DegronMD

Uniprot ID: Q12802

Source protein: A-kinase anchor protein 13

Source gene: AKAP13

Class: DEG_APCC_KENBOX_2

Location: 937:941

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7472

ASA_SCORE: 103.1

COIL: 0.5458

CONS_SCORE: 0.3069

DSS_SCORE: 0.5111

HELIX: 0.415

FCONS_SCORE: 0.986

RIG_SCORE: 0.7022

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S943P	TCGA-66-2766	LUSC	TCGA	IKENA	DEG_APCC_KENBOX_2	0.2778
p.S943P	DO27747	LUSC	ICGC	IKENA	DEG_APCC_KENBOX_2	0.2778
p.S933C	DO51229	BRCA	ICGC	IKENA	DEG_APCC_KENBOX_2	0.2222
p.K938T	DO223380	CLLE	ICGC	IKENA	DEG_APCC_KENBOX_2	0.7306
p.F945L	DO15046	HNSC	ICGC	IKENA	DEG_APCC_KENBOX_2	0.2222
p.P943A	DO23598	LUAD	ICGC	IKENA	DEG_APCC_KENBOX_2	0.2778
p.E951K	DO37454	SKCM	ICGC	IKENA	DEG_APCC_KENBOX_2	0.0556
p.M940I	DO47407	SKCM	ICGC	IKENA	DEG_APCC_KENBOX_2	0.7618

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12802	A-kinase anchor protein 13	DEG_APCC_KENBOX_2	937:941	IKENA	APC,CDC20,FZR1	0.7472	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons