DegronMD - Q86UW6(N4BP2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A149V	TCGA-AA-A010	COAD	TCGA	DDQVYSFLP	CBL_PTK	158:166	Mutation rewiring degron network	0.0833
p.S184L	TCGA-AD-5900	COAD	TCGA	MTPIFS	DEG_SCF_FBW7_1	187:192	Mutation rewiring degron network	0.25
p.S184L	DO8514	COAD	ICGC	MTPIFS	DEG_SCF_FBW7_1	187:192	Mutation rewiring degron network	0.25
p.D1620V	TCGA-BH-A203	BRCA	TCGA	DYR	CBL_MET	1621:1623	Mutation rewiring degron network	0.3056
p.D1620V	DO2156	BRCA	ICGC	DYR	CBL_MET	1621:1623	Mutation rewiring degron network	0.3056
p.V1176M	TCGA-BS-A0UA	UCEC	TCGA	ENSNSPVPEF	DEG_COP1_1	1170:1179	Mutation altering degron motif	0.7208
p.V1176M	DO42552	UCEC	ICGC	ENSNSPVPEF	DEG_COP1_1	1170:1179	Mutation altering degron motif	0.7208
p.N202H	TCGA-CA-6717	COAD	TCGA	MTPIFS	DEG_SCF_FBW7_1	187:192	Mutation rewiring degron network	0.0556
p.N202H	DO8264	COAD	ICGC	MTPIFS	DEG_SCF_FBW7_1	187:192	Mutation rewiring degron network	0.0556
p.P1175S	TCGA-DK-A1AC	BLCA	TCGA	ENSNSPVPEF	DEG_COP1_1	1170:1179	Mutation altering degron motif	0.5641
p.P1175S	DO514	BLCA	ICGC	ENSNSPVPEF	DEG_COP1_1	1170:1179	Mutation altering degron motif	0.5641
p.R1623K	TCGA-DK-A1AC	BLCA	TCGA	DYR	CBL_MET	1621:1623	Mutation altering degron motif	0.7237
p.R1623K	DO514	BLCA	ICGC	DYR	CBL_MET	1621:1623	Mutation altering degron motif	0.7237
p.S1172Y	TCGA-F5-6814	READ	TCGA	ENSNSPVPEF	DEG_COP1_1	1170:1179	Mutation altering degron motif	0.8231
p.S1172Y	DO36556	READ	ICGC	ENSNSPVPEF	DEG_COP1_1	1170:1179	Mutation altering degron motif	0.8231
p.A1626T	TCGA-FI-A2D5	UCEC	TCGA	DYR	CBL_MET	1621:1623	Mutation rewiring degron network	0.25
p.A1626T	DO41331	UCEC	ICGC	DYR	CBL_MET	1621:1623	Mutation rewiring degron network	0.25
p.D1618N	TCGA-JY-A6FG	ESCA	TCGA	DYR	CBL_MET	1621:1623	Mutation rewiring degron network	0.25
p.P182T	TCGA-PG-A6IB	UCEC	TCGA	MTPIFS	DEG_SCF_FBW7_1	187:192	Mutation rewiring degron network	0.1944
p.P182T	DO52419	UCEC	ICGC	MTPIFS	DEG_SCF_FBW7_1	187:192	Mutation rewiring degron network	0.1944
p.R1633T	DO227947	BRCA	ICGC	DYR	CBL_MET	1621:1623	Mutation rewiring degron network	0.0556
p.E1625Q	DO223015	ESCA	ICGC	DYR	CBL_MET	1621:1623	Mutation rewiring degron network	0.2778
p.R1633S	DO228985	LICA	ICGC	DYR	CBL_MET	1621:1623	Mutation rewiring degron network	0.0556
p.D1189Y	DO229035	LICA	ICGC	ENSNSPVPEF	DEG_COP1_1	1170:1179	Mutation rewiring degron network	0.0556
p.Q1630K	DO229053	LICA	ICGC	DYR	CBL_MET	1621:1623	Mutation rewiring degron network	0.1389
p.D1621G	DO228338	MALY	ICGC	DYR	CBL_MET	1621:1623	Mutation altering degron motif	0.7198
p.D1621G	SIDM00948	Burkitt's Lymphoma	GDSC	DYR	CBL_MET	1621:1623	Mutation altering degron motif	0.7198
p.D1621G	ACH-002232	Lymphoma	CCLE	DYR	CBL_MET	1621:1623	Mutation altering degron motif	0.7198
p.D1621G	DG-75	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	1621:1623	Mutation altering degron motif	0.7198
p.M196V	SIDM01265	Plasma Cell Myeloma	GDSC	MTPIFS	DEG_SCF_FBW7_1	187:192	Mutation rewiring degron network	0.2222
p.M196V	SIDM00845	Burkitt's Lymphoma	GDSC	MTPIFS	DEG_SCF_FBW7_1	187:192	Mutation rewiring degron network	0.2222
p.M196V	SIDM00087	Plasma Cell Myeloma	GDSC	MTPIFS	DEG_SCF_FBW7_1	187:192	Mutation rewiring degron network	0.2222
p.M196V	SIDM00654	Small Cell Lung Carcinoma	GDSC	MTPIFS	DEG_SCF_FBW7_1	187:192	Mutation rewiring degron network	0.2222
p.M196V	SIDM00257	Neuroblastoma	GDSC	MTPIFS	DEG_SCF_FBW7_1	187:192	Mutation rewiring degron network	0.2222
p.M196V	SIDM01318	Hepatocellular Carcinoma	GDSC	MTPIFS	DEG_SCF_FBW7_1	187:192	Mutation rewiring degron network	0.2222
p.M196V	SIDM01686	Chronic Myelogenous Leukemia	GDSC	MTPIFS	DEG_SCF_FBW7_1	187:192	Mutation rewiring degron network	0.2222
p.M196V	SIDM01590	Breast Carcinoma	GDSC	MTPIFS	DEG_SCF_FBW7_1	187:192	Mutation rewiring degron network	0.2222
p.R1166I	SIDM00719	Small Cell Lung Carcinoma	GDSC	ENSNSPVPEF	DEG_COP1_1	1170:1179	Mutation rewiring degron network	0.2222
p.R1166I	ACH-001364	Lung Cancer	CCLE	ENSNSPVPEF	DEG_COP1_1	1170:1179	Mutation rewiring degron network	0.2222
p.R1166I	NCI-H345	lung	COSMIC	ENSNSPVPEF	DEG_COP1_1	1170:1179	Mutation rewiring degron network	0.2222
p.D158G	SIDM00333	Endometrial Carcinoma	GDSC	DDQVYSFLP	CBL_PTK	158:166	Mutation altering degron motif	0.7198
p.D158G	ACH-000988	Endometrial/Uterine Cancer	CCLE	DDQVYSFLP	CBL_PTK	158:166	Mutation altering degron motif	0.7198
p.D158G	MFE-319	endometrium	COSMIC	DDQVYSFLP	CBL_PTK	158:166	Mutation altering degron motif	0.7198
p.D159Y	SIDM00118	Colorectal Carcinoma	GDSC	DDQVYSFLP	CBL_PTK	158:166	Mutation altering degron motif	0.6214
p.D159Y	ACH-001081	Colon/Colorectal Cancer	CCLE	DDQVYSFLP	CBL_PTK	158:166	Mutation altering degron motif	0.6214
p.D159Y	HCC2998	large intestine	COSMIC	DDQVYSFLP	CBL_PTK	158:166	Mutation altering degron motif	0.6214
p.S172G	ACH-001647	Leukemia	CCLE	DDQVYSFLP	CBL_PTK	158:166	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

N4BP2

UniProt ID: Q86UW6

Entrez ID: 55728

Protein name: NEDD4-binding protein 2 (N4BP2) (EC 3.-.-.-) (BCL-3-binding protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for N4BP2 in