DegronMD - Q8NDX1(PSD4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L7I	TCGA-04-1516	OV	TCGA	DYR	CBL_MET	4:6	Mutation rewiring degron network	0.3056
p.L7I	DO30140	OV	ICGC	DYR	CBL_MET	4:6	Mutation rewiring degron network	0.3056
p.G212V	TCGA-18-3412	LUSC	TCGA	DSGEDSS	DEG_SCF_TRCP1_1	210:216	Mutation altering degron motif	0.7532
p.G212V	TCGA-3M-AB46	STAD	TCGA	DSGEDSS	DEG_SCF_TRCP1_1	210:216	Mutation altering degron motif	0.7532
p.G212V	DO26552	LUSC	ICGC	DSGEDSS	DEG_SCF_TRCP1_1	210:216	Mutation altering degron motif	0.7532
p.G212V	DO222326	STAD	ICGC	DSGEDSS	DEG_SCF_TRCP1_1	210:216	Mutation altering degron motif	0.7532
p.E213D	TCGA-55-8094	LUAD	TCGA	DSGEDSS	DEG_SCF_TRCP1_1	210:216	Mutation altering degron motif	0.5647
p.E213D	DO24150	LUAD	ICGC	DSGEDSS	DEG_SCF_TRCP1_1	210:216	Mutation altering degron motif	0.5647
p.E213Q	TCGA-57-1992	OV	TCGA	DSGEDSS	DEG_SCF_TRCP1_1	210:216	Mutation altering degron motif	0.5633
p.E213Q	DO32247	OV	ICGC	DSGEDSS	DEG_SCF_TRCP1_1	210:216	Mutation altering degron motif	0.5633
p.M14V	TCGA-AA-3713	COAD	TCGA	DYR	CBL_MET	4:6	Mutation rewiring degron network	0.1111
p.M14V	DO8400	COAD	ICGC	DYR	CBL_MET	4:6	Mutation rewiring degron network	0.1111
p.D9N	TCGA-D9-A6EC	SKCM	TCGA	DYR	CBL_MET	4:6	Mutation rewiring degron network	0.25
p.D9N	DO50291	SKCM	ICGC	DYR	CBL_MET	4:6	Mutation rewiring degron network	0.25
p.P206S	TCGA-DD-AAC9	LIHC	TCGA	DSGEDSS	DEG_SCF_TRCP1_1	210:216	Mutation rewiring degron network	0.2222
p.P206S	DO52194	LIHC	ICGC	DSGEDSS	DEG_SCF_TRCP1_1	210:216	Mutation rewiring degron network	0.2222
p.E209K	TCGA-EB-A3XD	SKCM	TCGA	DSGEDSS	DEG_SCF_TRCP1_1	210:216	Mutation rewiring degron network	0.3056
p.E209K	DO37871	SKCM	ICGC	DSGEDSS	DEG_SCF_TRCP1_1	210:216	Mutation rewiring degron network	0.3056
p.E213K	TCGA-EB-A431	SKCM	TCGA	DSGEDSS	DEG_SCF_TRCP1_1	210:216	Mutation altering degron motif	0.591
p.E213K	TCGA-EE-A2MR	SKCM	TCGA	DSGEDSS	DEG_SCF_TRCP1_1	210:216	Mutation altering degron motif	0.591
p.E213K	DO37671	SKCM	ICGC	DSGEDSS	DEG_SCF_TRCP1_1	210:216	Mutation altering degron motif	0.591
p.E213K	DO37819	SKCM	ICGC	DSGEDSS	DEG_SCF_TRCP1_1	210:216	Mutation altering degron motif	0.591
p.E213K	ACH-001554	Eye Cancer	CCLE	DSGEDSS	DEG_SCF_TRCP1_1	210:216	Mutation altering degron motif	0.591
p.E15K	TCGA-EE-A2MD	SKCM	TCGA	DYR	CBL_MET	4:6	Mutation rewiring degron network	0.0833
p.E15K	DO222434	MELA	ICGC	DYR	CBL_MET	4:6	Mutation rewiring degron network	0.0833
p.E15K	DO37851	SKCM	ICGC	DYR	CBL_MET	4:6	Mutation rewiring degron network	0.0833
p.P206H	TCGA-G4-6588	COAD	TCGA	DSGEDSS	DEG_SCF_TRCP1_1	210:216	Mutation rewiring degron network	0.2222
p.P206H	DO10140	COAD	ICGC	DSGEDSS	DEG_SCF_TRCP1_1	210:216	Mutation rewiring degron network	0.2222
p.E217Q	DO234197	ESAD	ICGC	DSGEDSS	DEG_SCF_TRCP1_1	210:216	Mutation rewiring degron network	0.3056
p.D4Y	DO228985	LICA	ICGC	DYR	CBL_MET	4:6	Mutation altering degron motif	0.7325
p.S204I	DO229018	LICA	ICGC	DSGEDSS	DEG_SCF_TRCP1_1	210:216	Mutation rewiring degron network	0.1667
p.W225L	DO229035	LICA	ICGC	DSGEDSS	DEG_SCF_TRCP1_1	210:216	Mutation rewiring degron network	0.0833
p.E217K	DO222420	MELA	ICGC	DSGEDSS	DEG_SCF_TRCP1_1	210:216	Mutation rewiring degron network	0.3056
p.G222A	DO233297	NACA	ICGC	DSGEDSS	DEG_SCF_TRCP1_1	210:216	Mutation rewiring degron network	0.1667
p.G3S	DO218874	SKCA	ICGC	DYR	CBL_MET	4:6	Mutation rewiring degron network	0.3056
p.S211A	SIDM01081	Oral Cavity Carcinoma	GDSC	DSGEDSS	DEG_SCF_TRCP1_1	210:216	Mutation altering degron motif	0.7588
p.E219Q	ACH-000836	Head and Neck Cancer	CCLE	DSGEDSS	DEG_SCF_TRCP1_1	210:216	Mutation rewiring degron network	0.25
p.E221D	ACH-000941	Endometrial/Uterine Cancer	CCLE	DSGEDSS	DEG_SCF_TRCP1_1	210:216	Mutation rewiring degron network	0.1944
p.G220E	ACH-001232	Brain Cancer	CCLE	DSGEDSS	DEG_SCF_TRCP1_1	210:216	Mutation rewiring degron network	0.2222

Kaplan plot for PSD4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PSD4

UniProt ID: Q8NDX1

Entrez ID: 23550

Protein name: PH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PSD4 in