DegronMD

Uniprot ID: P10515

Source protein: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

Source gene: DLAT

Class: DEG_SCF_FBW7_1

Location: 28:35

E3 ligase: FBXW7

DEGRON score: 0.9772

ASA_SCORE: 59.6

COIL: 0.771

CONS_SCORE: 0.2282

DSS_SCORE: 0.545

HELIX: 0.1173

FCONS_SCORE: 1.0827

RIG_SCORE: 0.7002

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V34M	TCGA-44-4112	LUAD	TCGA	VPGTPRVT	DEG_SCF_FBW7_1	0.6097
p.V34M	DO233259	GACA	ICGC	VPGTPRVT	DEG_SCF_FBW7_1	0.6097
p.V34M	DO26032	LUAD	ICGC	VPGTPRVT	DEG_SCF_FBW7_1	0.6097
p.Q26H	TCGA-BG-A0VW	UCEC	TCGA	VPGTPRVT	DEG_SCF_FBW7_1	0.2778
p.Q26H	DO40843	UCEC	ICGC	VPGTPRVT	DEG_SCF_FBW7_1	0.2778
p.P42T	TCGA-EE-A29E	SKCM	TCGA	VPGTPRVT	DEG_SCF_FBW7_1	0.1389
p.P42T	DO37831	SKCM	ICGC	VPGTPRVT	DEG_SCF_FBW7_1	0.1389
p.T23K	TCGA-FD-A5BZ	BLCA	TCGA	VPGTPRVT	DEG_SCF_FBW7_1	0.1944
p.T23K	DO44052	BLCA	ICGC	VPGTPRVT	DEG_SCF_FBW7_1	0.1944
p.P40Q	TCGA-FS-A1ZZ	SKCM	TCGA	VPGTPRVT	DEG_SCF_FBW7_1	0.1944
p.P40Q	DO37412	SKCM	ICGC	VPGTPRVT	DEG_SCF_FBW7_1	0.1944
p.A43V	DO229010	COCA	ICGC	VPGTPRVT	DEG_SCF_FBW7_1	0.1111
p.A43V	DO229013	COCA	ICGC	VPGTPRVT	DEG_SCF_FBW7_1	0.1111
p.A43V	DO229016	COCA	ICGC	VPGTPRVT	DEG_SCF_FBW7_1	0.1111
p.A43V	DO229003	COCA	ICGC	VPGTPRVT	DEG_SCF_FBW7_1	0.1111
p.A43V	DO229005	COCA	ICGC	VPGTPRVT	DEG_SCF_FBW7_1	0.1111
p.A43V	DO229038	LICA	ICGC	VPGTPRVT	DEG_SCF_FBW7_1	0.1111
p.A43V	DO230927	LUSC	ICGC	VPGTPRVT	DEG_SCF_FBW7_1	0.1111
p.V28L	DO229038	LICA	ICGC	VPGTPRVT	DEG_SCF_FBW7_1	0.5654
p.G39V	DO229037	LICA	ICGC	VPGTPRVT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10515	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DEG_SCF_FBW7_1	28:35	VPGTPRVT	FBXW7	0.9772	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons