DegronMD

Uniprot ID: P10515

Source protein: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

Source gene: DLAT

Class: DEG_SCF_FBW7_1

Location: 193:200

E3 ligase: FBXW7

DEGRON score: 0.993

ASA_SCORE: 70.25

COIL: 0.8661

CONS_SCORE: 0.3778

DSS_SCORE: 0.707

HELIX: 0.0703

FCONS_SCORE: 1.2825

RIG_SCORE: 0.5678

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P187R	TCGA-13-0920	OV	TCGA	PAPTPAAT	DEG_SCF_FBW7_1	0.1667
p.P187R	DO28099	OV	ICGC	PAPTPAAT	DEG_SCF_FBW7_1	0.1667
p.P189T	TCGA-55-8506	LUAD	TCGA	PAPTPAAT	DEG_SCF_FBW7_1	0.2222
p.P189T	DO45390	LUAD	ICGC	PAPTPAAT	DEG_SCF_FBW7_1	0.2222
p.P203Q	TCGA-77-7465	LUSC	TCGA	PAPTPAAT	DEG_SCF_FBW7_1	0.25
p.P203Q	DO27699	LUSC	ICGC	PAPTPAAT	DEG_SCF_FBW7_1	0.25
p.S202L	TCGA-A6-6653	COAD	TCGA	PAPTPAAT	DEG_SCF_FBW7_1	0.2778
p.S202L	TCGA-B5-A3FA	UCEC	TCGA	PAPTPAAT	DEG_SCF_FBW7_1	0.2778
p.S202L	TCGA-FS-A1ZP	SKCM	TCGA	PAPTPAAT	DEG_SCF_FBW7_1	0.2778
p.S202L	TCGA-IB-7651	PAAD	TCGA	PAPTPAAT	DEG_SCF_FBW7_1	0.2778
p.S202L	DO10373	COAD	ICGC	PAPTPAAT	DEG_SCF_FBW7_1	0.2778
p.S202L	DO46657	PAAD	ICGC	PAPTPAAT	DEG_SCF_FBW7_1	0.2778
p.S202L	DO37703	SKCM	ICGC	PAPTPAAT	DEG_SCF_FBW7_1	0.2778
p.S202L	DO52402	UCEC	ICGC	PAPTPAAT	DEG_SCF_FBW7_1	0.2778
p.A198D	TCGA-AP-A051	UCEC	TCGA	PAPTPAAT	DEG_SCF_FBW7_1	0.6682
p.A198D	DO42673	UCEC	ICGC	PAPTPAAT	DEG_SCF_FBW7_1	0.6682
p.A191V	TCGA-AX-A1C9	UCEC	TCGA	PAPTPAAT	DEG_SCF_FBW7_1	0.2778
p.A191V	DO43098	UCEC	ICGC	PAPTPAAT	DEG_SCF_FBW7_1	0.2778
p.A191V	ACH-001844	Bile Duct Cancer	CCLE	PAPTPAAT	DEG_SCF_FBW7_1	0.2778
p.P204H	TCGA-EI-6507	READ	TCGA	PAPTPAAT	DEG_SCF_FBW7_1	0.2222
p.P204H	DO36675	READ	ICGC	PAPTPAAT	DEG_SCF_FBW7_1	0.2222
p.A208T	DO228809	LICA	ICGC	PAPTPAAT	DEG_SCF_FBW7_1	0.1111
p.P203S	DO228918	LICA	ICGC	PAPTPAAT	DEG_SCF_FBW7_1	0.25
p.A208S	DO228948	LICA	ICGC	PAPTPAAT	DEG_SCF_FBW7_1	0.1111
p.A198S	DO229018	LICA	ICGC	PAPTPAAT	DEG_SCF_FBW7_1	0.6477
p.A210S	DO229018	LICA	ICGC	PAPTPAAT	DEG_SCF_FBW7_1	0.0556
p.S183F	DO220903	MELA	ICGC	PAPTPAAT	DEG_SCF_FBW7_1	0.0556
p.P189Q	SIDM01170	Ovarian Carcinoma	GDSC	PAPTPAAT	DEG_SCF_FBW7_1	0.2222
p.P189Q	ACH-000048	Ovarian Cancer	CCLE	PAPTPAAT	DEG_SCF_FBW7_1	0.2222
p.P189Q	TOV-112D	ovary	COSMIC	PAPTPAAT	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PAPTPAAT

Degron related mutations and impact score

Drug responses associated with DLAT mutations

All proteins holding degron of PAPTPAAT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10515	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DEG_SCF_FBW7_1	193:200	PAPTPAAT	FBXW7	0.993	More...