DegronMD - Q9NWK9(ZNHIT6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S383Y	TCGA-AA-A010	COAD	TCGA	LKPYID	LIG_APCC_ABBA_1	374:379	Mutation rewiring degron network	0.2222
p.V284M	TCGA-AP-A059	UCEC	TCGA	DYR	CBL_MET	277:279	Mutation rewiring degron network	0.1944
p.R388C	TCGA-AP-A1DV	UCEC	TCGA	LKPYID	LIG_APCC_ABBA_1	374:379	Mutation rewiring degron network	0.0833
p.R388C	TCGA-BS-A0UV	UCEC	TCGA	LKPYID	LIG_APCC_ABBA_1	374:379	Mutation rewiring degron network	0.0833
p.R388C	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	LKPYID	LIG_APCC_ABBA_1	374:379	Mutation rewiring degron network	0.0833
p.R388C	ACH-000904	Lung Cancer	CCLE	LKPYID	LIG_APCC_ABBA_1	374:379	Mutation rewiring degron network	0.0833
p.R388C	ACH-001362	Lung Cancer	CCLE	LKPYID	LIG_APCC_ABBA_1	374:379	Mutation rewiring degron network	0.0833
p.R388C	NCI-H1770	lung	COSMIC	LKPYID	LIG_APCC_ABBA_1	374:379	Mutation rewiring degron network	0.0833
p.D366Y	TCGA-BH-A0HP	BRCA	TCGA	LKPYID	LIG_APCC_ABBA_1	374:379	Mutation rewiring degron network	0.1111
p.D367N	TCGA-CF-A47X	BLCA	TCGA	LKPYID	LIG_APCC_ABBA_1	374:379	Mutation rewiring degron network	0.1389
p.L387I	DO8730	COAD	ICGC	LKPYID	LIG_APCC_ABBA_1	374:379	Mutation rewiring degron network	0.1111
p.R276W	DO219717	KIRP	ICGC	DYR	CBL_MET	277:279	Mutation rewiring degron network	0.3056
p.P383T	DO228974	LICA	ICGC	LKPYID	LIG_APCC_ABBA_1	374:379	Mutation rewiring degron network	0.2222
p.P285T	DO229028	LICA	ICGC	DYR	CBL_MET	277:279	Mutation rewiring degron network	0.1667
p.E369Q	DO219221	LUSC	ICGC	LKPYID	LIG_APCC_ABBA_1	374:379	Mutation rewiring degron network	0.1944
p.R273H	DO46657	PAAD	ICGC	DYR	CBL_MET	277:279	Mutation rewiring degron network	0.2222
p.F269S	DO219503	SKCM	ICGC	DYR	CBL_MET	277:279	Mutation rewiring degron network	0.1111
p.R273C	DO42312	UCEC	ICGC	DYR	CBL_MET	277:279	Mutation rewiring degron network	0.2222
p.R273C	DO41020	UCEC	ICGC	DYR	CBL_MET	277:279	Mutation rewiring degron network	0.2222
p.K368Q	SIDM00529	Breast Carcinoma	GDSC	LKPYID	LIG_APCC_ABBA_1	374:379	Mutation blocking ubiquitination signal	0.6111
p.K368Q	MDA-MB-157	breast	COSMIC	LKPYID	LIG_APCC_ABBA_1	374:379	Mutation blocking ubiquitination signal	0.6111
p.D367G	SIDM00364	B-Lymphoblastic Leukemia	GDSC	LKPYID	LIG_APCC_ABBA_1	374:379	Mutation rewiring degron network	0.1389
p.D367G	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	LKPYID	LIG_APCC_ABBA_1	374:379	Mutation rewiring degron network	0.1389
p.M270L	Mewo	skin	COSMIC	DYR	CBL_MET	277:279	Mutation rewiring degron network	0.1389
p.P383L	ONS-76	central nervous system	COSMIC	LKPYID	LIG_APCC_ABBA_1	374:379	Mutation rewiring degron network	0.2222

Kaplan plot for ZNHIT6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNHIT6

UniProt ID: Q9NWK9

Entrez ID: 54680

Protein name: Box C/D snoRNA protein 1 (Serologically defined breast cancer antigen NY-BR-75) (Zinc finger HIT domain-containing protein 6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNHIT6 in