DegronMD - Q9UQQ2(SH2B3)

FUNCTION: Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase. {ECO:0000250}.

GO - Biological processes (BP): cellular response to chemokine [GO:1990869]; cellular response to interleukin-3 [GO:0036016]; embryonic hemopoiesis [GO:0035162]; erythrocyte development [GO:0048821]; intracellular signal transduction [GO:0035556]; megakaryocyte development [GO:0035855]; monocyte homeostasis [GO:0035702]; negative ... View more >>

GO - Molecular function (MF): protein tyrosine kinase binding [GO:1990782]; signaling receptor complex adaptor activity [GO:0030159]; stem cell factor receptor binding [GO:0005173]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]

GO - Cellular component (CC): cytosol [GO:0005829]; plasma membrane [GO:0005886]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R566W	SIDM00829	Acute Myeloid Leukemia	GDSC	RAIDNQYT	CBL_APS	566:573	Mutation altering degron motif	0.8634
p.S329L	JHOS-4	ovary	COSMIC	PSTSS	DEG_SPOP_SBC_1	325:329	Mutation altering degron motif	0.7667
p.R566W	SIDM00829	Acute Myeloid Leukemia	GDSC	SRSHLRAID	DEG_APCC_DBOX_1	561:569	Mutation altering degron motif	0.7523
p.T327M	TCGA-ER-A19E	SKCM	TCGA	PSTSS	DEG_SPOP_SBC_1	325:329	Mutation altering degron motif	0.7423
p.Q571R	TCGA-A5-A0GB	UCEC	TCGA	RAIDNQYT	CBL_APS	566:573	Mutation altering degron motif	0.7329
p.H325Y	DO35140	PACA	ICGC	PSTSS	DEG_SPOP_SBC_1	325:329	Mutation altering degron motif	0.7229
p.S559P	SIDM01664	Prostate Carcinoma	GDSC	SRSHLRAID	DEG_APCC_DBOX_1	561:569	Mutation blocking phosphorylation signal	0.7222
p.S559P	ACH-000952	Prostate Cancer	CCLE	SRSHLRAID	DEG_APCC_DBOX_1	561:569	Mutation blocking phosphorylation signal	0.7222
p.L565M	TCGA-AA-A02R	COAD	TCGA	SRSHLRAID	DEG_APCC_DBOX_1	561:569	Mutation altering degron motif	0.711
p.I568T	TCGA-BA-6868	HNSC	TCGA	SRSHLRAID	DEG_APCC_DBOX_1	561:569	Mutation altering degron motif	0.7078
p.I568T	TCGA-BA-6868	HNSC	TCGA	RAIDNQYT	CBL_APS	566:573	Mutation altering degron motif	0.7078
p.I568T	SIDM01242	Melanoma	GDSC	SRSHLRAID	DEG_APCC_DBOX_1	561:569	Mutation altering degron motif	0.7078
p.I568T	SIDM01242	Melanoma	GDSC	RAIDNQYT	CBL_APS	566:573	Mutation altering degron motif	0.7078
p.I568T	SIDM00301	Pancreatic Carcinoma	GDSC	SRSHLRAID	DEG_APCC_DBOX_1	561:569	Mutation altering degron motif	0.7078
p.I568T	SIDM00301	Pancreatic Carcinoma	GDSC	RAIDNQYT	CBL_APS	566:573	Mutation altering degron motif	0.7078
p.I568T	SIDM00619	Thyroid Gland Carcinoma	GDSC	SRSHLRAID	DEG_APCC_DBOX_1	561:569	Mutation altering degron motif	0.7078
p.I568T	SIDM00619	Thyroid Gland Carcinoma	GDSC	RAIDNQYT	CBL_APS	566:573	Mutation altering degron motif	0.7078
p.I568T	SIDM00166	Other Solid Cancers	GDSC	SRSHLRAID	DEG_APCC_DBOX_1	561:569	Mutation altering degron motif	0.7078
p.I568T	SIDM00166	Other Solid Cancers	GDSC	RAIDNQYT	CBL_APS	566:573	Mutation altering degron motif	0.7078
p.I568T	SIDM00171	Colorectal Carcinoma	GDSC	SRSHLRAID	DEG_APCC_DBOX_1	561:569	Mutation altering degron motif	0.7078

Showing 1 to 20 of 54 entries

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No resistance data available for this Degron.

Kaplan plot for SH2B3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SH2B3

UniProt ID: Q9UQQ2

Entrez ID: 10019

Protein name: SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for SH2B3 in