DegronMD - Q9P2B4(CTTNBP2NL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P341T	TCGA-05-5423	LUAD	TCGA	PATPAYS	DEG_SCF_FBW7_1	338:344	Mutation altering degron motif	0.7031
p.P341T	DO26132	LUAD	ICGC	PATPAYS	DEG_SCF_FBW7_1	338:344	Mutation altering degron motif	0.7031
p.A419T	TCGA-18-3417	LUSC	TCGA	PLSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.0556
p.A419T	DO26584	LUSC	ICGC	PLSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.0556
p.P598Q	TCGA-2W-A8YY	CESC	TCGA	PGLTPSPS	DEG_SCF_FBW7_1	587:594	Mutation rewiring degron network	0.2222
p.P598Q	DO223732	CESC	ICGC	PGLTPSPS	DEG_SCF_FBW7_1	587:594	Mutation rewiring degron network	0.2222
p.P401S	TCGA-AJ-A3BH	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.2222
p.P401S	DO41638	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.2222
p.H603Y	TCGA-AN-A0XW	BRCA	TCGA	PGLTPSPS	DEG_SCF_FBW7_1	587:594	Mutation rewiring degron network	0.0833
p.H603Y	DO1873	BRCA	ICGC	PGLTPSPS	DEG_SCF_FBW7_1	587:594	Mutation rewiring degron network	0.0833
p.A419S	TCGA-AP-A054	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.0556
p.A419S	DO229027	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.0556
p.A419S	DO42256	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.0556
p.P336S	TCGA-BG-A0LX	UCEC	TCGA	PATPAYS	DEG_SCF_FBW7_1	338:344	Mutation rewiring degron network	0.2778
p.P336S	DO41919	UCEC	ICGC	PATPAYS	DEG_SCF_FBW7_1	338:344	Mutation rewiring degron network	0.2778
p.S592Y	TCGA-BG-A0M4	UCEC	TCGA	PGLTPSPS	DEG_SCF_FBW7_1	587:594	Mutation altering degron motif	0.712
p.S592Y	DO41686	UCEC	ICGC	PGLTPSPS	DEG_SCF_FBW7_1	587:594	Mutation altering degron motif	0.712
p.T600I	TCGA-CV-6953	HNSC	TCGA	PGLTPSPS	DEG_SCF_FBW7_1	587:594	Mutation blocking phosphorylation signal	0.6111
p.T600I	DO14278	HNSC	ICGC	PGLTPSPS	DEG_SCF_FBW7_1	587:594	Mutation blocking phosphorylation signal	0.6111
p.P583S	TCGA-CV-7568	HNSC	TCGA	PGLTPSPS	DEG_SCF_FBW7_1	587:594	Mutation rewiring degron network	0.2222
p.P583S	DO14160	HNSC	ICGC	PGLTPSPS	DEG_SCF_FBW7_1	587:594	Mutation rewiring degron network	0.2222
p.P583L	TCGA-CV-7568	HNSC	TCGA	PGLTPSPS	DEG_SCF_FBW7_1	587:594	Mutation rewiring degron network	0.2222
p.P583L	DO14160	HNSC	ICGC	PGLTPSPS	DEG_SCF_FBW7_1	587:594	Mutation rewiring degron network	0.2222
p.P593L	TCGA-D3-A1Q6	SKCM	TCGA	PGLTPSPS	DEG_SCF_FBW7_1	587:594	Mutation altering degron motif	0.6471
p.P593L	TCGA-RP-A695	SKCM	TCGA	PGLTPSPS	DEG_SCF_FBW7_1	587:594	Mutation altering degron motif	0.6471
p.P593L	DO37450	SKCM	ICGC	PGLTPSPS	DEG_SCF_FBW7_1	587:594	Mutation altering degron motif	0.6471
p.P593L	DO51270	SKCM	ICGC	PGLTPSPS	DEG_SCF_FBW7_1	587:594	Mutation altering degron motif	0.6471
p.P580L	TCGA-D6-A6EK	HNSC	TCGA	PGLTPSPS	DEG_SCF_FBW7_1	587:594	Mutation rewiring degron network	0.1389
p.P580L	DO52080	HNSC	ICGC	PGLTPSPS	DEG_SCF_FBW7_1	587:594	Mutation rewiring degron network	0.1389
p.N578T	TCGA-DD-AAE7	LIHC	TCGA	PGLTPSPS	DEG_SCF_FBW7_1	587:594	Mutation rewiring degron network	0.0833
p.N578T	DO52262	LIHC	ICGC	PGLTPSPS	DEG_SCF_FBW7_1	587:594	Mutation rewiring degron network	0.0833
p.P584S	TCGA-FR-A726	SKCM	TCGA	PGLTPSPS	DEG_SCF_FBW7_1	587:594	Mutation rewiring degron network	0.25
p.P584S	DO48665	SKCM	ICGC	PGLTPSPS	DEG_SCF_FBW7_1	587:594	Mutation rewiring degron network	0.25
p.P528L	TCGA-GN-A266	SKCM	TCGA	DYR	CBL_MET	532:534	Mutation rewiring degron network	0.2222
p.P528L	DO37432	SKCM	ICGC	DYR	CBL_MET	532:534	Mutation rewiring degron network	0.2222
p.Y345C	TCGA-L5-A43J	ESCA	TCGA	PATPAYS	DEG_SCF_FBW7_1	338:344	Mutation rewiring degron network	0.3056
p.S594F	DO52639	BOCA	ICGC	PGLTPSPS	DEG_SCF_FBW7_1	587:594	Mutation altering degron motif	0.9093
p.P593S	DO52639	BOCA	ICGC	PGLTPSPS	DEG_SCF_FBW7_1	587:594	Mutation altering degron motif	0.5641
p.G334W	DO228986	LICA	ICGC	PATPAYS	DEG_SCF_FBW7_1	338:344	Mutation rewiring degron network	0.2222
p.P405S	DO220906	MELA	ICGC	PLSSS	DEG_SPOP_SBC_1	405:409	Mutation altering degron motif	0.6752
p.H351Q	SIDM00215	Colorectal Carcinoma	GDSC	PATPAYS	DEG_SCF_FBW7_1	338:344	Mutation rewiring degron network	0.1389
p.T348P	LIM1215	large intestine	COSMIC	PATPAYS	DEG_SCF_FBW7_1	338:344	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CTTNBP2NL

UniProt ID: Q9P2B4

Entrez ID: 55917

Protein name: CTTNBP2 N-terminal-like protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CTTNBP2NL in