DegronMD - P10515(DLAT)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A302T	TCGA-06-5416	GBM	TCGA	DYR	CBL_MET	305:307	Mutation rewiring degron network	0.25
p.A302T	DO10880	GBM	ICGC	DYR	CBL_MET	305:307	Mutation rewiring degron network	0.25
p.P187R	TCGA-13-0920	OV	TCGA	PAPTPAAT	DEG_SCF_FBW7_1	193:200	Mutation rewiring degron network	0.1667
p.P187R	DO28099	OV	ICGC	PAPTPAAT	DEG_SCF_FBW7_1	193:200	Mutation rewiring degron network	0.1667
p.V34M	TCGA-44-4112	LUAD	TCGA	VPGTPRVT	DEG_SCF_FBW7_1	28:35	Mutation altering degron motif	0.6097
p.V34M	DO233259	GACA	ICGC	VPGTPRVT	DEG_SCF_FBW7_1	28:35	Mutation altering degron motif	0.6097
p.V34M	DO26032	LUAD	ICGC	VPGTPRVT	DEG_SCF_FBW7_1	28:35	Mutation altering degron motif	0.6097
p.P323L	TCGA-49-AARQ	LUAD	TCGA	PPVAAVPPT	DEG_SIAH_1	324:332	Mutation rewiring degron network	0.3056
p.P323L	DO51189	LUAD	ICGC	PPVAAVPPT	DEG_SIAH_1	324:332	Mutation rewiring degron network	0.3056
p.T417A	TCGA-55-6985	LUAD	TCGA	APAAVVPPT	DEG_SIAH_1	400:408	Mutation rewiring degron network	0.0833
p.T417A	DO25659	LUAD	ICGC	APAAVVPPT	DEG_SIAH_1	400:408	Mutation rewiring degron network	0.0833
p.P189T	TCGA-55-8506	LUAD	TCGA	PAPTPAAT	DEG_SCF_FBW7_1	193:200	Mutation rewiring degron network	0.2222
p.P189T	DO45390	LUAD	ICGC	PAPTPAAT	DEG_SCF_FBW7_1	193:200	Mutation rewiring degron network	0.2222
p.P203Q	TCGA-77-7465	LUSC	TCGA	PAPTPAAT	DEG_SCF_FBW7_1	193:200	Mutation rewiring degron network	0.25
p.P203Q	DO27699	LUSC	ICGC	PAPTPAAT	DEG_SCF_FBW7_1	193:200	Mutation rewiring degron network	0.25
p.G409R	TCGA-86-8585	LUAD	TCGA	APAAVVPPT	DEG_SIAH_1	400:408	Mutation rewiring degron network	0.3056
p.G411V	TCGA-A5-A0G1	UCEC	TCGA	APAAVVPPT	DEG_SIAH_1	400:408	Mutation rewiring degron network	0.25
p.S202L	TCGA-A6-6653	COAD	TCGA	PAPTPAAT	DEG_SCF_FBW7_1	193:200	Mutation rewiring degron network	0.2778
p.S202L	TCGA-B5-A3FA	UCEC	TCGA	PAPTPAAT	DEG_SCF_FBW7_1	193:200	Mutation rewiring degron network	0.2778
p.S202L	TCGA-FS-A1ZP	SKCM	TCGA	PAPTPAAT	DEG_SCF_FBW7_1	193:200	Mutation rewiring degron network	0.2778
p.S202L	TCGA-IB-7651	PAAD	TCGA	PAPTPAAT	DEG_SCF_FBW7_1	193:200	Mutation rewiring degron network	0.2778
p.S202L	DO10373	COAD	ICGC	PAPTPAAT	DEG_SCF_FBW7_1	193:200	Mutation rewiring degron network	0.2778
p.S202L	DO46657	PAAD	ICGC	PAPTPAAT	DEG_SCF_FBW7_1	193:200	Mutation rewiring degron network	0.2778
p.S202L	DO37703	SKCM	ICGC	PAPTPAAT	DEG_SCF_FBW7_1	193:200	Mutation rewiring degron network	0.2778
p.S202L	DO52402	UCEC	ICGC	PAPTPAAT	DEG_SCF_FBW7_1	193:200	Mutation rewiring degron network	0.2778
p.A198D	TCGA-AP-A051	UCEC	TCGA	PAPTPAAT	DEG_SCF_FBW7_1	193:200	Mutation altering degron motif	0.6682
p.A198D	DO42673	UCEC	ICGC	PAPTPAAT	DEG_SCF_FBW7_1	193:200	Mutation altering degron motif	0.6682
p.A191V	TCGA-AX-A1C9	UCEC	TCGA	PAPTPAAT	DEG_SCF_FBW7_1	193:200	Mutation rewiring degron network	0.2778
p.A191V	DO43098	UCEC	ICGC	PAPTPAAT	DEG_SCF_FBW7_1	193:200	Mutation rewiring degron network	0.2778
p.A191V	ACH-001844	Bile Duct Cancer	CCLE	PAPTPAAT	DEG_SCF_FBW7_1	193:200	Mutation rewiring degron network	0.2778
p.P401A	TCGA-B0-5104	KIRC	TCGA	APAAVVPPT	DEG_SIAH_1	400:408	Mutation altering degron motif	0.7503
p.P401A	DO16955	KIRC	ICGC	APAAVVPPT	DEG_SIAH_1	400:408	Mutation altering degron motif	0.7503
p.Q26H	TCGA-BG-A0VW	UCEC	TCGA	VPGTPRVT	DEG_SCF_FBW7_1	28:35	Mutation rewiring degron network	0.2778
p.Q26H	DO40843	UCEC	ICGC	VPGTPRVT	DEG_SCF_FBW7_1	28:35	Mutation rewiring degron network	0.2778
p.T408P	TCGA-CN-A49B	HNSC	TCGA	APAAVVPPT	DEG_SIAH_1	400:408	Mutation altering degron motif	0.7031
p.P42T	TCGA-EE-A29E	SKCM	TCGA	VPGTPRVT	DEG_SCF_FBW7_1	28:35	Mutation rewiring degron network	0.1389
p.P42T	DO37831	SKCM	ICGC	VPGTPRVT	DEG_SCF_FBW7_1	28:35	Mutation rewiring degron network	0.1389
p.S391F	TCGA-EE-A29E	SKCM	TCGA	APAAVVPPT	DEG_SIAH_1	400:408	Mutation blocking phosphorylation signal	0.5278
p.P204H	TCGA-EI-6507	READ	TCGA	PAPTPAAT	DEG_SCF_FBW7_1	193:200	Mutation rewiring degron network	0.2222
p.P204H	DO36675	READ	ICGC	PAPTPAAT	DEG_SCF_FBW7_1	193:200	Mutation rewiring degron network	0.2222
p.D390N	TCGA-EO-A22U	UCEC	TCGA	APAAVVPPT	DEG_SIAH_1	400:408	Mutation rewiring degron network	0.0556
p.A328T	TCGA-F5-6814	READ	TCGA	PPVAAVPPT	DEG_SIAH_1	324:332	Mutation altering degron motif	0.6028
p.T23K	TCGA-FD-A5BZ	BLCA	TCGA	VPGTPRVT	DEG_SCF_FBW7_1	28:35	Mutation rewiring degron network	0.1944
p.T23K	DO44052	BLCA	ICGC	VPGTPRVT	DEG_SCF_FBW7_1	28:35	Mutation rewiring degron network	0.1944
p.P40Q	TCGA-FS-A1ZZ	SKCM	TCGA	VPGTPRVT	DEG_SCF_FBW7_1	28:35	Mutation rewiring degron network	0.1944
p.P40Q	DO37412	SKCM	ICGC	VPGTPRVT	DEG_SCF_FBW7_1	28:35	Mutation rewiring degron network	0.1944
p.V415A	TCGA-GF-A6C9	SKCM	TCGA	APAAVVPPT	DEG_SIAH_1	400:408	Mutation rewiring degron network	0.1389
p.H402D	DO1076	BRCA	ICGC	APAAVVPPT	DEG_SIAH_1	400:408	Mutation altering degron motif	0.7688
p.A414T	DO1608	BRCA	ICGC	APAAVVPPT	DEG_SIAH_1	400:408	Mutation rewiring degron network	0.1667
p.A43V	DO229010	COCA	ICGC	VPGTPRVT	DEG_SCF_FBW7_1	28:35	Mutation rewiring degron network	0.1111
p.A43V	DO229013	COCA	ICGC	VPGTPRVT	DEG_SCF_FBW7_1	28:35	Mutation rewiring degron network	0.1111
p.A43V	DO229016	COCA	ICGC	VPGTPRVT	DEG_SCF_FBW7_1	28:35	Mutation rewiring degron network	0.1111
p.A43V	DO229003	COCA	ICGC	VPGTPRVT	DEG_SCF_FBW7_1	28:35	Mutation rewiring degron network	0.1111
p.A43V	DO229005	COCA	ICGC	VPGTPRVT	DEG_SCF_FBW7_1	28:35	Mutation rewiring degron network	0.1111
p.A43V	DO229038	LICA	ICGC	VPGTPRVT	DEG_SCF_FBW7_1	28:35	Mutation rewiring degron network	0.1111
p.A43V	DO230927	LUSC	ICGC	VPGTPRVT	DEG_SCF_FBW7_1	28:35	Mutation rewiring degron network	0.1111
p.V318A	DO229010	COCA	ICGC	PPVAAVPPT	DEG_SIAH_1	324:332	Mutation rewiring degron network	0.1667
p.V318A	DO229013	COCA	ICGC	PPVAAVPPT	DEG_SIAH_1	324:332	Mutation rewiring degron network	0.1667
p.V318A	DO229016	COCA	ICGC	PPVAAVPPT	DEG_SIAH_1	324:332	Mutation rewiring degron network	0.1667
p.V318A	DO229003	COCA	ICGC	PPVAAVPPT	DEG_SIAH_1	324:332	Mutation rewiring degron network	0.1667
p.V318A	DO229005	COCA	ICGC	PPVAAVPPT	DEG_SIAH_1	324:332	Mutation rewiring degron network	0.1667
p.V318A	DO230659	LAML	ICGC	PPVAAVPPT	DEG_SIAH_1	324:332	Mutation rewiring degron network	0.1667
p.V318A	DO231140	LAML	ICGC	PPVAAVPPT	DEG_SIAH_1	324:332	Mutation rewiring degron network	0.1667
p.T303P	DO44428	HNSC	ICGC	DYR	CBL_MET	305:307	Mutation rewiring degron network	0.2778
p.A208T	DO228809	LICA	ICGC	PAPTPAAT	DEG_SCF_FBW7_1	193:200	Mutation rewiring degron network	0.1111
p.P203S	DO228918	LICA	ICGC	PAPTPAAT	DEG_SCF_FBW7_1	193:200	Mutation rewiring degron network	0.25
p.A208S	DO228948	LICA	ICGC	PAPTPAAT	DEG_SCF_FBW7_1	193:200	Mutation rewiring degron network	0.1111
p.D395Y	DO228952	LICA	ICGC	APAAVVPPT	DEG_SIAH_1	400:408	Mutation rewiring degron network	0.1944
p.A198S	DO229018	LICA	ICGC	PAPTPAAT	DEG_SCF_FBW7_1	193:200	Mutation altering degron motif	0.6477
p.A210S	DO229018	LICA	ICGC	PAPTPAAT	DEG_SCF_FBW7_1	193:200	Mutation rewiring degron network	0.0556
p.F315Y	DO229027	LICA	ICGC	PPVAAVPPT	DEG_SIAH_1	324:332	Mutation substituting flanking lysine	0.1944
p.F315Y	DO229027	LICA	ICGC	DYR	CBL_MET	305:307	Mutation substituting flanking lysine	0.2222
p.R325L	DO229027	LICA	ICGC	PPVAAVPPT	DEG_SIAH_1	324:332	Mutation altering degron motif	0.8428
p.V28L	DO229038	LICA	ICGC	VPGTPRVT	DEG_SCF_FBW7_1	28:35	Mutation altering degron motif	0.5654
p.G39V	DO229037	LICA	ICGC	VPGTPRVT	DEG_SCF_FBW7_1	28:35	Mutation rewiring degron network	0.2222
p.G304V	DO229045	LICA	ICGC	DYR	CBL_MET	305:307	Mutation rewiring degron network	0.3056
p.G304R	DO24850	LUAD	ICGC	DYR	CBL_MET	305:307	Mutation rewiring degron network	0.3056
p.S183F	DO220903	MELA	ICGC	PAPTPAAT	DEG_SCF_FBW7_1	193:200	Mutation rewiring degron network	0.0556
p.P311S	DO27943	ORCA	ICGC	DYR	CBL_MET	305:307	Mutation rewiring degron network	0.2222
p.S411N	DO46657	PAAD	ICGC	APAAVVPPT	DEG_SIAH_1	400:408	Mutation rewiring degron network	0.25
p.V310A	DO51254	SKCM	ICGC	DYR	CBL_MET	305:307	Mutation rewiring degron network	0.25
p.G306V	DO42472	UCEC	ICGC	DYR	CBL_MET	305:307	Mutation altering degron motif	0.7532
p.P410R	SIDM00216	Colorectal Carcinoma	GDSC	APAAVVPPT	DEG_SIAH_1	400:408	Mutation rewiring degron network	0.2778
p.P410R	SIDM01582	Gastric Carcinoma	GDSC	APAAVVPPT	DEG_SIAH_1	400:408	Mutation rewiring degron network	0.2778
p.P316S	SIDM00984	Other Blood Cancers	GDSC	PPVAAVPPT	DEG_SIAH_1	324:332	Mutation rewiring degron network	0.1111
p.P316S	SIDM00984	Other Blood Cancers	GDSC	DYR	CBL_MET	305:307	Mutation rewiring degron network	0.0833
