DegronMD - Q12802(AKAP13)

FUNCTION: Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:25186459, PubMed:24993829). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:23716597, PubMed:21224381). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:9627117, PubMed:11579095). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}. View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E2574D	TCGA-37-4133	LUSC	TCGA	QRQDLANLQ	DEG_APCC_DBOX_1	2580:2588	Mutation rewiring degron network	0.1667
p.E2574D	DO26465	LUSC	ICGC	QRQDLANLQ	DEG_APCC_DBOX_1	2580:2588	Mutation rewiring degron network	0.1667
p.S943P	TCGA-66-2766	LUSC	TCGA	IKENA	DEG_APCC_KENBOX_2	937:941	Mutation rewiring degron network	0.2778
p.S943P	DO27747	LUSC	ICGC	IKENA	DEG_APCC_KENBOX_2	937:941	Mutation rewiring degron network	0.2778
p.S395Y	TCGA-A5-A0G2	UCEC	TCGA	DSGTVS	DEG_SCF_TRCP1_1	390:395	Mutation altering degron motif	0.8231
p.S395Y	DO41235	UCEC	ICGC	DSGTVS	DEG_SCF_TRCP1_1	390:395	Mutation altering degron motif	0.8231
p.V389M	TCGA-AP-A1DK	UCEC	TCGA	DSGTVS	DEG_SCF_TRCP1_1	390:395	Mutation rewiring degron network	0.3056
p.V389M	DO42033	UCEC	ICGC	DSGTVS	DEG_SCF_TRCP1_1	390:395	Mutation rewiring degron network	0.3056
p.V389M	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	DSGTVS	DEG_SCF_TRCP1_1	390:395	Mutation rewiring degron network	0.3056
p.V389M	ACH-000852	Lung Cancer	CCLE	DSGTVS	DEG_SCF_TRCP1_1	390:395	Mutation rewiring degron network	0.3056
p.V389M	NCI-H1435	lung	COSMIC	DSGTVS	DEG_SCF_TRCP1_1	390:395	Mutation rewiring degron network	0.3056
p.G827D	TCGA-B5-A0JV	UCEC	TCGA	DYR	CBL_MET	823:825	Mutation rewiring degron network	0.2778
p.G827D	DO43979	UCEC	ICGC	DYR	CBL_MET	823:825	Mutation rewiring degron network	0.2778
p.H819R	TCGA-CK-5915	COAD	TCGA	DYR	CBL_MET	823:825	Mutation rewiring degron network	0.2222
p.H819R	DO7862	COAD	ICGC	DYR	CBL_MET	823:825	Mutation rewiring degron network	0.2222
p.S2570I	TCGA-EE-A2MM	SKCM	TCGA	QRQDLANLQ	DEG_APCC_DBOX_1	2580:2588	Mutation rewiring degron network	0.0556
p.S2570I	DO37770	SKCM	ICGC	QRQDLANLQ	DEG_APCC_DBOX_1	2580:2588	Mutation rewiring degron network	0.0556
p.Q2586R	TCGA-HF-7132	STAD	TCGA	QRQDLANLQ	DEG_APCC_DBOX_1	2580:2588	Mutation altering degron motif	0.7329
p.Q2586R	DO38214	STAD	ICGC	QRQDLANLQ	DEG_APCC_DBOX_1	2580:2588	Mutation altering degron motif	0.7329
p.S933C	DO51229	BRCA	ICGC	IKENA	DEG_APCC_KENBOX_2	937:941	Mutation rewiring degron network	0.2222
p.Q2597E	DO229331	BTCA	ICGC	QRQDLANLQ	DEG_APCC_DBOX_1	2580:2588	Mutation rewiring degron network	0.0833
p.K938T	DO223380	CLLE	ICGC	IKENA	DEG_APCC_KENBOX_2	937:941	Mutation altering degron motif	0.7306
p.F945L	DO15046	HNSC	ICGC	IKENA	DEG_APCC_KENBOX_2	937:941	Mutation rewiring degron network	0.2222
p.V391G	DO22978	LIHC	ICGC	DSGTVS	DEG_SCF_TRCP1_1	390:395	Mutation altering degron motif	0.7532
p.T396A	DO45299	LIRI	ICGC	DSGTVS	DEG_SCF_TRCP1_1	390:395	Mutation rewiring degron network	0.3056
p.R381S	DO23612	LUAD	ICGC	DSGTVS	DEG_SCF_TRCP1_1	390:395	Mutation rewiring degron network	0.0833
p.P943A	DO23598	LUAD	ICGC	IKENA	DEG_APCC_KENBOX_2	937:941	Mutation rewiring degron network	0.2778
p.L404V	DO228465	MALY	ICGC	DSGTVS	DEG_SCF_TRCP1_1	390:395	Mutation rewiring degron network	0.0833
p.E834V	DO51474	PACA	ICGC	DYR	CBL_MET	823:825	Mutation rewiring degron network	0.0833
p.E951K	DO37454	SKCM	ICGC	IKENA	DEG_APCC_KENBOX_2	937:941	Mutation rewiring degron network	0.0556
p.M940I	DO47407	SKCM	ICGC	IKENA	DEG_APCC_KENBOX_2	937:941	Mutation altering degron motif	0.7618
p.V400I	DO47309	SKCM	ICGC	DSGTVS	DEG_SCF_TRCP1_1	390:395	Mutation rewiring degron network	0.1944
p.V400I	DO223286	UCEC	ICGC	DSGTVS	DEG_SCF_TRCP1_1	390:395	Mutation rewiring degron network	0.1944
p.R394Q	DO41572	UCEC	ICGC	DSGTVS	DEG_SCF_TRCP1_1	390:395	Mutation altering degron motif	0.7329
p.Y824F	SIDM00376	B-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	823:825	Mutation altering degron motif	0.7528
p.Y824F	SIDM00509	Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	823:825	Mutation altering degron motif	0.7528
p.Y824F	SIDM01184	Bladder Carcinoma	GDSC	DYR	CBL_MET	823:825	Mutation altering degron motif	0.7528
p.Y824F	SIDM00258	Neuroblastoma	GDSC	DYR	CBL_MET	823:825	Mutation altering degron motif	0.7528
p.Y824F	SIDM00277	Acute Myeloid Leukemia	GDSC	DYR	CBL_MET	823:825	Mutation altering degron motif	0.7528
p.Y824F	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	823:825	Mutation altering degron motif	0.7528
p.Y824F	SIDM00039	Ovarian Carcinoma	GDSC	DYR	CBL_MET	823:825	Mutation altering degron motif	0.7528
p.Y824F	SIDM01696	Mesothelioma	GDSC	DYR	CBL_MET	823:825	Mutation altering degron motif	0.7528
p.G380A	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	DSGTVS	DEG_SCF_TRCP1_1	390:395	Mutation rewiring degron network	0.0556
p.G380A	SIDM00239	Kidney Carcinoma	GDSC	DSGTVS	DEG_SCF_TRCP1_1	390:395	Mutation rewiring degron network	0.0556
p.G380A	SIDM01335	Kidney Carcinoma	GDSC	DSGTVS	DEG_SCF_TRCP1_1	390:395	Mutation rewiring degron network	0.0556
p.G380A	OS-RC-2	kidney	COSMIC	DSGTVS	DEG_SCF_TRCP1_1	390:395	Mutation rewiring degron network	0.0556
p.G380A	TE-1	oesophagus	COSMIC	DSGTVS	DEG_SCF_TRCP1_1	390:395	Mutation rewiring degron network	0.0556
p.Q397P	SIDM00685	Glioblastoma	GDSC	DSGTVS	DEG_SCF_TRCP1_1	390:395	Mutation rewiring degron network	0.2778
p.Q397P	ACH-000819	Brain Cancer	CCLE	DSGTVS	DEG_SCF_TRCP1_1	390:395	Mutation rewiring degron network	0.2778
p.Q397P	LN-18	central nervous system	COSMIC	DSGTVS	DEG_SCF_TRCP1_1	390:395	Mutation rewiring degron network	0.2778
p.R2579H	SIDM00380	Acute Myeloid Leukemia	GDSC	QRQDLANLQ	DEG_APCC_DBOX_1	2580:2588	Mutation rewiring degron network	0.3056
p.R2579H	ACH-000373	Leukemia	CCLE	QRQDLANLQ	DEG_APCC_DBOX_1	2580:2588	Mutation rewiring degron network	0.3056
p.R2579H	SKM-1	haematopoietic and lymphoid tissue	COSMIC	QRQDLANLQ	DEG_APCC_DBOX_1	2580:2588	Mutation rewiring degron network	0.3056
p.E2576D	ACH-001688	Kidney Cancer	CCLE	QRQDLANLQ	DEG_APCC_DBOX_1	2580:2588	Mutation rewiring degron network	0.2222
p.R816C	NALM-6	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	823:825	Mutation rewiring degron network	0.1389
p.R816H	SU-DHL-6	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	823:825	Mutation rewiring degron network	0.1389
p.R821C	NALM-6	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	823:825	Mutation rewiring degron network	0.2778
p.R821H	SU-DHL-6	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	823:825	Mutation rewiring degron network	0.2778
p.R2575H	SKM-1	haematopoietic and lymphoid tissue	COSMIC	QRQDLANLQ	DEG_APCC_DBOX_1	2580:2588	Mutation rewiring degron network	0.1944

Kaplan plot for AKAP13 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AKAP13

UniProt ID: Q12802

Entrez ID: 11214

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AKAP13 in