DegronMD - Q9UQQ2(SH2B3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q571R	TCGA-A5-A0GB	UCEC	TCGA	RAIDNQYT	CBL_APS	566:573	Mutation altering degron motif	0.7329
p.L565M	TCGA-AA-A02R	COAD	TCGA	SRSHLRAID	DEG_APCC_DBOX_1	561:569	Mutation altering degron motif	0.711
p.I568T	TCGA-BA-6868	HNSC	TCGA	SRSHLRAID	DEG_APCC_DBOX_1	561:569	Mutation altering degron motif	0.7078
p.I568T	TCGA-BA-6868	HNSC	TCGA	RAIDNQYT	CBL_APS	566:573	Mutation altering degron motif	0.7078
p.I568T	SIDM01242	Melanoma	GDSC	SRSHLRAID	DEG_APCC_DBOX_1	561:569	Mutation altering degron motif	0.7078
p.I568T	SIDM01242	Melanoma	GDSC	RAIDNQYT	CBL_APS	566:573	Mutation altering degron motif	0.7078
p.I568T	SIDM00301	Pancreatic Carcinoma	GDSC	SRSHLRAID	DEG_APCC_DBOX_1	561:569	Mutation altering degron motif	0.7078
p.I568T	SIDM00301	Pancreatic Carcinoma	GDSC	RAIDNQYT	CBL_APS	566:573	Mutation altering degron motif	0.7078
p.I568T	SIDM00619	Thyroid Gland Carcinoma	GDSC	SRSHLRAID	DEG_APCC_DBOX_1	561:569	Mutation altering degron motif	0.7078
p.I568T	SIDM00619	Thyroid Gland Carcinoma	GDSC	RAIDNQYT	CBL_APS	566:573	Mutation altering degron motif	0.7078
p.I568T	SIDM00166	Other Solid Cancers	GDSC	SRSHLRAID	DEG_APCC_DBOX_1	561:569	Mutation altering degron motif	0.7078
p.I568T	SIDM00166	Other Solid Cancers	GDSC	RAIDNQYT	CBL_APS	566:573	Mutation altering degron motif	0.7078
p.I568T	SIDM00171	Colorectal Carcinoma	GDSC	SRSHLRAID	DEG_APCC_DBOX_1	561:569	Mutation altering degron motif	0.7078
p.I568T	SIDM00171	Colorectal Carcinoma	GDSC	RAIDNQYT	CBL_APS	566:573	Mutation altering degron motif	0.7078
p.I568T	KMH-2	thyroid	COSMIC	SRSHLRAID	DEG_APCC_DBOX_1	561:569	Mutation altering degron motif	0.7078
p.I568T	KMH-2	thyroid	COSMIC	RAIDNQYT	CBL_APS	566:573	Mutation altering degron motif	0.7078
p.S561Y	TCGA-CV-7415	HNSC	TCGA	SRSHLRAID	DEG_APCC_DBOX_1	561:569	Mutation altering degron motif	0.6009
p.M557I	TCGA-D1-A16X	UCEC	TCGA	SRSHLRAID	DEG_APCC_DBOX_1	561:569	Mutation rewiring degron network	0.2222
p.M557I	TCGA-D1-A16X	UCEC	TCGA	RAIDNQYT	CBL_APS	566:573	Mutation rewiring degron network	0.0833
p.P574H	TCGA-EL-A3GQ	THCA	TCGA	SRSHLRAID	DEG_APCC_DBOX_1	561:569	Mutation rewiring degron network	0.1944
p.P574H	TCGA-EL-A3GQ	THCA	TCGA	RAIDNQYT	CBL_APS	566:573	Mutation rewiring degron network	0.3056
p.T327M	TCGA-ER-A19E	SKCM	TCGA	PSTSS	DEG_SPOP_SBC_1	325:329	Mutation altering degron motif	0.7423
p.D336H	TCGA-QK-AA3K	HNSC	TCGA	PSTSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.1389
p.A334T	DO230334	COCA	ICGC	PSTSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.1944
p.G315E	DO222755	COCA	ICGC	PSTSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.0556
p.H339Y	DO52438	COCA	ICGC	PSTSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.0556
p.D88N	DO234462	ESAD	ICGC	DYR	CBL_MET	88:90	Mutation altering degron motif	0.6932
p.N94H	DO233173	GACA	ICGC	DYR	CBL_MET	88:90	Mutation rewiring degron network	0.2222
p.H325Y	DO35140	PACA	ICGC	PSTSS	DEG_SPOP_SBC_1	325:329	Mutation altering degron motif	0.7229
p.Q91R	DO47745	STAD	ICGC	DYR	CBL_MET	88:90	Mutation rewiring degron network	0.3056
p.E331K	DO43578	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.2778
p.E321K	DO43186	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.2222
p.E332D	DO41235	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.25
p.R94C	DO229542	UTCA	ICGC	DYR	CBL_MET	88:90	Mutation rewiring degron network	0.2222
p.R566W	SIDM00829	Acute Myeloid Leukemia	GDSC	SRSHLRAID	DEG_APCC_DBOX_1	561:569	Mutation altering degron motif	0.7523
p.R566W	SIDM00829	Acute Myeloid Leukemia	GDSC	RAIDNQYT	CBL_APS	566:573	Mutation altering degron motif	0.8634
p.E324K	SIDM01113	Other Sarcomas	GDSC	PSTSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.3056
p.E324K	ACH-000939	Sarcoma	CCLE	PSTSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.3056
p.E324K	SK-UT-1	soft tissue	COSMIC	PSTSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.3056
p.S337P	SIDM00537	Colorectal Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	325:329	Mutation blocking phosphorylation signal	0.5556
p.S337P	ACH-000982	Colon/Colorectal Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	325:329	Mutation blocking phosphorylation signal	0.5556
p.S337P	ACH-001345	Colon/Colorectal Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	325:329	Mutation blocking phosphorylation signal	0.5556
p.S337P	GP5d	large intestine	COSMIC	PSTSS	DEG_SPOP_SBC_1	325:329	Mutation blocking phosphorylation signal	0.5556
p.S559P	SIDM01664	Prostate Carcinoma	GDSC	SRSHLRAID	DEG_APCC_DBOX_1	561:569	Mutation blocking phosphorylation signal	0.7222
p.S559P	SIDM01664	Prostate Carcinoma	GDSC	RAIDNQYT	CBL_APS	566:573	Mutation blocking phosphorylation signal	0.5833
p.S559P	ACH-000952	Prostate Cancer	CCLE	SRSHLRAID	DEG_APCC_DBOX_1	561:569	Mutation blocking phosphorylation signal	0.7222
p.S559P	ACH-000952	Prostate Cancer	CCLE	RAIDNQYT	CBL_APS	566:573	Mutation blocking phosphorylation signal	0.5833
p.A567V	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	SRSHLRAID	DEG_APCC_DBOX_1	561:569	Mutation altering degron motif	0.5825
p.A567V	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	RAIDNQYT	CBL_APS	566:573	Mutation altering degron motif	0.6936
p.A567V	ACH-000925	Lung Cancer	CCLE	SRSHLRAID	DEG_APCC_DBOX_1	561:569	Mutation altering degron motif	0.5825
p.A567V	ACH-000925	Lung Cancer	CCLE	RAIDNQYT	CBL_APS	566:573	Mutation altering degron motif	0.6936
p.D81G	ACH-000833	Sarcoma	CCLE	DYR	CBL_MET	88:90	Mutation rewiring degron network	0.1389
p.S563G	ACH-002021	Endometrial/Uterine Cancer	CCLE	SRSHLRAID	DEG_APCC_DBOX_1	561:569	Mutation altering degron motif	0.5882
p.S329L	JHOS-4	ovary	COSMIC	PSTSS	DEG_SPOP_SBC_1	325:329	Mutation altering degron motif	0.7667

Kaplan plot for SH2B3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SH2B3

UniProt ID: Q9UQQ2

Entrez ID: 10019

Protein name: SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SH2B3 in