p.P316S	SIDM01155	Glioma	GDSC	PPVAAVPPT	DEG_SIAH_1	324:332	Mutation rewiring degron network	0.1111
p.P316S	SIDM01155	Glioma	GDSC	DYR	CBL_MET	305:307	Mutation rewiring degron network	0.0833
p.P316S	BONNA-12	haematopoietic and lymphoid tissue	COSMIC	PPVAAVPPT	DEG_SIAH_1	324:332	Mutation rewiring degron network	0.1111
p.P316S	BONNA-12	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	305:307	Mutation rewiring degron network	0.0833
p.P316S	SW1088	central nervous system	COSMIC	PPVAAVPPT	DEG_SIAH_1	324:332	Mutation rewiring degron network	0.1111
p.P316S	SW1088	central nervous system	COSMIC	DYR	CBL_MET	305:307	Mutation rewiring degron network	0.0833
p.S301L	SIDM00447	B-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	305:307	Mutation rewiring degron network	0.2222
p.S301L	ACH-000960	Leukemia	CCLE	DYR	CBL_MET	305:307	Mutation rewiring degron network	0.2222
p.S301L	REH	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	305:307	Mutation rewiring degron network	0.2222
p.E310K	SIDM00971	Breast Carcinoma	GDSC	DYR	CBL_MET	305:307	Mutation rewiring degron network	0.25
p.E310K	SIDM00254	Neuroblastoma	GDSC	DYR	CBL_MET	305:307	Mutation rewiring degron network	0.25
p.E310K	SIDM00844	Burkitt's Lymphoma	GDSC	DYR	CBL_MET	305:307	Mutation rewiring degron network	0.25
p.E310K	SIDM00721	Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	305:307	Mutation rewiring degron network	0.25
p.E310K	SIDM01664	Prostate Carcinoma	GDSC	DYR	CBL_MET	305:307	Mutation rewiring degron network	0.25
p.A337T	SIDM00511	Small Cell Lung Carcinoma	GDSC	PPVAAVPPT	DEG_SIAH_1	324:332	Mutation rewiring degron network	0.1944
p.A337T	COR-L279	lung	COSMIC	PPVAAVPPT	DEG_SIAH_1	324:332	Mutation rewiring degron network	0.1944
p.P331A	SIDM00549	B-Lymphoblastic Leukemia	GDSC	PPVAAVPPT	DEG_SIAH_1	324:332	Mutation altering degron motif	0.7503
p.P331A	LC4-1	haematopoietic and lymphoid tissue	COSMIC	PPVAAVPPT	DEG_SIAH_1	324:332	Mutation altering degron motif	0.7503
p.P189Q	SIDM01170	Ovarian Carcinoma	GDSC	PAPTPAAT	DEG_SCF_FBW7_1	193:200	Mutation rewiring degron network	0.2222
p.P189Q	ACH-000048	Ovarian Cancer	CCLE	PAPTPAAT	DEG_SCF_FBW7_1	193:200	Mutation rewiring degron network	0.2222
p.P189Q	TOV-112D	ovary	COSMIC	PAPTPAAT	DEG_SCF_FBW7_1	193:200	Mutation rewiring degron network	0.2222
p.P305R	ACH-000507	Gastric Cancer	CCLE	DYR	CBL_MET	305:307	Mutation altering degron motif	0.7512
p.P305R	ACH-000989	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	305:307	Mutation altering degron motif	0.7512
p.H402Y	ACH-001358	Breast Cancer	CCLE	APAAVVPPT	DEG_SIAH_1	400:408	Mutation altering degron motif	0.7229
p.H402Y	MDA-MB-330	breast	COSMIC	APAAVVPPT	DEG_SIAH_1	400:408	Mutation altering degron motif	0.7229

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DLAT

UniProt ID: P10515

Entrez ID: 1737

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DLAT in