DegronMD

Uniprot ID: P10515

Source protein: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

Source gene: DLAT

Class: DEG_SIAH_1

Location: 400:408

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9744

ASA_SCORE: 89.4222

COIL: 0.9661

CONS_SCORE: 0.3364

DSS_SCORE: 0.4654

HELIX: 0.0136

FCONS_SCORE: 0.9383

RIG_SCORE: 0.6852

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T417A	TCGA-55-6985	LUAD	TCGA	APAAVVPPT	DEG_SIAH_1	0.0833
p.T417A	DO25659	LUAD	ICGC	APAAVVPPT	DEG_SIAH_1	0.0833
p.G409R	TCGA-86-8585	LUAD	TCGA	APAAVVPPT	DEG_SIAH_1	0.3056
p.G411V	TCGA-A5-A0G1	UCEC	TCGA	APAAVVPPT	DEG_SIAH_1	0.25
p.P401A	TCGA-B0-5104	KIRC	TCGA	APAAVVPPT	DEG_SIAH_1	0.7503
p.P401A	DO16955	KIRC	ICGC	APAAVVPPT	DEG_SIAH_1	0.7503
p.T408P	TCGA-CN-A49B	HNSC	TCGA	APAAVVPPT	DEG_SIAH_1	0.7031
p.S391F	TCGA-EE-A29E	SKCM	TCGA	APAAVVPPT	DEG_SIAH_1	0.5278
p.D390N	TCGA-EO-A22U	UCEC	TCGA	APAAVVPPT	DEG_SIAH_1	0.0556
p.V415A	TCGA-GF-A6C9	SKCM	TCGA	APAAVVPPT	DEG_SIAH_1	0.1389
p.H402D	DO1076	BRCA	ICGC	APAAVVPPT	DEG_SIAH_1	0.7688
p.A414T	DO1608	BRCA	ICGC	APAAVVPPT	DEG_SIAH_1	0.1667
p.D395Y	DO228952	LICA	ICGC	APAAVVPPT	DEG_SIAH_1	0.1944
p.S411N	DO46657	PAAD	ICGC	APAAVVPPT	DEG_SIAH_1	0.25
p.P410R	SIDM00216	Colorectal Carcinoma	GDSC	APAAVVPPT	DEG_SIAH_1	0.2778
p.P410R	SIDM01582	Gastric Carcinoma	GDSC	APAAVVPPT	DEG_SIAH_1	0.2778
p.H402Y	ACH-001358	Breast Cancer	CCLE	APAAVVPPT	DEG_SIAH_1	0.7229
p.H402Y	MDA-MB-330	breast	COSMIC	APAAVVPPT	DEG_SIAH_1	0.7229

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10515	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DEG_SIAH_1	400:408	APAAVVPPT	SIAH1,SIAH2,SIAH3	0.9744	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons