DegronMD

Uniprot ID: Q01668

Source protein: Voltage-dependent L-type calcium channel subunit alpha-1D

Source gene: CACNA1D

Class: CBL_PTK

Location: 1864:1872

E3 ligase: CBL

DEGRON score: 0.8996

ASA_SCORE: 90.6222

COIL: 0.8988

CONS_SCORE: 0.1344

DSS_SCORE: 0.4115

HELIX: 0.0556

FCONS_SCORE: 0.6999

RIG_SCORE: 0.7299

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1882S	TCGA-AJ-A2QK	UCEC	TCGA	NYGYYSRYP	CBL_PTK	0.0556
p.R1882S	DO41301	UCEC	ICGC	NYGYYSRYP	CBL_PTK	0.0556
p.L1860S	TCGA-BS-A0UF	UCEC	TCGA	NYGYYSRYP	CBL_PTK	0.2222
p.L1860S	DO41488	UCEC	ICGC	NYGYYSRYP	CBL_PTK	0.2222
p.S1868G	TCGA-DK-A1AA	BLCA	TCGA	NYGYYSRYP	CBL_PTK	0.6993
p.E1873Q	TCGA-DU-8158	LGG	TCGA	NYGYYSRYP	CBL_PTK	0.3056
p.E1873Q	DO22413	LGG	ICGC	NYGYYSRYP	CBL_PTK	0.3056
p.E1873Q	SIDM00515	Melanoma	GDSC	NYGYYSRYP	CBL_PTK	0.3056
p.E1873Q	COLO-800	skin	COSMIC	NYGYYSRYP	CBL_PTK	0.3056
p.S1877L	TCGA-ER-A42L	SKCM	TCGA	NYGYYSRYP	CBL_PTK	0.1944
p.S1877L	DO223910	SKCM	ICGC	NYGYYSRYP	CBL_PTK	0.1944
p.P1878T	TCGA-FI-A2F4	UCEC	TCGA	NYGYYSRYP	CBL_PTK	0.1667
p.P1878T	DO43434	UCEC	ICGC	NYGYYSRYP	CBL_PTK	0.1667
p.Q1864K	DO234462	ESAD	ICGC	NYGYYSRYP	CBL_PTK	0.6944
p.Q1864K	DO47374	SKCM	ICGC	NYGYYSRYP	CBL_PTK	0.6944
p.V1874I	DO22237	LGG	ICGC	NYGYYSRYP	CBL_PTK	0.2778
p.Y1876C	DO228947	LICA	ICGC	NYGYYSRYP	CBL_PTK	0.2222
p.C1875F	DO229029	LICA	ICGC	NYGYYSRYP	CBL_PTK	0.25
p.P1863L	DO222562	MELA	ICGC	NYGYYSRYP	CBL_PTK	0.3056
p.P1857T	SIDM00318	Kidney Carcinoma	GDSC	NYGYYSRYP	CBL_PTK	0.1389
p.P1857T	VMRC-RCW	kidney	COSMIC	NYGYYSRYP	CBL_PTK	0.1389
p.E1873K	SIDM00945	Colorectal Carcinoma	GDSC	NYGYYSRYP	CBL_PTK	0.3056
p.E1873K	CL-34	large_intestine	COSMIC	NYGYYSRYP	CBL_PTK	0.3056
p.D1877N	ACH-002222	Leukemia	CCLE	NYGYYSRYP	CBL_PTK	0.1944
p.D1877N	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	NYGYYSRYP	CBL_PTK	0.1944
p.D1862H	LNCaP-Clone-FGC	prostate	COSMIC	NYGYYSRYP	CBL_PTK	0.2778
p.E1862K	CL-34	large_intestine	COSMIC	NYGYYSRYP	CBL_PTK	0.2778
p.E1862Q	COLO-800	skin	COSMIC	NYGYYSRYP	CBL_PTK	0.2778
p.R1867Q	NCI-H1975	lung	COSMIC	NYGYYSRYP	CBL_PTK	0.7329
p.D1877H	LNCaP-Clone-FGC	prostate	COSMIC	NYGYYSRYP	CBL_PTK	0.1944
p.R1858Q	NCI-H1975	lung	COSMIC	NYGYYSRYP	CBL_PTK	0.1667
p.R1882Q	NCI-H1975	lung	COSMIC	NYGYYSRYP	CBL_PTK	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NYGYYSRYP

Degron related mutations and impact score

Drug responses associated with CACNA1D mutations

All proteins holding degron of NYGYYSRYP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	CBL_PTK	1864:1872	NYGYYSRYP	CBL	0.8996	More...