DegronMD

Uniprot ID: Q9NWK9

Source protein: Box C/D snoRNA protein 1

Source gene: ZNHIT6

Class: LIG_APCC_ABBA_1

Location: 374:379

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5236

ASA_SCORE: 56.3333

COIL: 0.3865

CONS_SCORE: 0.3409

DSS_SCORE: 0.431

HELIX: 0.5938

FCONS_SCORE: 1.0494

RIG_SCORE: 0.806

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S383Y	TCGA-AA-A010	COAD	TCGA	LKPYID	LIG_APCC_ABBA_1	0.2222
p.R388C	TCGA-AP-A1DV	UCEC	TCGA	LKPYID	LIG_APCC_ABBA_1	0.0833
p.R388C	TCGA-BS-A0UV	UCEC	TCGA	LKPYID	LIG_APCC_ABBA_1	0.0833
p.R388C	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	LKPYID	LIG_APCC_ABBA_1	0.0833
p.R388C	ACH-000904	Lung Cancer	CCLE	LKPYID	LIG_APCC_ABBA_1	0.0833
p.R388C	ACH-001362	Lung Cancer	CCLE	LKPYID	LIG_APCC_ABBA_1	0.0833
p.R388C	NCI-H1770	lung	COSMIC	LKPYID	LIG_APCC_ABBA_1	0.0833
p.D366Y	TCGA-BH-A0HP	BRCA	TCGA	LKPYID	LIG_APCC_ABBA_1	0.1111
p.D367N	TCGA-CF-A47X	BLCA	TCGA	LKPYID	LIG_APCC_ABBA_1	0.1389
p.L387I	DO8730	COAD	ICGC	LKPYID	LIG_APCC_ABBA_1	0.1111
p.P383T	DO228974	LICA	ICGC	LKPYID	LIG_APCC_ABBA_1	0.2222
p.E369Q	DO219221	LUSC	ICGC	LKPYID	LIG_APCC_ABBA_1	0.1944
p.K368Q	SIDM00529	Breast Carcinoma	GDSC	LKPYID	LIG_APCC_ABBA_1	0.6111
p.K368Q	MDA-MB-157	breast	COSMIC	LKPYID	LIG_APCC_ABBA_1	0.6111
p.D367G	SIDM00364	B-Lymphoblastic Leukemia	GDSC	LKPYID	LIG_APCC_ABBA_1	0.1389
p.D367G	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	LKPYID	LIG_APCC_ABBA_1	0.1389
p.P383L	ONS-76	central_nervous_system	COSMIC	LKPYID	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NWK9	Box C/D snoRNA protein 1	LIG_APCC_ABBA_1	374:379	LKPYID	APC,CDC20,FZR1	0.5236	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons