DegronMD

Uniprot ID: Q9UQQ2

Source protein: SH2B adapter protein 3

Source gene: SH2B3

Class: DEG_APCC_DBOX_1

Location: 561:569

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9549

ASA_SCORE: 72.5444

COIL: 0.4553

CONS_SCORE: 0.5285

DSS_SCORE: 0.6182

HELIX: 0.3468

FCONS_SCORE: 1.0943

RIG_SCORE: 0.6877

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L565M	TCGA-AA-A02R	COAD	TCGA	SRSHLRAID	DEG_APCC_DBOX_1	0.711
p.I568T	TCGA-BA-6868	HNSC	TCGA	SRSHLRAID	DEG_APCC_DBOX_1	0.7078
p.I568T	SIDM01242	Melanoma	GDSC	SRSHLRAID	DEG_APCC_DBOX_1	0.7078
p.I568T	SIDM00301	Pancreatic Carcinoma	GDSC	SRSHLRAID	DEG_APCC_DBOX_1	0.7078
p.I568T	SIDM00619	Thyroid Gland Carcinoma	GDSC	SRSHLRAID	DEG_APCC_DBOX_1	0.7078
p.I568T	SIDM00166	Other Solid Cancers	GDSC	SRSHLRAID	DEG_APCC_DBOX_1	0.7078
p.I568T	SIDM00171	Colorectal Carcinoma	GDSC	SRSHLRAID	DEG_APCC_DBOX_1	0.7078
p.I568T	KMH-2	thyroid	COSMIC	SRSHLRAID	DEG_APCC_DBOX_1	0.7078
p.S561Y	TCGA-CV-7415	HNSC	TCGA	SRSHLRAID	DEG_APCC_DBOX_1	0.6009
p.M557I	TCGA-D1-A16X	UCEC	TCGA	SRSHLRAID	DEG_APCC_DBOX_1	0.2222
p.P574H	TCGA-EL-A3GQ	THCA	TCGA	SRSHLRAID	DEG_APCC_DBOX_1	0.1944
p.R566W	SIDM00829	Acute Myeloid Leukemia	GDSC	SRSHLRAID	DEG_APCC_DBOX_1	0.7523
p.S559P	SIDM01664	Prostate Carcinoma	GDSC	SRSHLRAID	DEG_APCC_DBOX_1	0.7222
p.S559P	ACH-000952	Prostate Cancer	CCLE	SRSHLRAID	DEG_APCC_DBOX_1	0.7222
p.A567V	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	SRSHLRAID	DEG_APCC_DBOX_1	0.5825
p.A567V	ACH-000925	Lung Cancer	CCLE	SRSHLRAID	DEG_APCC_DBOX_1	0.5825
p.S563G	ACH-002021	Endometrial/Uterine Cancer	CCLE	SRSHLRAID	DEG_APCC_DBOX_1	0.5882

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQQ2	SH2B adapter protein 3	DEG_APCC_DBOX_1	561:569	SRSHLRAID	APC,CDC20,FZR1	0.9549	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons