DegronMD

Uniprot ID: Q9UN70

Source protein: Protocadherin gamma-C3

Source gene: PCDHGC3

Class: DEG_COP1_1

Location: 414:423

E3 ligase: COP1

DEGRON score: 0.6696

ASA_SCORE: 73.9

COIL: 0.8095

CONS_SCORE: 0.6037

DSS_SCORE: 0.3092

HELIX: 0.065

FCONS_SCORE: 1.0953

RIG_SCORE: 0.8156

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T411A	TCGA-AJ-A3EL	UCEC	TCGA	DLDRETVPEY	DEG_COP1_1	0.25
p.T411A	DO41542	UCEC	ICGC	DLDRETVPEY	DEG_COP1_1	0.25
p.K404N	TCGA-D1-A16Y	UCEC	TCGA	DLDRETVPEY	DEG_COP1_1	0.1667
p.K404N	DO41524	UCEC	ICGC	DLDRETVPEY	DEG_COP1_1	0.1667
p.A429T	TCGA-G4-6320	COAD	TCGA	DLDRETVPEY	DEG_COP1_1	0.1667
p.A429T	DO8159	COAD	ICGC	DLDRETVPEY	DEG_COP1_1	0.1667
p.R430Q	DO227996	COCA	ICGC	DLDRETVPEY	DEG_COP1_1	0.1389
p.R430Q	SIDM00111	Glioma	GDSC	DLDRETVPEY	DEG_COP1_1	0.1389
p.R430Q	SIDM00707	Non-Cancerous	GDSC	DLDRETVPEY	DEG_COP1_1	0.1389
p.R430Q	SIDM00905	Cervical Carcinoma	GDSC	DLDRETVPEY	DEG_COP1_1	0.1389
p.R430Q	SIDM00467	Acute Myeloid Leukemia	GDSC	DLDRETVPEY	DEG_COP1_1	0.1389
p.R417L	DO229015	LICA	ICGC	DLDRETVPEY	DEG_COP1_1	0.7316
p.A432S	DO229009	LICA	ICGC	DLDRETVPEY	DEG_COP1_1	0.0833
p.E418D	DO230934	LUSC	ICGC	DLDRETVPEY	DEG_COP1_1	0.5647
p.S412G	SIDM01045	Endometrial Carcinoma	GDSC	DLDRETVPEY	DEG_COP1_1	0.2778
p.S412G	ACH-000978	Endometrial/Uterine Cancer	CCLE	DLDRETVPEY	DEG_COP1_1	0.2778
p.S412G	EN	endometrium	COSMIC	DLDRETVPEY	DEG_COP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UN70	Protocadherin gamma-C3	DEG_COP1_1	414:423	DLDRETVPEY	COP1	0.6696	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons