DegronMD

Uniprot ID: Q8NEY8

Source protein: Periphilin-1

Source gene: PPHLN1

Class: DEG_APCC_DBOX_1

Location: 334:342

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9874

ASA_SCORE: 68.7333

COIL: 0.1337

CONS_SCORE: 0.6178

DSS_SCORE: 0.3719

HELIX: 0.8611

FCONS_SCORE: 1.4411

RIG_SCORE: 0.7706

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R335G	TCGA-AA-A02R	COAD	TCGA	LRQNLHEIE	DEG_APCC_DBOX_1	0.7568
p.L334S	TCGA-AP-A054	UCEC	TCGA	LRQNLHEIE	DEG_APCC_DBOX_1	0.6556
p.L334S	DO222755	COCA	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	0.6556
p.L334S	DO42256	UCEC	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	0.6556
p.I341L	TCGA-BH-A0BV	BRCA	TCGA	LRQNLHEIE	DEG_APCC_DBOX_1	0.6063
p.F332Y	TCGA-CG-5726	STAD	TCGA	LRQNLHEIE	DEG_APCC_DBOX_1	0.2778
p.F332Y	DO38483	STAD	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	0.2778
p.S329C	TCGA-DD-AACI	LIHC	TCGA	LRQNLHEIE	DEG_APCC_DBOX_1	0.6389
p.S329C	DO52205	LIHC	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	0.6389
p.P324A	TCGA-ZF-A9R7	BLCA	TCGA	LRQNLHEIE	DEG_APCC_DBOX_1	0.0556
p.P324A	DO219064	BLCA	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	0.0556
p.I348L	DO1295	BRCA	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	0.1667
p.T348M	DO228935	COCA	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	0.1667
p.T348M	SIDM00254	Neuroblastoma	GDSC	LRQNLHEIE	DEG_APCC_DBOX_1	0.1667
p.T348M	NB5	autonomic_ganglia	COSMIC	LRQNLHEIE	DEG_APCC_DBOX_1	0.1667
p.Q341P	DO229010	COCA	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	0.7035
p.Q341P	DO229013	COCA	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	0.7035
p.Q341P	DO229016	COCA	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	0.7035
p.Q341P	DO229003	COCA	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	0.7035
p.Q341P	DO229005	COCA	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	0.7035
p.P333L	DO229005	COCA	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	0.3056
p.D328N	DO234387	ESAD	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	0.6111
p.A329T	DO222777	ESCA	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	0.6389
p.V342A	DO18402	KIRC	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	0.6936
p.R351Q	DO51497	PACA	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	0.0833
p.E328K	DO224745	PACA	ICGC	LRQNLHEIE	DEG_APCC_DBOX_1	0.6111
p.G345E	SIDM00377	Other Sarcomas	GDSC	LRQNLHEIE	DEG_APCC_DBOX_1	0.25
p.G345E	SKN	soft_tissue	COSMIC	LRQNLHEIE	DEG_APCC_DBOX_1	0.25
p.Q346R	SIDM00377	Other Sarcomas	GDSC	LRQNLHEIE	DEG_APCC_DBOX_1	0.2222
p.Q346R	SKN	soft_tissue	COSMIC	LRQNLHEIE	DEG_APCC_DBOX_1	0.2222
p.S329P	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LRQNLHEIE	DEG_APCC_DBOX_1	0.6389
p.S329P	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LRQNLHEIE	DEG_APCC_DBOX_1	0.6389
p.P333S	ACH-001970	Metastasis	CCLE	LRQNLHEIE	DEG_APCC_DBOX_1	0.3056
p.R325W	HuH-7	liver	COSMIC	LRQNLHEIE	DEG_APCC_DBOX_1	0.5278
p.R324Q	SNU-1040	large_intestine	COSMIC	LRQNLHEIE	DEG_APCC_DBOX_1	0.0556
p.G331R	NK-92MI	haematopoietic_and_lymphoid_tissue	COSMIC	LRQNLHEIE	DEG_APCC_DBOX_1	0.25
p.S336P	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LRQNLHEIE	DEG_APCC_DBOX_1	0.6752
p.R344W	HuH-7	liver	COSMIC	LRQNLHEIE	DEG_APCC_DBOX_1	0.2778
p.R351W	HuH-7	liver	COSMIC	LRQNLHEIE	DEG_APCC_DBOX_1	0.0833
p.S347P	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LRQNLHEIE	DEG_APCC_DBOX_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRQNLHEIE

Degron related mutations and impact score

Drug responses associated with PPHLN1 mutations

All proteins holding degron of LRQNLHEIE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEY8	Periphilin-1	DEG_APCC_DBOX_1	334:342	LRQNLHEIE	APC,CDC20,FZR1	0.9874	More...