DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
DDQVYSFLP
Uniprot ID:
Q86UW6
Source protein:
NEDD4-binding protein 2
Source gene:
N4BP2
Class:
CBL_PTK
Location:
158:166
E3 ligase:
CBL
DEGRON score:
0.9632
ASA_SCORE:
80.3111
COIL:
0.7503
CONS_SCORE:
0.3428
DSS_SCORE:
0.4933
HELIX:
0.1422
FCONS_SCORE:
0.9117
RIG_SCORE:
0.7546
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A149V
TCGA-AA-A010
COAD
TCGA
DDQVYSFLP
CBL_PTK
0.0833
p.D158G
SIDM00333
Endometrial Carcinoma
GDSC
DDQVYSFLP
CBL_PTK
0.7198
p.D158G
ACH-000988
Endometrial/Uterine Cancer
CCLE
DDQVYSFLP
CBL_PTK
0.7198
p.D158G
MFE-319
endometrium
COSMIC
DDQVYSFLP
CBL_PTK
0.7198
p.D159Y
SIDM00118
Colorectal Carcinoma
GDSC
DDQVYSFLP
CBL_PTK
0.6214
p.D159Y
ACH-001081
Colon/Colorectal Cancer
CCLE
DDQVYSFLP
CBL_PTK
0.6214
p.D159Y
HCC2998
large_intestine
COSMIC
DDQVYSFLP
CBL_PTK
0.6214
p.S172G
ACH-001647
Leukemia
CCLE
DDQVYSFLP
CBL_PTK
0.1667
Drug responses associated with N4BP2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DDQVYSFLP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q86UW6
NEDD4-binding protein 2
CBL_PTK
158:166
DDQVYSFLP
CBL
0.9632
More...
