPAAT	DEG_SCF_FBW7_1	0.6752
p.A421T	SIDM00217	Colorectal Carcinoma	GDSC	PGTPAAT	DEG_SCF_FBW7_1	0.0556
p.A421T	ACH-000999	Colon/Colorectal Cancer	CCLE	PGTPAAT	DEG_SCF_FBW7_1	0.0556
p.A421T	SNU-1040	large_intestine	COSMIC	PGTPAAT	DEG_SCF_FBW7_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGTPAAT

Degron related mutations and impact score

Drug responses associated with AMER3 mutations

All proteins holding degron of PGTPAAT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N944	APC membrane recruitment protein 3	DEG_SCF_FBW7_1	405:411	PGTPAAT	FBXW7	0.9465	More...