DegronMD - P41587(VIPR2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S398F	TCGA-AR-A2LO	BRCA	TCGA	PTPSAS	DEG_SCF_FBW7_1	395:400	Mutation altering degron motif	0.6871
p.F410L	TCGA-EY-A1GI	UCEC	TCGA	PTPSAS	DEG_SCF_FBW7_1	395:400	Mutation rewiring degron network	0.0556
p.F410L	TCGA-EY-A1GI	UCEC	TCGA	DYR	CBL_MET	402:404	Mutation rewiring degron network	0.1667
p.R393L	TCGA-KL-8345	KICH	TCGA	PTPSAS	DEG_SCF_FBW7_1	395:400	Mutation rewiring degron network	0.2778
p.R393L	TCGA-KL-8345	KICH	TCGA	DYR	CBL_MET	402:404	Mutation rewiring degron network	0.0833
p.L386Q	TCGA-UB-A7MB	LIHC	TCGA	PTPSAS	DEG_SCF_FBW7_1	395:400	Mutation rewiring degron network	0.0833
p.Q404L	DO219563	LIHC	ICGC	DYR	CBL_MET	402:404	Mutation altering degron motif	0.7765
p.A402S	DO229259	THCA	ICGC	DYR	CBL_MET	402:404	Mutation altering degron motif	0.7588
p.A411D	DO229213	THCA	ICGC	DYR	CBL_MET	402:404	Mutation rewiring degron network	0.1389
p.F394L	DO41211	UCEC	ICGC	PTPSAS	DEG_SCF_FBW7_1	395:400	Mutation rewiring degron network	0.3056
p.F394L	DO41211	UCEC	ICGC	DYR	CBL_MET	402:404	Mutation rewiring degron network	0.1111
p.W390C	SIDM00216	Colorectal Carcinoma	GDSC	PTPSAS	DEG_SCF_FBW7_1	395:400	Mutation rewiring degron network	0.1944
p.W390C	ACH-000989	Colon/Colorectal Cancer	CCLE	PTPSAS	DEG_SCF_FBW7_1	395:400	Mutation rewiring degron network	0.1944
p.R412H	ACH-000953	Leukemia	CCLE	DYR	CBL_MET	402:404	Mutation rewiring degron network	0.1111
p.T396P	ACH-000988	Endometrial/Uterine Cancer	CCLE	PTPSAS	DEG_SCF_FBW7_1	395:400	Mutation altering degron motif	0.7031
p.T396P	ACH-001364	Lung Cancer	CCLE	PTPSAS	DEG_SCF_FBW7_1	395:400	Mutation altering degron motif	0.7031
p.T396P	ACH-002271	Sarcoma	CCLE	PTPSAS	DEG_SCF_FBW7_1	395:400	Mutation altering degron motif	0.7031
p.V395I	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	PTPSAS	DEG_SCF_FBW7_1	395:400	Mutation altering degron motif	0.7076
p.L405F	NCI-H1666	lung	COSMIC	PTPSAS	DEG_SCF_FBW7_1	395:400	Mutation rewiring degron network	0.1944
p.L405F	NCI-H1666	lung	COSMIC	DYR	CBL_MET	402:404	Mutation rewiring degron network	0.3056

Kaplan plot for VIPR2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VIPR2

UniProt ID: P41587

Entrez ID: 7434

Protein name: Vasoactive intestinal polypeptide receptor 2 (VIP-R-2) (Helodermin-preferring VIP receptor) (Pituitary adenylate cyclase-activating polypeptide type III receptor) (PACAP type III receptor) (PACAP-R-3) (PACAP-R3) (VPAC2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VIPR2 in