DegronMD - Q9H6Y2(WDR55)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A325T	TCGA-CK-5916	COAD	TCGA	DYR	CBL_MET	334:336	Mutation rewiring degron network	0.0833
p.A325T	DO8786	COAD	ICGC	DYR	CBL_MET	334:336	Mutation rewiring degron network	0.0833
p.D333A	TCGA-CW-6093	KIRC	TCGA	DYR	CBL_MET	334:336	Mutation rewiring degron network	0.3056
p.D333A	DO16248	KIRC	ICGC	DYR	CBL_MET	334:336	Mutation rewiring degron network	0.3056
p.R337W	TCGA-DC-6160	READ	TCGA	DYR	CBL_MET	334:336	Mutation rewiring degron network	0.3056
p.R337W	TCGA-DF-A2KU	UCEC	TCGA	DYR	CBL_MET	334:336	Mutation rewiring degron network	0.3056
p.R337W	DO36391	READ	ICGC	DYR	CBL_MET	334:336	Mutation rewiring degron network	0.3056
p.R337W	DO223286	UCEC	ICGC	DYR	CBL_MET	334:336	Mutation rewiring degron network	0.3056
p.R338H	TCGA-DI-A0WH	UCEC	TCGA	DYR	CBL_MET	334:336	Mutation rewiring degron network	0.2778
p.R338H	TCGA-DU-6392	LGG	TCGA	DYR	CBL_MET	334:336	Mutation rewiring degron network	0.2778
p.R338H	TCGA-WQ-A9G7	LIHC	TCGA	DYR	CBL_MET	334:336	Mutation rewiring degron network	0.2778
p.R338H	DO22237	LGG	ICGC	DYR	CBL_MET	334:336	Mutation rewiring degron network	0.2778
p.R338H	DO52326	LIHC	ICGC	DYR	CBL_MET	334:336	Mutation rewiring degron network	0.2778
p.R338H	DO43843	UCEC	ICGC	DYR	CBL_MET	334:336	Mutation rewiring degron network	0.2778
p.K341R	DO234230	ESAD	ICGC	DYR	CBL_MET	334:336	Mutation substituting flanking lysine	0.3056
p.K341R	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	DYR	CBL_MET	334:336	Mutation substituting flanking lysine	0.3056
p.K341R	ACH-002046	Endometrial/Uterine Cancer	CCLE	DYR	CBL_MET	334:336	Mutation substituting flanking lysine	0.3056
p.R336C	DO228584	MALY	ICGC	DYR	CBL_MET	334:336	Mutation altering degron motif	0.8301
p.M324I	DO218874	SKCA	ICGC	DYR	CBL_MET	334:336	Mutation rewiring degron network	0.0556
p.R346Q	SIDM01770	Gastric Carcinoma	GDSC	DYR	CBL_MET	334:336	Mutation rewiring degron network	0.0556
p.R346Q	ACH-000908	Gastric Cancer	CCLE	DYR	CBL_MET	334:336	Mutation rewiring degron network	0.0556

Kaplan plot for WDR55 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WDR55

UniProt ID: Q9H6Y2

Entrez ID: 54853

Protein name: WD repeat-containing protein 55

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WDR55 in