DegronMD - Q8NEY8(PPHLN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S213Y	TCGA-A8-A094	BRCA	TCGA	AVSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.712
p.S213Y	TCGA-E6-A1LX	UCEC	TCGA	AVSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.712
p.S213Y	DO2593	BRCA	ICGC	AVSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.712
p.S213Y	DO41020	UCEC	ICGC	AVSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.712
p.R335G	TCGA-AA-A02R	COAD	TCGA	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation altering degron motif	0.7568
p.L334S	TCGA-AP-A054	UCEC	TCGA	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation altering degron motif	0.6556
p.L334S	DO222755	COCA	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation altering degron motif	0.6556
p.L334S	DO42256	UCEC	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation altering degron motif	0.6556
p.S54R	TCGA-B8-5162	KIRC	TCGA	DYR	CBL_MET	57:59	Mutation blocking phosphorylation signal	0.6944
p.S54R	DO17197	KIRC	ICGC	DYR	CBL_MET	57:59	Mutation blocking phosphorylation signal	0.6944
p.I341L	TCGA-BH-A0BV	BRCA	TCGA	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation altering degron motif	0.6063
p.G64V	TCGA-C5-A2LT	CESC	TCGA	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.1944
p.G64V	DO49880	CESC	ICGC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.1944
p.F332Y	TCGA-CG-5726	STAD	TCGA	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation rewiring degron network	0.2778
p.F332Y	DO38483	STAD	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation rewiring degron network	0.2778
p.S48T	TCGA-CN-A63W	HNSC	TCGA	DYR	CBL_MET	57:59	Mutation blocking phosphorylation signal	0.5278
p.E63K	TCGA-CR-6473	HNSC	TCGA	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.2222
p.E63K	TCGA-EO-A3B0	UCEC	TCGA	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.2222
p.E63K	DO14228	HNSC	ICGC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.2222
p.E63K	DO219773	UCEC	ICGC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.2222
p.S329C	TCGA-DD-AACI	LIHC	TCGA	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation blocking phosphorylation signal	0.6389
p.S329C	DO52205	LIHC	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation blocking phosphorylation signal	0.6389
p.D60N	TCGA-HF-7132	STAD	TCGA	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.3056
p.D60N	DO38214	STAD	ICGC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.3056
p.V56I	TCGA-N6-A4VE	UCS	TCGA	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.3056
p.S201L	TCGA-NH-A50U	COAD	TCGA	AVSSS	DEG_SPOP_SBC_1	211:215	Mutation blocking phosphorylation signal	0.5
p.Y52F	TCGA-QK-AA3K	HNSC	TCGA	DYR	CBL_MET	57:59	Mutation blocking phosphorylation signal	0.6389
p.Y52F	DO52102	HNSC	ICGC	DYR	CBL_MET	57:59	Mutation blocking phosphorylation signal	0.6389
p.P324A	TCGA-ZF-A9R7	BLCA	TCGA	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation rewiring degron network	0.0556
p.P324A	DO219064	BLCA	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation rewiring degron network	0.0556
p.I348L	DO1295	BRCA	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation rewiring degron network	0.1667
p.S208L	DO51728	COAD	ICGC	AVSSS	DEG_SPOP_SBC_1	211:215	Mutation blocking phosphorylation signal	0.6944
p.T348M	DO228935	COCA	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation rewiring degron network	0.1667
p.T348M	SIDM00254	Neuroblastoma	GDSC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation rewiring degron network	0.1667
p.T348M	NB5	autonomic ganglia	COSMIC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation rewiring degron network	0.1667
p.Q341P	DO229010	COCA	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation altering degron motif	0.7035
p.Q341P	DO229013	COCA	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation altering degron motif	0.7035
p.Q341P	DO229016	COCA	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation altering degron motif	0.7035
p.Q341P	DO229003	COCA	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation altering degron motif	0.7035
p.Q341P	DO229005	COCA	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation altering degron motif	0.7035
p.P333L	DO229005	COCA	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation rewiring degron network	0.3056
p.D328N	DO234387	ESAD	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation blocking ubiquitination signal	0.6111
p.A329T	DO222777	ESCA	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation blocking phosphorylation signal	0.6389
p.R65H	DO233944	GACA	ICGC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.1667
p.R65H	SIDM00447	B-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.1667
p.R65H	ACH-000960	Leukemia	CCLE	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.1667
p.R65H	REH	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.1667
p.S55T	DO49031	HNSC	ICGC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.2778
p.V342A	DO18402	KIRC	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation altering degron motif	0.6936
p.G216C	DO228986	LICA	ICGC	AVSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.3056
p.G216C	DO229045	LICA	ICGC	AVSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.3056
p.K216R	DO23512	LIRI	ICGC	AVSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.3056
p.R351Q	DO51497	PACA	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation rewiring degron network	0.0833
p.E328K	DO224745	PACA	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation blocking ubiquitination signal	0.6111
p.G345E	SIDM00377	Other Sarcomas	GDSC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation rewiring degron network	0.25
p.G345E	SKN	soft tissue	COSMIC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation rewiring degron network	0.25
p.Q346R	SIDM00377	Other Sarcomas	GDSC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation rewiring degron network	0.2222
p.Q346R	SKN	soft tissue	COSMIC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation rewiring degron network	0.2222
p.S329P	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation blocking phosphorylation signal	0.6389
p.S329P	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation blocking phosphorylation signal	0.6389
p.S49C	ACH-000602	Leukemia	CCLE	DYR	CBL_MET	57:59	Mutation blocking phosphorylation signal	0.5556
p.Q65L	ACH-000926	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.1667
p.Q65L	HT55	large intestine	COSMIC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.1667
p.S52N	ACH-000986	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	57:59	Mutation blocking phosphorylation signal	0.6389
p.S52N	HT-115	large intestine	COSMIC	DYR	CBL_MET	57:59	Mutation blocking phosphorylation signal	0.6389
p.S209P	ACH-001127	Leukemia	CCLE	AVSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.2778
p.S209P	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	AVSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.2778
p.G225E	ACH-001655	Endometrial/Uterine Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.0556
p.G225E	SKN	soft tissue	COSMIC	AVSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.0556
p.P333S	ACH-001970	Metastasis	CCLE	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation rewiring degron network	0.3056
p.R325W	HuH-7	liver	COSMIC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation blocking phosphorylation signal	0.5278
p.R65W	NCI-H630	large intestine	COSMIC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.1667
p.R324Q	SNU-1040	large intestine	COSMIC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation rewiring degron network	0.0556
p.G331R	NK-92MI	haematopoietic and lymphoid tissue	COSMIC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation rewiring degron network	0.25
p.K55T	HT-115	large intestine	COSMIC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.2778
p.Y207H	MFE-319	endometrium	COSMIC	AVSSS	DEG_SPOP_SBC_1	211:215	Mutation blocking phosphorylation signal	0.6667
p.E64Q	NCI-H1993	lung	COSMIC	DYR	CBL_MET	57:59	Mutation rewiring degron network	0.1944
p.E201K	CP67-MEL	skin	COSMIC	AVSSS	DEG_SPOP_SBC_1	211:215	Mutation blocking phosphorylation signal	0.5
p.S336P	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation altering degron motif	0.6752
p.R344W	HuH-7	liver	COSMIC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation rewiring degron network	0.2778
p.V49D	NCI-H508	large intestine	COSMIC	DYR	CBL_MET	57:59	Mutation blocking phosphorylation signal	0.5556
p.R351W	HuH-7	liver	COSMIC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation rewiring degron network	0.0833
p.S347P	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	LRQNLHEIE	DEG_APCC_DBOX_1	334:342	Mutation rewiring degron network	0.1944
p.E208K	CP67-MEL	skin	COSMIC	AVSSS	DEG_SPOP_SBC_1	211:215	Mutation blocking phosphorylation signal	0.6944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPHLN1

UniProt ID: Q8NEY8

Entrez ID: 51535

Protein name: Periphilin-1 (CDC7 expression repressor) (CR) (Gastric cancer antigen Ga50)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPHLN1 in