DegronMD - Q01668(CACNA1D)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T1744S	TCGA-06-1805	GBM	TCGA	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation rewiring degron network	0.1667
p.R1882S	TCGA-AJ-A2QK	UCEC	TCGA	NYGYYSRYP	CBL_PTK	1864:1872	Mutation rewiring degron network	0.0556
p.R1882S	DO41301	UCEC	ICGC	NYGYYSRYP	CBL_PTK	1864:1872	Mutation rewiring degron network	0.0556
p.P1751S	TCGA-AP-A051	UCEC	TCGA	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation altering degron motif	0.5641
p.S1755L	TCGA-AP-A1DV	UCEC	TCGA	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation rewiring degron network	0.3056
p.S1755L	TCGA-BR-8286	STAD	TCGA	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation rewiring degron network	0.3056
p.S1755L	TCGA-DA-A1IC	SKCM	TCGA	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation rewiring degron network	0.3056
p.S1755L	TCGA-DA-A95X	SKCM	TCGA	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation rewiring degron network	0.3056
p.S1755L	TCGA-E6-A1LX	UCEC	TCGA	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation rewiring degron network	0.3056
p.S1755L	SIDM01307	Colorectal Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation rewiring degron network	0.3056
p.L1860S	TCGA-BS-A0UF	UCEC	TCGA	NYGYYSRYP	CBL_PTK	1864:1872	Mutation rewiring degron network	0.2222
p.L1860S	DO41488	UCEC	ICGC	NYGYYSRYP	CBL_PTK	1864:1872	Mutation rewiring degron network	0.2222
p.K810R	TCGA-D8-A1XK	BRCA	TCGA	DYR	CBL_MET	807:809	Mutation rewiring degron network	0.3056
p.S1868G	TCGA-DK-A1AA	BLCA	TCGA	NYGYYSRYP	CBL_PTK	1864:1872	Mutation altering degron motif	0.6993
p.E1873Q	TCGA-DU-8158	LGG	TCGA	NYGYYSRYP	CBL_PTK	1864:1872	Mutation rewiring degron network	0.3056
p.E1873Q	DO22413	LGG	ICGC	NYGYYSRYP	CBL_PTK	1864:1872	Mutation rewiring degron network	0.3056
p.E1873Q	SIDM00515	Melanoma	GDSC	NYGYYSRYP	CBL_PTK	1864:1872	Mutation rewiring degron network	0.3056
p.E1873Q	COLO-800	skin	COSMIC	NYGYYSRYP	CBL_PTK	1864:1872	Mutation rewiring degron network	0.3056
p.Q815K	TCGA-EE-A2GN	SKCM	TCGA	DYR	CBL_MET	807:809	Mutation substituting flanking lysine	0.2778
p.S1877L	TCGA-ER-A42L	SKCM	TCGA	NYGYYSRYP	CBL_PTK	1864:1872	Mutation rewiring degron network	0.1944
p.S1877L	DO223910	SKCM	ICGC	NYGYYSRYP	CBL_PTK	1864:1872	Mutation rewiring degron network	0.1944
p.P1750L	TCGA-EY-A1GK	UCEC	TCGA	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation altering degron motif	0.7582
p.P1750L	DO42985	UCEC	ICGC	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation altering degron motif	0.7582
p.P1878T	TCGA-FI-A2F4	UCEC	TCGA	NYGYYSRYP	CBL_PTK	1864:1872	Mutation rewiring degron network	0.1667
p.P1878T	DO43434	UCEC	ICGC	NYGYYSRYP	CBL_PTK	1864:1872	Mutation rewiring degron network	0.1667
p.E801K	TCGA-W3-AA1V	SKCM	TCGA	DYR	CBL_MET	807:809	Mutation rewiring degron network	0.1667
p.P1750H	DO50511	BOCA	ICGC	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation altering degron motif	0.7694
p.P1750H	DO227549	COCA	ICGC	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation altering degron motif	0.7694
p.D800N	DO49021	BRCA	ICGC	DYR	CBL_MET	807:809	Mutation rewiring degron network	0.1389
p.E811Q	DO2216	BRCA	ICGC	DYR	CBL_MET	807:809	Mutation rewiring degron network	0.2778
p.R1756W	DO7776	COAD	ICGC	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation rewiring degron network	0.2778
p.R1756W	DO41235	UCEC	ICGC	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation rewiring degron network	0.2778
p.Q1864K	DO234462	ESAD	ICGC	NYGYYSRYP	CBL_PTK	1864:1872	Mutation altering degron motif	0.6944
p.Q1864K	DO47374	SKCM	ICGC	NYGYYSRYP	CBL_PTK	1864:1872	Mutation altering degron motif	0.6944
p.V1874I	DO22237	LGG	ICGC	NYGYYSRYP	CBL_PTK	1864:1872	Mutation rewiring degron network	0.2778
p.Y1876C	DO228947	LICA	ICGC	NYGYYSRYP	CBL_PTK	1864:1872	Mutation rewiring degron network	0.2222
p.A817S	DO228974	LICA	ICGC	DYR	CBL_MET	807:809	Mutation rewiring degron network	0.1111
p.C1875F	DO229029	LICA	ICGC	NYGYYSRYP	CBL_PTK	1864:1872	Mutation rewiring degron network	0.25
p.E810Q	DO26520	LUSC	ICGC	DYR	CBL_MET	807:809	Mutation rewiring degron network	0.3056
p.P1863L	DO222562	MELA	ICGC	NYGYYSRYP	CBL_PTK	1864:1872	Mutation rewiring degron network	0.3056
p.N1740T	DO28681	OV	ICGC	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation rewiring degron network	0.0556
p.A1746V	DO232224	PBCA	ICGC	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation rewiring degron network	0.2222
p.E811D	DO47442	SKCM	ICGC	DYR	CBL_MET	807:809	Mutation rewiring degron network	0.2778
p.R1756Q	DO43899	UCEC	ICGC	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation rewiring degron network	0.2778
p.N1764S	SIDM00373	Endometrial Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation rewiring degron network	0.0556
p.P1857T	SIDM00318	Kidney Carcinoma	GDSC	NYGYYSRYP	CBL_PTK	1864:1872	Mutation rewiring degron network	0.1389
p.P1857T	VMRC-RCW	kidney	COSMIC	NYGYYSRYP	CBL_PTK	1864:1872	Mutation rewiring degron network	0.1389
p.E1873K	SIDM00945	Colorectal Carcinoma	GDSC	NYGYYSRYP	CBL_PTK	1864:1872	Mutation rewiring degron network	0.3056
p.E1873K	CL-34	large intestine	COSMIC	NYGYYSRYP	CBL_PTK	1864:1872	Mutation rewiring degron network	0.3056
p.N1764K	SIDM01088	Endometrial Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation rewiring degron network	0.0556
p.N1764K	RL95-2	endometrium	COSMIC	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation rewiring degron network	0.0556
p.R1756P	ACH-000786	Lymphoma	CCLE	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation rewiring degron network	0.2778
p.R1756P	Daudi	haematopoietic and lymphoid tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation rewiring degron network	0.2778
p.N1744S	ACH-000974	Endometrial/Uterine Cancer	CCLE	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation rewiring degron network	0.1667
p.D1877N	ACH-002222	Leukemia	CCLE	NYGYYSRYP	CBL_PTK	1864:1872	Mutation rewiring degron network	0.1944
p.D1877N	CTV-1	haematopoietic and lymphoid tissue	COSMIC	NYGYYSRYP	CBL_PTK	1864:1872	Mutation rewiring degron network	0.1944
p.V1756G	DND-41	haematopoietic and lymphoid tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation rewiring degron network	0.2778
p.V1756G	Daudi	haematopoietic and lymphoid tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation rewiring degron network	0.2778
p.V1756G	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation rewiring degron network	0.2778
p.V1750A	DND-41	haematopoietic and lymphoid tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation altering degron motif	0.5825
p.V1750A	Daudi	haematopoietic and lymphoid tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation altering degron motif	0.5825
p.V1750A	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation altering degron motif	0.5825
p.N1753K	RL95-2	endometrium	COSMIC	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation altering degron motif	0.6918
p.V1745G	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation rewiring degron network	0.1944
p.V1745G	DND-41	haematopoietic and lymphoid tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation rewiring degron network	0.1944
p.V1745G	Daudi	haematopoietic and lymphoid tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation rewiring degron network	0.1944
p.N1744K	RL95-2	endometrium	COSMIC	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation rewiring degron network	0.1667
p.V1759A	Daudi	haematopoietic and lymphoid tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation rewiring degron network	0.1944
p.V1759A	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation rewiring degron network	0.1944
p.V1759A	DND-41	haematopoietic and lymphoid tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	1750:1754	Mutation rewiring degron network	0.1944
p.D1862H	LNCaP-Clone-FGC	prostate	COSMIC	NYGYYSRYP	CBL_PTK	1864:1872	Mutation rewiring degron network	0.2778
p.I805T	HC-1	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	807:809	Mutation rewiring degron network	0.2778
p.E1862K	CL-34	large intestine	COSMIC	NYGYYSRYP	CBL_PTK	1864:1872	Mutation rewiring degron network	0.2778
p.E1862Q	COLO-800	skin	COSMIC	NYGYYSRYP	CBL_PTK	1864:1872	Mutation rewiring degron network	0.2778
p.R1867Q	NCI-H1975	lung	COSMIC	NYGYYSRYP	CBL_PTK	1864:1872	Mutation altering degron motif	0.7329
p.D1877H	LNCaP-Clone-FGC	prostate	COSMIC	NYGYYSRYP	CBL_PTK	1864:1872	Mutation rewiring degron network	0.1944
p.R1858Q	NCI-H1975	lung	COSMIC	NYGYYSRYP	CBL_PTK	1864:1872	Mutation rewiring degron network	0.1667
p.R1882Q	NCI-H1975	lung	COSMIC	NYGYYSRYP	CBL_PTK	1864:1872	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CACNA1D

UniProt ID: Q01668

Entrez ID: 776

Protein name: Voltage-dependent L-type calcium channel subunit alpha-1D (Calcium channel, L type, alpha-1 polypeptide, isoform 2) (Voltage-gated calcium channel subunit alpha Cav1.3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CACNA1D in