DegronMD

Uniprot ID: Q8NDX1

Source protein: PH and SEC7 domain-containing protein 4

Source gene: PSD4

Class: DEG_SCF_TRCP1_1

Location: 210:216

E3 ligase: BTRC

DEGRON score: 0.9908

ASA_SCORE: 81.0286

COIL: 0.9236

CONS_SCORE: 0.3454

DSS_SCORE: 0.9389

HELIX: 0.0484

FCONS_SCORE: 1.1197

RIG_SCORE: 0.5195

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G212V	TCGA-18-3412	LUSC	TCGA	DSGEDSS	DEG_SCF_TRCP1_1	0.7532
p.G212V	TCGA-3M-AB46	STAD	TCGA	DSGEDSS	DEG_SCF_TRCP1_1	0.7532
p.G212V	DO26552	LUSC	ICGC	DSGEDSS	DEG_SCF_TRCP1_1	0.7532
p.G212V	DO222326	STAD	ICGC	DSGEDSS	DEG_SCF_TRCP1_1	0.7532
p.E213D	TCGA-55-8094	LUAD	TCGA	DSGEDSS	DEG_SCF_TRCP1_1	0.5647
p.E213D	DO24150	LUAD	ICGC	DSGEDSS	DEG_SCF_TRCP1_1	0.5647
p.E213Q	TCGA-57-1992	OV	TCGA	DSGEDSS	DEG_SCF_TRCP1_1	0.5633
p.E213Q	DO32247	OV	ICGC	DSGEDSS	DEG_SCF_TRCP1_1	0.5633
p.P206S	TCGA-DD-AAC9	LIHC	TCGA	DSGEDSS	DEG_SCF_TRCP1_1	0.2222
p.P206S	DO52194	LIHC	ICGC	DSGEDSS	DEG_SCF_TRCP1_1	0.2222
p.E209K	TCGA-EB-A3XD	SKCM	TCGA	DSGEDSS	DEG_SCF_TRCP1_1	0.3056
p.E209K	DO37871	SKCM	ICGC	DSGEDSS	DEG_SCF_TRCP1_1	0.3056
p.E213K	TCGA-EB-A431	SKCM	TCGA	DSGEDSS	DEG_SCF_TRCP1_1	0.591
p.E213K	TCGA-EE-A2MR	SKCM	TCGA	DSGEDSS	DEG_SCF_TRCP1_1	0.591
p.E213K	DO37671	SKCM	ICGC	DSGEDSS	DEG_SCF_TRCP1_1	0.591
p.E213K	DO37819	SKCM	ICGC	DSGEDSS	DEG_SCF_TRCP1_1	0.591
p.E213K	ACH-001554	Eye Cancer	CCLE	DSGEDSS	DEG_SCF_TRCP1_1	0.591
p.P206H	TCGA-G4-6588	COAD	TCGA	DSGEDSS	DEG_SCF_TRCP1_1	0.2222
p.P206H	DO10140	COAD	ICGC	DSGEDSS	DEG_SCF_TRCP1_1	0.2222
p.E217Q	DO234197	ESAD	ICGC	DSGEDSS	DEG_SCF_TRCP1_1	0.3056
p.S204I	DO229018	LICA	ICGC	DSGEDSS	DEG_SCF_TRCP1_1	0.1667
p.W225L	DO229035	LICA	ICGC	DSGEDSS	DEG_SCF_TRCP1_1	0.0833
p.E217K	DO222420	MELA	ICGC	DSGEDSS	DEG_SCF_TRCP1_1	0.3056
p.G222A	DO233297	NACA	ICGC	DSGEDSS	DEG_SCF_TRCP1_1	0.1667
p.S211A	SIDM01081	Oral Cavity Carcinoma	GDSC	DSGEDSS	DEG_SCF_TRCP1_1	0.7588
p.E219Q	ACH-000836	Head and Neck Cancer	CCLE	DSGEDSS	DEG_SCF_TRCP1_1	0.25
p.E221D	ACH-000941	Endometrial/Uterine Cancer	CCLE	DSGEDSS	DEG_SCF_TRCP1_1	0.1944
p.G220E	ACH-001232	Brain Cancer	CCLE	DSGEDSS	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NDX1	PH and SEC7 domain-containing protein 4	DEG_SCF_TRCP1_1	210:216	DSGEDSS	BTRC	0.9908	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGEDSS

Degron related mutations and impact score

Drug responses associated with PSD4 mutations

All proteins holding degron of DSGEDSS