DegronMD

Uniprot ID: Q86UW6

Source protein: NEDD4-binding protein 2

Source gene: N4BP2

Class: DEG_SCF_FBW7_1

Location: 187:192

E3 ligase: FBXW7

DEGRON score: 0.9723

ASA_SCORE: 76.6833

COIL: 0.8925

CONS_SCORE: 0.3467

DSS_SCORE: 0.5473

HELIX: 0.0467

FCONS_SCORE: 0.9778

RIG_SCORE: 0.74

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S184L	TCGA-AD-5900	COAD	TCGA	MTPIFS	DEG_SCF_FBW7_1	0.25
p.S184L	DO8514	COAD	ICGC	MTPIFS	DEG_SCF_FBW7_1	0.25
p.N202H	TCGA-CA-6717	COAD	TCGA	MTPIFS	DEG_SCF_FBW7_1	0.0556
p.N202H	DO8264	COAD	ICGC	MTPIFS	DEG_SCF_FBW7_1	0.0556
p.P182T	TCGA-PG-A6IB	UCEC	TCGA	MTPIFS	DEG_SCF_FBW7_1	0.1944
p.P182T	DO52419	UCEC	ICGC	MTPIFS	DEG_SCF_FBW7_1	0.1944
p.M196V	SIDM01265	Plasma Cell Myeloma	GDSC	MTPIFS	DEG_SCF_FBW7_1	0.2222
p.M196V	SIDM00845	Burkitt's Lymphoma	GDSC	MTPIFS	DEG_SCF_FBW7_1	0.2222
p.M196V	SIDM00087	Plasma Cell Myeloma	GDSC	MTPIFS	DEG_SCF_FBW7_1	0.2222
p.M196V	SIDM00654	Small Cell Lung Carcinoma	GDSC	MTPIFS	DEG_SCF_FBW7_1	0.2222
p.M196V	SIDM00257	Neuroblastoma	GDSC	MTPIFS	DEG_SCF_FBW7_1	0.2222
p.M196V	SIDM01318	Hepatocellular Carcinoma	GDSC	MTPIFS	DEG_SCF_FBW7_1	0.2222
p.M196V	SIDM01686	Chronic Myelogenous Leukemia	GDSC	MTPIFS	DEG_SCF_FBW7_1	0.2222
p.M196V	SIDM01590	Breast Carcinoma	GDSC	MTPIFS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UW6	NEDD4-binding protein 2	DEG_SCF_FBW7_1	187:192	MTPIFS	FBXW7	0.9723	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons