DegronMD

Uniprot ID: Q9UQQ2

Source protein: SH2B adapter protein 3

Source gene: SH2B3

Class: CBL_APS

Location: 566:573

E3 ligase: CBL

DEGRON score: 0.9885

ASA_SCORE: 67.1125

COIL: 0.4581

CONS_SCORE: 0.6397

DSS_SCORE: 0.7432

HELIX: 0.3168

FCONS_SCORE: 1.5256

RIG_SCORE: 0.7198

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q571R	TCGA-A5-A0GB	UCEC	TCGA	RAIDNQYT	CBL_APS	0.7329
p.I568T	TCGA-BA-6868	HNSC	TCGA	RAIDNQYT	CBL_APS	0.7078
p.I568T	SIDM01242	Melanoma	GDSC	RAIDNQYT	CBL_APS	0.7078
p.I568T	SIDM00301	Pancreatic Carcinoma	GDSC	RAIDNQYT	CBL_APS	0.7078
p.I568T	SIDM00619	Thyroid Gland Carcinoma	GDSC	RAIDNQYT	CBL_APS	0.7078
p.I568T	SIDM00166	Other Solid Cancers	GDSC	RAIDNQYT	CBL_APS	0.7078
p.I568T	SIDM00171	Colorectal Carcinoma	GDSC	RAIDNQYT	CBL_APS	0.7078
p.I568T	KMH-2	thyroid	COSMIC	RAIDNQYT	CBL_APS	0.7078
p.M557I	TCGA-D1-A16X	UCEC	TCGA	RAIDNQYT	CBL_APS	0.0833
p.P574H	TCGA-EL-A3GQ	THCA	TCGA	RAIDNQYT	CBL_APS	0.3056
p.R566W	SIDM00829	Acute Myeloid Leukemia	GDSC	RAIDNQYT	CBL_APS	0.8634
p.S559P	SIDM01664	Prostate Carcinoma	GDSC	RAIDNQYT	CBL_APS	0.5833
p.S559P	ACH-000952	Prostate Cancer	CCLE	RAIDNQYT	CBL_APS	0.5833
p.A567V	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	RAIDNQYT	CBL_APS	0.6936
p.A567V	ACH-000925	Lung Cancer	CCLE	RAIDNQYT	CBL_APS	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQQ2	SH2B adapter protein 3	CBL_APS	566:573	RAIDNQYT	CBL	0.9885	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons