DegronMD

Uniprot ID: Q9P2B4

Source protein: CTTNBP2 N-terminal-like protein

Source gene: CTTNBP2NL

Class: DEG_SCF_FBW7_1

Location: 587:594

E3 ligase: FBXW7

DEGRON score: 0.9027

ASA_SCORE: 87.65

COIL: 0.9569

CONS_SCORE: 0.4935

DSS_SCORE: 0.7785

HELIX: 0.0131

FCONS_SCORE: 0.9373

RIG_SCORE: 0.5344

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P598Q	TCGA-2W-A8YY	CESC	TCGA	PGLTPSPS	DEG_SCF_FBW7_1	0.2222
p.P598Q	DO223732	CESC	ICGC	PGLTPSPS	DEG_SCF_FBW7_1	0.2222
p.H603Y	TCGA-AN-A0XW	BRCA	TCGA	PGLTPSPS	DEG_SCF_FBW7_1	0.0833
p.H603Y	DO1873	BRCA	ICGC	PGLTPSPS	DEG_SCF_FBW7_1	0.0833
p.S592Y	TCGA-BG-A0M4	UCEC	TCGA	PGLTPSPS	DEG_SCF_FBW7_1	0.712
p.S592Y	DO41686	UCEC	ICGC	PGLTPSPS	DEG_SCF_FBW7_1	0.712
p.T600I	TCGA-CV-6953	HNSC	TCGA	PGLTPSPS	DEG_SCF_FBW7_1	0.6111
p.T600I	DO14278	HNSC	ICGC	PGLTPSPS	DEG_SCF_FBW7_1	0.6111
p.P583S	TCGA-CV-7568	HNSC	TCGA	PGLTPSPS	DEG_SCF_FBW7_1	0.2222
p.P583S	DO14160	HNSC	ICGC	PGLTPSPS	DEG_SCF_FBW7_1	0.2222
p.P583L	TCGA-CV-7568	HNSC	TCGA	PGLTPSPS	DEG_SCF_FBW7_1	0.2222
p.P583L	DO14160	HNSC	ICGC	PGLTPSPS	DEG_SCF_FBW7_1	0.2222
p.P593L	TCGA-D3-A1Q6	SKCM	TCGA	PGLTPSPS	DEG_SCF_FBW7_1	0.6471
p.P593L	TCGA-RP-A695	SKCM	TCGA	PGLTPSPS	DEG_SCF_FBW7_1	0.6471
p.P593L	DO37450	SKCM	ICGC	PGLTPSPS	DEG_SCF_FBW7_1	0.6471
p.P593L	DO51270	SKCM	ICGC	PGLTPSPS	DEG_SCF_FBW7_1	0.6471
p.P580L	TCGA-D6-A6EK	HNSC	TCGA	PGLTPSPS	DEG_SCF_FBW7_1	0.1389
p.P580L	DO52080	HNSC	ICGC	PGLTPSPS	DEG_SCF_FBW7_1	0.1389
p.N578T	TCGA-DD-AAE7	LIHC	TCGA	PGLTPSPS	DEG_SCF_FBW7_1	0.0833
p.N578T	DO52262	LIHC	ICGC	PGLTPSPS	DEG_SCF_FBW7_1	0.0833
p.P584S	TCGA-FR-A726	SKCM	TCGA	PGLTPSPS	DEG_SCF_FBW7_1	0.25
p.P584S	DO48665	SKCM	ICGC	PGLTPSPS	DEG_SCF_FBW7_1	0.25
p.S594F	DO52639	BOCA	ICGC	PGLTPSPS	DEG_SCF_FBW7_1	0.9093
p.P593S	DO52639	BOCA	ICGC	PGLTPSPS	DEG_SCF_FBW7_1	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2B4	CTTNBP2 N-terminal-like protein	DEG_SCF_FBW7_1	587:594	PGLTPSPS	FBXW7	0.9027	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons