DegronMD

Uniprot ID: P41587

Source protein: Vasoactive intestinal polypeptide receptor 2

Source gene: VIPR2

Class: DEG_SCF_FBW7_1

Location: 395:400

E3 ligase: FBXW7

DEGRON score: 0.7761

ASA_SCORE: 88.5167

COIL: 0.9125

CONS_SCORE: 0.2698

DSS_SCORE: 0.2395

HELIX: 0.0738

FCONS_SCORE: 0.5601

RIG_SCORE: 0.7138

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S398F	TCGA-AR-A2LO	BRCA	TCGA	PTPSAS	DEG_SCF_FBW7_1	0.6871
p.F410L	TCGA-EY-A1GI	UCEC	TCGA	PTPSAS	DEG_SCF_FBW7_1	0.0556
p.R393L	TCGA-KL-8345	KICH	TCGA	PTPSAS	DEG_SCF_FBW7_1	0.2778
p.L386Q	TCGA-UB-A7MB	LIHC	TCGA	PTPSAS	DEG_SCF_FBW7_1	0.0833
p.F394L	DO41211	UCEC	ICGC	PTPSAS	DEG_SCF_FBW7_1	0.3056
p.W390C	SIDM00216	Colorectal Carcinoma	GDSC	PTPSAS	DEG_SCF_FBW7_1	0.1944
p.W390C	ACH-000989	Colon/Colorectal Cancer	CCLE	PTPSAS	DEG_SCF_FBW7_1	0.1944
p.T396P	ACH-000988	Endometrial/Uterine Cancer	CCLE	PTPSAS	DEG_SCF_FBW7_1	0.7031
p.T396P	ACH-001364	Lung Cancer	CCLE	PTPSAS	DEG_SCF_FBW7_1	0.7031
p.T396P	ACH-002271	Sarcoma	CCLE	PTPSAS	DEG_SCF_FBW7_1	0.7031
p.V395I	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	PTPSAS	DEG_SCF_FBW7_1	0.7076
p.L405F	NCI-H1666	lung	COSMIC	PTPSAS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15516	Circadian locomoter output cycles protein kaput	DEG_SCF_FBW7_1	428:433	PTPSAS	FBXW7	0.9968	More...
P41587	Vasoactive intestinal polypeptide receptor 2	DEG_SCF_FBW7_1	395:400	PTPSAS	FBXW7	0.7761	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons