DegronMD

Uniprot ID: Q86UW6

Source protein: NEDD4-binding protein 2

Source gene: N4BP2

Class: DEG_COP1_1

Location: 1170:1179

E3 ligase: COP1

DEGRON score: 0.7426

ASA_SCORE: 92.75

COIL: 0.7726

CONS_SCORE: 0.3529

DSS_SCORE: 0.5513

HELIX: 0.0797

FCONS_SCORE: 0.9976

RIG_SCORE: 0.655

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1176M	TCGA-BS-A0UA	UCEC	TCGA	ENSNSPVPEF	DEG_COP1_1	0.7208
p.V1176M	DO42552	UCEC	ICGC	ENSNSPVPEF	DEG_COP1_1	0.7208
p.P1175S	TCGA-DK-A1AC	BLCA	TCGA	ENSNSPVPEF	DEG_COP1_1	0.5641
p.P1175S	DO514	BLCA	ICGC	ENSNSPVPEF	DEG_COP1_1	0.5641
p.S1172Y	TCGA-F5-6814	READ	TCGA	ENSNSPVPEF	DEG_COP1_1	0.8231
p.S1172Y	DO36556	READ	ICGC	ENSNSPVPEF	DEG_COP1_1	0.8231
p.D1189Y	DO229035	LICA	ICGC	ENSNSPVPEF	DEG_COP1_1	0.0556
p.R1166I	SIDM00719	Small Cell Lung Carcinoma	GDSC	ENSNSPVPEF	DEG_COP1_1	0.2222
p.R1166I	ACH-001364	Lung Cancer	CCLE	ENSNSPVPEF	DEG_COP1_1	0.2222
p.R1166I	NCI-H345	lung	COSMIC	ENSNSPVPEF	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UW6	NEDD4-binding protein 2	DEG_COP1_1	1170:1179	ENSNSPVPEF	COP1	0.7426	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons