DegronMD

Uniprot ID: Q12802

Source protein: A-kinase anchor protein 13

Source gene: AKAP13

Class: DEG_SCF_TRCP1_1

Location: 390:395

E3 ligase: BTRC

DEGRON score: 0.9959

ASA_SCORE: 69.3333

COIL: 0.8238

CONS_SCORE: 0.3128

DSS_SCORE: 0.5522

HELIX: 0.041

FCONS_SCORE: 0.9703

RIG_SCORE: 0.6972

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S395Y	TCGA-A5-A0G2	UCEC	TCGA	DSGTVS	DEG_SCF_TRCP1_1	0.8231
p.S395Y	DO41235	UCEC	ICGC	DSGTVS	DEG_SCF_TRCP1_1	0.8231
p.V389M	TCGA-AP-A1DK	UCEC	TCGA	DSGTVS	DEG_SCF_TRCP1_1	0.3056
p.V389M	DO42033	UCEC	ICGC	DSGTVS	DEG_SCF_TRCP1_1	0.3056
p.V389M	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	DSGTVS	DEG_SCF_TRCP1_1	0.3056
p.V389M	ACH-000852	Lung Cancer	CCLE	DSGTVS	DEG_SCF_TRCP1_1	0.3056
p.V389M	NCI-H1435	lung	COSMIC	DSGTVS	DEG_SCF_TRCP1_1	0.3056
p.V391G	DO22978	LIHC	ICGC	DSGTVS	DEG_SCF_TRCP1_1	0.7532
p.T396A	DO45299	LIRI	ICGC	DSGTVS	DEG_SCF_TRCP1_1	0.3056
p.R381S	DO23612	LUAD	ICGC	DSGTVS	DEG_SCF_TRCP1_1	0.0833
p.L404V	DO228465	MALY	ICGC	DSGTVS	DEG_SCF_TRCP1_1	0.0833
p.V400I	DO47309	SKCM	ICGC	DSGTVS	DEG_SCF_TRCP1_1	0.1944
p.V400I	DO223286	UCEC	ICGC	DSGTVS	DEG_SCF_TRCP1_1	0.1944
p.R394Q	DO41572	UCEC	ICGC	DSGTVS	DEG_SCF_TRCP1_1	0.7329
p.G380A	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	DSGTVS	DEG_SCF_TRCP1_1	0.0556
p.G380A	SIDM00239	Kidney Carcinoma	GDSC	DSGTVS	DEG_SCF_TRCP1_1	0.0556
p.G380A	SIDM01335	Kidney Carcinoma	GDSC	DSGTVS	DEG_SCF_TRCP1_1	0.0556
p.G380A	OS-RC-2	kidney	COSMIC	DSGTVS	DEG_SCF_TRCP1_1	0.0556
p.G380A	TE-1	oesophagus	COSMIC	DSGTVS	DEG_SCF_TRCP1_1	0.0556
p.Q397P	SIDM00685	Glioblastoma	GDSC	DSGTVS	DEG_SCF_TRCP1_1	0.2778
p.Q397P	ACH-000819	Brain Cancer	CCLE	DSGTVS	DEG_SCF_TRCP1_1	0.2778
p.Q397P	LN-18	central_nervous_system	COSMIC	DSGTVS	DEG_SCF_TRCP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12802	A-kinase anchor protein 13	DEG_SCF_TRCP1_1	390:395	DSGTVS	BTRC	0.9959	More...
Q9NUP1	Biogenesis of lysosome-related organelles complex 1 subunit 4	DEG_SCF_TRCP1_1	29:34	DSGTVS	BTRC	0.6321	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons