DegronMD - Q9UN70(PCDHGC3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T411A	TCGA-AJ-A3EL	UCEC	TCGA	DLDRETVPEY	DEG_COP1_1	414:423	Mutation rewiring degron network	0.25
p.T411A	DO41542	UCEC	ICGC	DLDRETVPEY	DEG_COP1_1	414:423	Mutation rewiring degron network	0.25
p.K404N	TCGA-D1-A16Y	UCEC	TCGA	DLDRETVPEY	DEG_COP1_1	414:423	Mutation substituting flanking lysine	0.1667
p.K404N	DO41524	UCEC	ICGC	DLDRETVPEY	DEG_COP1_1	414:423	Mutation substituting flanking lysine	0.1667
p.A429T	TCGA-G4-6320	COAD	TCGA	DLDRETVPEY	DEG_COP1_1	414:423	Mutation rewiring degron network	0.1667
p.A429T	DO8159	COAD	ICGC	DLDRETVPEY	DEG_COP1_1	414:423	Mutation rewiring degron network	0.1667
p.R430Q	DO227996	COCA	ICGC	DLDRETVPEY	DEG_COP1_1	414:423	Mutation rewiring degron network	0.1389
p.R430Q	SIDM00111	Glioma	GDSC	DLDRETVPEY	DEG_COP1_1	414:423	Mutation rewiring degron network	0.1389
p.R430Q	SIDM00707	Non-Cancerous	GDSC	DLDRETVPEY	DEG_COP1_1	414:423	Mutation rewiring degron network	0.1389
p.R430Q	SIDM00905	Cervical Carcinoma	GDSC	DLDRETVPEY	DEG_COP1_1	414:423	Mutation rewiring degron network	0.1389
p.R430Q	SIDM00467	Acute Myeloid Leukemia	GDSC	DLDRETVPEY	DEG_COP1_1	414:423	Mutation rewiring degron network	0.1389
p.P900T	DO233115	GACA	ICGC	DYR	CBL_MET	892:894	Mutation rewiring degron network	0.1667
p.R417L	DO229015	LICA	ICGC	DLDRETVPEY	DEG_COP1_1	414:423	Mutation altering degron motif	0.7316
p.A432S	DO229009	LICA	ICGC	DLDRETVPEY	DEG_COP1_1	414:423	Mutation rewiring degron network	0.0833
p.V890M	DO25554	LUAD	ICGC	DYR	CBL_MET	892:894	Mutation rewiring degron network	0.2778
p.V890M	SLVL	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	892:894	Mutation rewiring degron network	0.2778
p.E418D	DO230934	LUSC	ICGC	DLDRETVPEY	DEG_COP1_1	414:423	Mutation altering degron motif	0.5647
p.V897G	DO28089	OV	ICGC	DYR	CBL_MET	892:894	Mutation rewiring degron network	0.25
p.T886A	DO48918	PBCA	ICGC	DYR	CBL_MET	892:894	Mutation rewiring degron network	0.1667
p.R894H	DO41871	UCEC	ICGC	DYR	CBL_MET	892:894	Mutation altering degron motif	0.8244
p.R894C	DO42568	UCEC	ICGC	DYR	CBL_MET	892:894	Mutation altering degron motif	0.8301
p.S412G	SIDM01045	Endometrial Carcinoma	GDSC	DLDRETVPEY	DEG_COP1_1	414:423	Mutation rewiring degron network	0.2778
p.S412G	ACH-000978	Endometrial/Uterine Cancer	CCLE	DLDRETVPEY	DEG_COP1_1	414:423	Mutation rewiring degron network	0.2778
p.S412G	EN	endometrium	COSMIC	DLDRETVPEY	DEG_COP1_1	414:423	Mutation rewiring degron network	0.2778

Kaplan plot for PCDHGC3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCDHGC3

UniProt ID: Q9UN70

Entrez ID: 5098

Protein name: Protocadherin gamma-C3 (PCDH-gamma-C3) (Protocadherin-2) (Protocadherin-43) (PC-43)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PCDHGC3 in