DegronMD

Uniprot ID: Q12802

Source protein: A-kinase anchor protein 13

Source gene: AKAP13

Class: DEG_APCC_DBOX_1

Location: 2580:2588

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6063

ASA_SCORE: 98.9444

COIL: 0.0613

CONS_SCORE: 0.5119

DSS_SCORE: 0.5345

HELIX: 0.9406

FCONS_SCORE: 1.0676

RIG_SCORE: 0.7226

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E2574D	TCGA-37-4133	LUSC	TCGA	QRQDLANLQ	DEG_APCC_DBOX_1	0.1667
p.E2574D	DO26465	LUSC	ICGC	QRQDLANLQ	DEG_APCC_DBOX_1	0.1667
p.S2570I	TCGA-EE-A2MM	SKCM	TCGA	QRQDLANLQ	DEG_APCC_DBOX_1	0.0556
p.S2570I	DO37770	SKCM	ICGC	QRQDLANLQ	DEG_APCC_DBOX_1	0.0556
p.Q2586R	TCGA-HF-7132	STAD	TCGA	QRQDLANLQ	DEG_APCC_DBOX_1	0.7329
p.Q2586R	DO38214	STAD	ICGC	QRQDLANLQ	DEG_APCC_DBOX_1	0.7329
p.Q2597E	DO229331	BTCA	ICGC	QRQDLANLQ	DEG_APCC_DBOX_1	0.0833
p.R2579H	SIDM00380	Acute Myeloid Leukemia	GDSC	QRQDLANLQ	DEG_APCC_DBOX_1	0.3056
p.R2579H	ACH-000373	Leukemia	CCLE	QRQDLANLQ	DEG_APCC_DBOX_1	0.3056
p.R2579H	SKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	QRQDLANLQ	DEG_APCC_DBOX_1	0.3056
p.E2576D	ACH-001688	Kidney Cancer	CCLE	QRQDLANLQ	DEG_APCC_DBOX_1	0.2222
p.R2575H	SKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	QRQDLANLQ	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12802	A-kinase anchor protein 13	DEG_APCC_DBOX_1	2580:2588	QRQDLANLQ	APC,CDC20,FZR1	0.6063	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons