DegronMD

Uniprot ID: Q9P2B4

Source protein: CTTNBP2 N-terminal-like protein

Source gene: CTTNBP2NL

Class: DEG_SCF_FBW7_1

Location: 338:344

E3 ligase: FBXW7

DEGRON score: 0.9818

ASA_SCORE: 75.2143

COIL: 0.8794

CONS_SCORE: 0.4386

DSS_SCORE: 0.5211

HELIX: 0.0619

FCONS_SCORE: 1.1537

RIG_SCORE: 0.6877

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P341T	TCGA-05-5423	LUAD	TCGA	PATPAYS	DEG_SCF_FBW7_1	0.7031
p.P341T	DO26132	LUAD	ICGC	PATPAYS	DEG_SCF_FBW7_1	0.7031
p.P336S	TCGA-BG-A0LX	UCEC	TCGA	PATPAYS	DEG_SCF_FBW7_1	0.2778
p.P336S	DO41919	UCEC	ICGC	PATPAYS	DEG_SCF_FBW7_1	0.2778
p.Y345C	TCGA-L5-A43J	ESCA	TCGA	PATPAYS	DEG_SCF_FBW7_1	0.3056
p.G334W	DO228986	LICA	ICGC	PATPAYS	DEG_SCF_FBW7_1	0.2222
p.H351Q	SIDM00215	Colorectal Carcinoma	GDSC	PATPAYS	DEG_SCF_FBW7_1	0.1389
p.T348P	LIM1215	large_intestine	COSMIC	PATPAYS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2B4	CTTNBP2 N-terminal-like protein	DEG_SCF_FBW7_1	338:344	PATPAYS	FBXW7	0.9818	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons