DegronMD

Uniprot ID: P10515

Source protein: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

Source gene: DLAT

Class: DEG_SIAH_1

Location: 324:332

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9967

ASA_SCORE: 96.8

COIL: 0.9722

CONS_SCORE: 0.3631

DSS_SCORE: 0.6816

HELIX: 0.0133

FCONS_SCORE: 1.1924

RIG_SCORE: 0.5981

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P323L	TCGA-49-AARQ	LUAD	TCGA	PPVAAVPPT	DEG_SIAH_1	0.3056
p.P323L	DO51189	LUAD	ICGC	PPVAAVPPT	DEG_SIAH_1	0.3056
p.A328T	TCGA-F5-6814	READ	TCGA	PPVAAVPPT	DEG_SIAH_1	0.6028
p.V318A	DO229010	COCA	ICGC	PPVAAVPPT	DEG_SIAH_1	0.1667
p.V318A	DO229013	COCA	ICGC	PPVAAVPPT	DEG_SIAH_1	0.1667
p.V318A	DO229016	COCA	ICGC	PPVAAVPPT	DEG_SIAH_1	0.1667
p.V318A	DO229003	COCA	ICGC	PPVAAVPPT	DEG_SIAH_1	0.1667
p.V318A	DO229005	COCA	ICGC	PPVAAVPPT	DEG_SIAH_1	0.1667
p.V318A	DO230659	LAML	ICGC	PPVAAVPPT	DEG_SIAH_1	0.1667
p.V318A	DO231140	LAML	ICGC	PPVAAVPPT	DEG_SIAH_1	0.1667
p.F315Y	DO229027	LICA	ICGC	PPVAAVPPT	DEG_SIAH_1	0.1944
p.R325L	DO229027	LICA	ICGC	PPVAAVPPT	DEG_SIAH_1	0.8428
p.P316S	SIDM00984	Other Blood Cancers	GDSC	PPVAAVPPT	DEG_SIAH_1	0.1111
p.P316S	SIDM01155	Glioma	GDSC	PPVAAVPPT	DEG_SIAH_1	0.1111
p.P316S	BONNA-12	haematopoietic_and_lymphoid_tissue	COSMIC	PPVAAVPPT	DEG_SIAH_1	0.1111
p.P316S	SW1088	central_nervous_system	COSMIC	PPVAAVPPT	DEG_SIAH_1	0.1111
p.A337T	SIDM00511	Small Cell Lung Carcinoma	GDSC	PPVAAVPPT	DEG_SIAH_1	0.1944
p.A337T	COR-L279	lung	COSMIC	PPVAAVPPT	DEG_SIAH_1	0.1944
p.P331A	SIDM00549	B-Lymphoblastic Leukemia	GDSC	PPVAAVPPT	DEG_SIAH_1	0.7503
p.P331A	LC4-1	haematopoietic_and_lymphoid_tissue	COSMIC	PPVAAVPPT	DEG_SIAH_1	0.7503

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10515	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DEG_SIAH_1	324:332	PPVAAVPPT	SIAH1,SIAH2,SIAH3	0.9967	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons